Homo sapiens Gene: LALBA
Summary
InnateDB Gene IDBG-30143.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LALBA
Gene Name lactalbumin, alpha-
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000167531
Encoded Proteins
lactalbumin, alpha-
lactalbumin, alpha-
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes alpha-lactalbumin, a principal protein of milk. Alpha-lactalbumin forms the regulatory subunit of the lactose synthase (LS) heterodimer and beta 1,4-galactosyltransferase (beta4Gal-T1) forms the catalytic component. Together, these proteins enable LS to produce lactose by transfering galactose moieties to glucose. As a monomer, alpha-lactalbumin strongly binds calcium and zinc ions and may possess bactericidal or antitumor activity. A folding variant of alpha-lactalbumin, called HAMLET, likely induces apoptosis in tumor and immature cells. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:48567684-48570066
Strand Reverse strand
Band q13.11
Transcripts
ENST00000301046 ENSP00000301046
ENST00000549817 ENSP00000449780
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004461 lactose synthase activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
Biological Process
GO:0005989 lactose biosynthetic process
GO:0006915 apoptotic process
GO:0007165 signal transduction
GO:0007267 cell-cell signaling
GO:0042742 defense response to bacterium
Cellular Component
GO:0005615 extracellular space
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
REACTOME
KEGG
Galactose metabolism pathway
INOH
Galactose metabolism pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.72938
RefSeq NM_002289 XM_006719395
HUGO
OMIM
CCDS CCDS8765
HPRD 01024
IMGT
EMBL
GenPept
RNA Seq Atlas