Version 5.4
Mus musculus Gene: Tln2
Summary
InnateDB Gene IDBG-180368.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tln2
Gene Name talin 2
Synonyms 5730421P04Rik; AI507121; AI787438; AL118320; mKIAA0320
Species Mus musculus
Ensembl Gene ENSMUSG00000052698
Encoded Proteins
IDBP-180374
talin 2
IDBP-180378
talin 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000171914:
This gene encodes a protein related to talin 1, a cytoskeletal protein that plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. This protein has a different pattern of expression compared to talin 1 but, like talin 1, is thought to associate with unique transmembrane receptors to form novel linkages between extracellular matrices and the actin cytoskeleton. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:67217087-67559703
Strand Reverse strand
Band C
Transcripts
ENSMUST00000040025 ENSMUSP00000039633
ENSMUST00000039662 ENSMUSP00000035272
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005158 insulin receptor binding
GO:0005198 structural molecule activity
GO:0005200 structural constituent of cytoskeleton
GO:0005515 protein binding
Biological Process
GO:0007016 cytoskeletal anchoring at plasma membrane
GO:0007155 cell adhesion
Cellular Component
GO:0001726 ruffle
GO:0005856 cytoskeleton
GO:0005916 fascia adherens
GO:0005925 focal adhesion
GO:0015629 actin cytoskeleton
GO:0045202 synapse
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000171914
View Gene Order
ENSBTAG00000003667
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04510
Focal adhesion pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04510
Focal adhesion pathway
INOH
INOH website
Integrin signaling pathway pathway
PID NCI
Cross-References
SwissProt
TrEMBL E9PUM4 Q3TN69
UniProt Splice Variant
Entrez Gene 70549
UniGene Mm.33645
RefSeq NM_001081242 XM_006511433 XM_006511435 XM_006511436 XM_006511437 XM_006511438
OMIM
CCDS CCDS52849
HPRD
IMGT
MGI ID MGI:1917799
MGI Symbol Tln2
EMBL AC107740 AC107755 AC173343 AK165499
GenPept BAE38220
RNA Seq Atlas 70549

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca