Version 5.4
Mus musculus Gene: Wnt1
Summary
InnateDB Gene IDBG-181251.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Wnt1
Gene Name wingless-related MMTV integration site 1
Synonyms Int-1; sw; swaying; Wnt-1
Species Mus musculus
Ensembl Gene ENSMUSG00000022997
Encoded Proteins
IDBP-181253
wingless-related MMTV integration site 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000125084:
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is very conserved in evolution, and the protein encoded by this gene is known to be 98% identical to the mouse Wnt1 protein at the amino acid level. The studies in mouse indicate that the Wnt1 protein functions in the induction of the mesencephalon and cerebellum. This gene was originally considered as a candidate gene for Joubert syndrome, an autosomal recessive disorder with cerebellar hypoplasia as a leading feature. However, further studies suggested that the gene mutations might not have a significant role in Joubert syndrome. This gene is clustered with another family member, WNT10B, in the chromosome 12q13 region. [provided by RefSeq, Jul 2008]
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is very conserved in evolution, and the protein encoded by this gene is known to be 98%% identical to the mouse Wnt1 protein at the amino acid level. The studies in mouse indicate that the Wnt1 protein functions in the induction of the mesencephalon and cerebellum. This gene was originally considered as a candidate gene for Joubert syndrome, an autosomal recessive disorder with cerebellar hypoplasia as a leading feature. However, further studies suggested that the gene mutations might not have a significant role in Joubert syndrome. This gene is clustered with another family member, WNT10B, in the chromosome 12q13 region. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:98789857-98793837
Strand Forward strand
Band F1
Transcripts
ENSMUST00000023734 ENSMUSP00000023734
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 17 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 6 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005109 frizzled binding
GO:0005125 cytokine activity
GO:0005515 protein binding
GO:0019904 protein domain specific binding
GO:0044212 transcription regulatory region DNA binding
Biological Process
GO:0000578 embryonic axis specification
GO:0001658 branching involved in ureteric bud morphogenesis
GO:0001934 positive regulation of protein phosphorylation
GO:0007165 signal transduction
GO:0007267 cell-cell signaling
GO:0007275 multicellular organismal development
GO:0007520 myoblast fusion
GO:0008284 positive regulation of cell proliferation
GO:0009611 response to wounding
GO:0009887 organ morphogenesis
GO:0010592 positive regulation of lamellipodium assembly
GO:0010812 negative regulation of cell-substrate adhesion
GO:0014902 myotube differentiation
GO:0016055 Wnt signaling pathway
GO:0021527 spinal cord association neuron differentiation
GO:0021536 diencephalon development
GO:0021551 central nervous system morphogenesis
GO:0021588 cerebellum formation
GO:0021797 forebrain anterior/posterior pattern specification
GO:0022004 midbrain-hindbrain boundary maturation during brain development
GO:0022037 metencephalon development
GO:0022408 negative regulation of cell-cell adhesion
GO:0030509 BMP signaling pathway
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030514 negative regulation of BMP signaling pathway
GO:0030579 ubiquitin-dependent SMAD protein catabolic process
GO:0030901 midbrain development
GO:0030917 midbrain-hindbrain boundary development
GO:0031100 organ regeneration
GO:0033077 T cell differentiation in thymus
GO:0042472 inner ear morphogenesis
GO:0042770 signal transduction in response to DNA damage
GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway
GO:0044336 canonical Wnt signaling pathway involved in negative regulation of apoptotic process
GO:0045596 negative regulation of cell differentiation
GO:0045599 negative regulation of fat cell differentiation
GO:0045747 positive regulation of Notch signaling pathway
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048146 positive regulation of fibroblast proliferation
GO:0048663 neuron fate commitment
GO:0048664 neuron fate determination
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0060061 Spemann organizer formation
GO:0060070 canonical Wnt signaling pathway
GO:0060348 bone development
GO:0061184 positive regulation of dermatome development
GO:0070365 hepatocyte differentiation
GO:0071375 cellular response to peptide hormone stimulus
GO:0071425 hematopoietic stem cell proliferation
GO:0090344 negative regulation of cell aging
GO:2000059 negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
Cellular Component
GO:0005576 extracellular region
GO:0005578 proteinaceous extracellular matrix
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005788 endoplasmic reticulum lumen
GO:0009986 cell surface
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000125084
View Gene Order
ENSBTAG00000015364
Not yet available
Pathways
NETPATH
REACTOME
REACT_27166
Transcriptional Regulation of Adipocyte Differentiation in 3T3-L1 Pre-adipocytes pathway
REACT_252217
Transcriptional regulation of white adipocyte differentiation pathway
REACT_200794
Mus musculus biological processes pathway
REACT_189085
Disease pathway
REACT_214014
Signaling by Wnt pathway
REACT_254215
Signaling by GPCR pathway
REACT_250061
Class B/2 (Secretin family receptors) pathway
REACT_213918
WNT ligand biogenesis and trafficking pathway
REACT_233046
Signaling by WNT in cancer pathway
REACT_226355
beta-catenin independent WNT signaling pathway
REACT_262115
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
REACT_214043
PCP/CE pathway pathway
REACT_241644
RNF mutants show enhanced WNT signaling and proliferation pathway
REACT_216784
disassembly of the destruction complex and recruitment of AXIN to the membrane pathway
REACT_207044
TCF dependent signaling in response to WNT pathway
REACT_231468
GPCR ligand binding pathway
REACT_246422
WNT ligand secretion is abrogated by the PORCN inhibitor LGK974 pathway
REACT_188576
Developmental Biology pathway
REACT_188257
Signal Transduction pathway
REACT_241402
XAV939 inhibits tankyrase, stabilizing AXIN pathway
KEGG
mmu05217
Basal cell carcinoma pathway
mmu04916
Melanogenesis pathway
mmu04310
Wnt signaling pathway pathway
mmu04340
Hedgehog signaling pathway pathway
mmu05200
Pathways in cancer pathway
INOH
INOH website
Wnt signaling pathway pathway
INOH website
GPCR signaling pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_8
Wnt pathway
REACTOME
REACT_18372
Class B/2 (Secretin family receptors) pathway
REACT_27161
Transcriptional regulation of white adipocyte differentiation pathway
REACT_172581
PCP/CE pathway pathway
REACT_111045
Developmental Biology pathway
REACT_228096
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
REACT_228331
Signaling by WNT in cancer pathway
REACT_172694
beta-catenin independent WNT signaling pathway
REACT_11045
Signaling by Wnt pathway
REACT_14797
Signaling by GPCR pathway
REACT_200610
disassembly of the destruction complex and recruitment of AXIN to the membrane pathway
REACT_228014
WNT ligand secretion is abrogated by the PORCN inhibitor LGK974 pathway
REACT_111102
Signal Transduction pathway
REACT_163710
WNT ligand biogenesis and trafficking pathway
REACT_200777
TCF dependent signaling in response to WNT pathway
REACT_228188
RNF mutants show enhanced WNT signaling and proliferation pathway
REACT_21340
GPCR ligand binding pathway
REACT_228279
XAV939 inhibits tankyrase, stabilizing AXIN pathway
REACT_116125
Disease pathway
KEGG
hsa04310
Wnt signaling pathway pathway
hsa04340
Hedgehog signaling pathway pathway
hsa05217
Basal cell carcinoma pathway
hsa04916
Melanogenesis pathway
hsa05200
Pathways in cancer pathway
INOH
INOH website
Wnt signaling pathway pathway
INOH website
GPCR signaling pathway
PID NCI
ps1pathway
Presenilin action in Notch and Wnt signaling
wnt_signaling_pathway
Wnt signaling network
cmyb_pathway
C-MYB transcription factor network
Cross-References
SwissProt P04426
TrEMBL Q3UR96 Q91V65
UniProt Splice Variant
Entrez Gene 22408
UniGene Mm.1123
RefSeq NM_021279 XM_006520890
OMIM
CCDS CCDS27807
HPRD
IMGT
MGI ID MGI:98953
MGI Symbol Wnt1
EMBL AB039234 AB039235 AB039236 AB039237 AB039238 AB039239 AB039240 AB039241 AB039242 AK141669 BC005449 CH466550 K02593 M11943
GenPept AAA39321 AAA39322 AAH05449 BAB68758 BAB68759 BAB68760 BAB68761 BAB68762 BAB68763 BAB68764 BAB68765 BAB68766 BAE24792 EDL04166
RNA Seq Atlas 22408

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca