Version 5.4
Homo sapiens Gene: TLN2
Summary
InnateDB Gene IDBG-15260.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TLN2
Gene Name talin 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000171914
Encoded Proteins
IDBP-15262
talin 2
IDBP-595686
talin 2
IDBP-598700
talin 2
IDBP-585902
talin 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein related to talin 1, a cytoskeletal protein that plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. This protein has a different pattern of expression compared to talin 1 but, like talin 1, is thought to associate with unique transmembrane receptors to form novel linkages between extracellular matrices and the actin cytoskeleton. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:62390526-62844631
Strand Forward strand
Band q22.2
Transcripts
ENST00000306829 ENSP00000303476
ENST00000474847
ENST00000494733 ENSP00000453730
ENST00000489129
ENST00000472902 ENSP00000453812
ENST00000467297
ENST00000561322
ENST00000561197
ENST00000561311 ENSP00000453508
ENST00000559908
ENST00000559174
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
Experimentally validated
Total 14 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005158 insulin receptor binding
GO:0005198 structural molecule activity
GO:0005200 structural constituent of cytoskeleton
GO:0005515 protein binding
GO:0051015 actin filament binding
Biological Process
GO:0007016 cytoskeletal anchoring at plasma membrane
GO:0007043 cell-cell junction assembly
GO:0007155 cell adhesion
Cellular Component
GO:0001726 ruffle
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0005916 fascia adherens
GO:0005925 focal adhesion
GO:0015629 actin cytoskeleton
GO:0045202 synapse
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000052698
View Gene Order
ENSBTAG00000003667
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04510
Focal adhesion pathway
INOH
INOH website
Integrin signaling pathway pathway
PID NCI
Cross-References
SwissProt
TrEMBL H0YN01
UniProt Splice Variant
Entrez Gene 83660
UniGene Hs.569438 Hs.595656 Hs.731758
RefSeq NM_015059 XM_006720718 XM_006720720
HUGO HGNC:15447
OMIM 607349
CCDS CCDS32261
HPRD 09555
IMGT
EMBL AC011927 AC032011 AC068233 AC100839 AC103740
GenPept
RNA Seq Atlas 83660

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca