Version 5.4
Mus musculus Gene: Amfr
Summary
InnateDB Gene IDBG-181239.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Amfr
Gene Name autocrine motility factor receptor
Synonyms gp78
Species Mus musculus
Ensembl Gene ENSMUSG00000031751
Encoded Proteins
IDBP-181241
autocrine motility factor receptor
IDBP-717034
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 25526307
[Homo sapiens] Upon cytoplasmic DNA stimulation, the endoplasmic reticulum protein AMFR is recruited to and interacts with TMEM173 in an INSIG1-dependent manner.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000159461:
This locus encodes a glycosylated transmembrane receptor. Its ligand, autocrine motility factor, is a tumor motility-stimulating protein secreted by tumor cells. The encoded receptor is also a member of the E3 ubiquitin ligase family of proteins. It catalyzes ubiquitination and endoplasmic reticulum-associated degradation of specific proteins. [provided by RefSeq, Feb 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:93971588-94012663
Strand Reverse strand
Band C5
Transcripts
ENSMUST00000053766 ENSMUSP00000052258
ENSMUST00000139702
ENSMUST00000137475
ENSMUST00000143265 ENSMUSP00000134924
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 77 interaction(s) predicted by orthology.
Experimentally validated
Total 13 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 77 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0004842 ubiquitin-protein transferase activity
GO:0004872 receptor activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0046872 metal ion binding
Biological Process
GO:0000209 protein polyubiquitination
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0007568 aging
GO:0007611 learning or memory
GO:0009987 cellular process
GO:0030433 ER-associated ubiquitin-dependent protein catabolic process
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0051259 protein oligomerization
Cellular Component
GO:0000836 Hrd1p ubiquitin ligase complex
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005789 endoplasmic reticulum membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0030176 integral component of endoplasmic reticulum membrane
GO:0030425 dendrite
GO:0030426 growth cone
GO:0043025 neuronal cell body
GO:0043234 protein complex
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000159461
View Gene Order
ENSBTAG00000003798
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL H3BJC0
UniProt Splice Variant
Entrez Gene 23802
UniGene Mm.34641 Mm.399630
RefSeq NM_011787
OMIM
CCDS CCDS22533
HPRD
IMGT
MGI ID MGI:1345634
MGI Symbol Amfr
EMBL AC138118
GenPept
RNA Seq Atlas 23802

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca