InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: WNT1

Summary

InnateDB Gene

IDBG-30719.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

WNT1

Gene Name

wingless-type MMTV integration site family, member 1

Synonyms

BMND16; INT1; OI15

Species

Homo sapiens

Ensembl Gene

ENSG00000125084

Encoded Proteins

IDBP-30721

wingless-type MMTV integration site family, member 1

IDBP-808559

wingless-type MMTV integration site family, member 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is very conserved in evolution, and the protein encoded by this gene is known to be 98% identical to the mouse Wnt1 protein at the amino acid level. The studies in mouse indicate that the Wnt1 protein functions in the induction of the mesencephalon and cerebellum. This gene was originally considered as a candidate gene for Joubert syndrome, an autosomal recessive disorder with cerebellar hypoplasia as a leading feature. However, further studies suggested that the gene mutations might not have a significant role in Joubert syndrome. This gene is clustered with another family member, WNT10B, in the chromosome 12q13 region. [provided by RefSeq, Jul 2008]
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is very conserved in evolution, and the protein encoded by this gene is known to be 98%% identical to the mouse Wnt1 protein at the amino acid level. The studies in mouse indicate that the Wnt1 protein functions in the induction of the mesencephalon and cerebellum. This gene was originally considered as a candidate gene for Joubert syndrome, an autosomal recessive disorder with cerebellar hypoplasia as a leading feature. However, further studies suggested that the gene mutations might not have a significant role in Joubert syndrome. This gene is clustered with another family member, WNT10B, in the chromosome 12q13 region. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:48978453-48981676

Strand

Forward strand

Band

q13.12

Transcripts

ENST00000293549	ENSP00000293549
ENST00000613114	ENSP00000481240

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	8 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005109	frizzled binding
GO:0005125	cytokine activity
GO:0005515	protein binding
GO:0019904	protein domain specific binding
GO:0044212	transcription regulatory region DNA binding
GO:0048018	receptor agonist activity

Biological Process

GO:0000578	embryonic axis specification
GO:0001658	branching involved in ureteric bud morphogenesis
GO:0001934	positive regulation of protein phosphorylation
GO:0007267	cell-cell signaling
GO:0007275	multicellular organismal development
GO:0007520	myoblast fusion
GO:0008284	positive regulation of cell proliferation
GO:0009611	response to wounding
GO:0010592	positive regulation of lamellipodium assembly
GO:0010812	negative regulation of cell-substrate adhesion
GO:0014902	myotube differentiation
GO:0016055	Wnt signaling pathway
GO:0021527	spinal cord association neuron differentiation
GO:0021536	diencephalon development
GO:0021551	central nervous system morphogenesis
GO:0021588	cerebellum formation
GO:0021797	forebrain anterior/posterior pattern specification
GO:0022004	midbrain-hindbrain boundary maturation during brain development
GO:0022037	metencephalon development
GO:0022408	negative regulation of cell-cell adhesion
GO:0030182	neuron differentiation
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030514	negative regulation of BMP signaling pathway
GO:0030579	ubiquitin-dependent SMAD protein catabolic process
GO:0030901	midbrain development
GO:0030917	midbrain-hindbrain boundary development
GO:0031100	organ regeneration
GO:0033077	T cell differentiation in thymus
GO:0042472	inner ear morphogenesis
GO:0042770	signal transduction in response to DNA damage
GO:0043568	positive regulation of insulin-like growth factor receptor signaling pathway
GO:0044336	canonical Wnt signaling pathway involved in negative regulation of apoptotic process
GO:0045165	cell fate commitment
GO:0045596	negative regulation of cell differentiation
GO:0045599	negative regulation of fat cell differentiation
GO:0045747	positive regulation of Notch signaling pathway
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048146	positive regulation of fibroblast proliferation
GO:0048663	neuron fate commitment
GO:0048664	neuron fate determination
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0060061	Spemann organizer formation
GO:0060070	canonical Wnt signaling pathway
GO:0060348	bone development
GO:0061184	positive regulation of dermatome development
GO:0070365	hepatocyte differentiation
GO:0071375	cellular response to peptide hormone stimulus
GO:0071425	hematopoietic stem cell proliferation
GO:0090344	negative regulation of cell aging
GO:2000059	negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005788	endoplasmic reticulum lumen
GO:0005796	Golgi lumen
GO:0005886	plasma membrane
GO:0009986	cell surface