Mus musculus Gene: Ccnt1
Summary
InnateDB Gene IDBG-180494.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ccnt1
Gene Name cyclin T1
Synonyms 2810478G24Rik; AI115585; CycT1;
Species Mus musculus
Ensembl Gene ENSMUSG00000011960
Encoded Proteins
cyclin T1
cyclin T1
cyclin T1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
[Homo sapiens] Heterodimerizes with CDK9 to form the positive transcriptional elongation factor b (P-TEFb) and plays a role in the activation of a subset of NF-kappaB dependent targets
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000129315:
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin tightly associates with CDK9 kinase, and was found to be a major subunit of the transcription elongation factor p-TEFb. The kinase complex containing this cyclin and the elongation factor can interact with, and act as a cofactor of human immunodeficiency virus type 1 (HIV-1) Tat protein, and was shown to be both necessary and sufficient for full activation of viral transcription. This cyclin and its kinase partner were also found to be involved in the phosphorylation and regulation of the carboxy-terminal domain (CTD) of the largest RNA polymerase II subunit. [provided by RefSeq, Jul 2008]
This gene encodes a member of the highly conserved cyclin C subfamily. The encoded protein tightly associates with cyclin-dependent kinase 9, and is a major subunit of positive transcription elongation factor b (p-TEFb). In humans, there are multiple forms of positive transcription elongation factor b, which may include one of several different cyclins along with cyclin-dependent kinase 9. The complex containing the encoded cyclin and cyclin-dependent kinase 9 acts as a cofactor of human immunodeficiency virus type 1 (HIV-1) Tat protein, and is both necessary and sufficient for full activation of viral transcription. This cyclin and its kinase partner are also involved in triggering transcript elongation through phosphorylation of the carboxy-terminal domain of the largest RNA polymerase II subunit. Overexpression of this gene is implicated in tumor growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:98538689-98570923
Strand Reverse strand
Band F1
Transcripts
ENSMUST00000012104 ENSMUSP00000012104
ENSMUST00000130921
ENSMUST00000169707 ENSMUSP00000126874
ENSMUST00000163180
ENSMUST00000168928 ENSMUSP00000130286
ENSMUST00000170452
ENSMUST00000169674
ENSMUST00000164294
ENSMUST00000164565
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 71 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 2 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 71 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0005515 protein binding
GO:0017069 snRNA binding
GO:0019901 protein kinase binding
GO:0044212 transcription regulatory region DNA binding
Biological Process
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006468 protein phosphorylation
GO:0007049 cell cycle
GO:0051301 cell division
Cellular Component
GO:0005634 nucleus
GO:0008024 positive transcription elongation factor complex b
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
Disease pathway
Loss of Function of SMAD4 in Cancer pathway
Signaling by TGF-beta Receptor Complex in Cancer pathway
TGFBR1 LBD Mutants in Cancer pathway
Formation of RNA Pol II elongation complex pathway
Loss of Function of TGFBR2 in Cancer pathway
SMAD2/3 MH2 Domain Mutants in Cancer pathway
RNA Polymerase II Transcription Elongation pathway
TGFBR2 Kinase Domain Mutants in Cancer pathway
RNA Polymerase II Pre-transcription Events pathway
Gene Expression pathway
Loss of Function of TGFBR1 in Cancer pathway
TGFBR2 MSI Frameshift Mutants in Cancer pathway
SMAD4 MH2 Domain Mutants in Cancer pathway
Generic Transcription Pathway pathway
Signal Transduction pathway
TGFBR1 KD Mutants in Cancer pathway
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer pathway
RNA Polymerase II Transcription pathway
Signaling by TGF-beta Receptor Complex pathway
Loss of Function of SMAD2/3 in Cancer pathway
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
TNFalpha pathway
REACTOME
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription pathway
SMAD4 MH2 Domain Mutants in Cancer pathway
Loss of Function of SMAD4 in Cancer pathway
Loss of Function of SMAD2/3 in Cancer pathway
Signaling by TGF-beta Receptor Complex in Cancer pathway
Pausing and recovery of Tat-mediated HIV elongation pathway
Late Phase of HIV Life Cycle pathway
TGFBR2 MSI Frameshift Mutants in Cancer pathway
Signal Transduction pathway
Formation of HIV-1 elongation complex containing HIV-1 Tat pathway
Tat-mediated elongation of the HIV-1 transcript pathway
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer pathway
Tat-mediated HIV elongation arrest and recovery pathway
SMAD2/3 MH2 Domain Mutants in Cancer pathway
Loss of Function of TGFBR2 in Cancer pathway
Formation of RNA Pol II elongation complex pathway
HIV Transcription Elongation pathway
Formation of HIV elongation complex in the absence of HIV Tat pathway
Generic Transcription Pathway pathway
RNA Polymerase II Transcription pathway
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
Pausing and recovery of HIV elongation pathway
HIV Life Cycle pathway
HIV elongation arrest and recovery pathway
RNA Polymerase II Pre-transcription Events pathway
Transcription of the HIV genome pathway
TGFBR1 KD Mutants in Cancer pathway
RNA Polymerase II Transcription Elongation pathway
HIV Infection pathway
Loss of Function of TGFBR1 in Cancer pathway
TGFBR1 LBD Mutants in Cancer pathway
TGFBR2 Kinase Domain Mutants in Cancer pathway
Host Interactions of HIV factors pathway
Interactions of Tat with host cellular proteins pathway
Gene Expression pathway
Disease pathway
Signaling by TGF-beta Receptor Complex pathway
Generic Transcription Pathway pathway
RNA Polymerase II Transcription pathway
Loss of Function of TGFBR1 in Cancer pathway
Signaling by TGF-beta Receptor Complex pathway
SMAD2/3 MH2 Domain Mutants in Cancer pathway
RNA Polymerase II Pre-transcription Events pathway
Loss of Function of SMAD4 in Cancer pathway
Loss of Function of TGFBR2 in Cancer pathway
Gene Expression pathway
TGFBR2 Kinase Domain Mutants in Cancer pathway
Signal Transduction pathway
RNA Polymerase II Transcription Elongation pathway
Signaling by TGF-beta Receptor Complex in Cancer pathway
Formation of RNA Pol II elongation complex pathway
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer pathway
SMAD4 MH2 Domain Mutants in Cancer pathway
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription pathway
TGFBR2 MSI Frameshift Mutants in Cancer pathway
Loss of Function of SMAD2/3 in Cancer pathway
TGFBR1 LBD Mutants in Cancer pathway
Disease pathway
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
TGFBR1 KD Mutants in Cancer pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.29941 Mm.488259 Mm.488962 Mm.86538
RefSeq NM_009833
OMIM
CCDS CCDS27797
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas