Homo sapiens Gene: TLN2
Summary
InnateDB Gene IDBG-15260.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TLN2
Gene Name talin 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000171914
Encoded Proteins
talin 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein related to talin 1, a cytoskeletal protein that plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. This protein has a different pattern of expression compared to talin 1 but, like talin 1, is thought to associate with unique transmembrane receptors to form novel linkages between extracellular matrices and the actin cytoskeleton. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:62390526-62844631
Strand Forward strand
Band q22.2
Transcripts
ENST00000306829 ENSP00000303476
ENST00000474847
ENST00000494733 ENSP00000453730
ENST00000489129
ENST00000472902 ENSP00000453812
ENST00000467297
ENST00000561322
ENST00000561197
ENST00000561311 ENSP00000453508
ENST00000559908
ENST00000559174
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
Experimentally validated
Total 14 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005158 insulin receptor binding
GO:0005198 structural molecule activity
GO:0005200 structural constituent of cytoskeleton
GO:0005515 protein binding
GO:0051015 actin filament binding
Biological Process
GO:0007016 cytoskeletal anchoring at plasma membrane
GO:0007043 cell-cell junction assembly
GO:0007155 cell adhesion
Cellular Component
GO:0001726 ruffle
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0005916 fascia adherens
GO:0005925 focal adhesion
GO:0015629 actin cytoskeleton
GO:0045202 synapse
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Focal adhesion pathway
INOH
Integrin signaling pathway pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q9Y4G6
TrEMBL
UniProt Splice Variant
Entrez Gene 83660
UniGene Hs.569438 Hs.595656 Hs.731758
RefSeq XM_006720718 NM_015059 XM_006720720
HUGO HGNC:15447
OMIM 607349
CCDS CCDS32261
HPRD 09555
IMGT
EMBL AB002318 AC068233 AC100839 AC103740 AF402000
GenPept AAM73764 BAA20778
RNA Seq Atlas 83660