Version 5.4
Mus musculus Gene: Anxa3
Summary
InnateDB Gene IDBG-181899.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Anxa3
Gene Name annexin A3
Synonyms Anx3
Species Mus musculus
Ensembl Gene ENSMUSG00000029484
Encoded Proteins
IDBP-181901
annexin A3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000138772:
This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions in the inhibition of phopholipase A2 and cleavage of inositol 1,2-cyclic phosphate to form inositol 1-phosphate. This protein may also play a role in anti-coagulation. [provided by RefSeq, Jul 2008]
This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions in the inhibition of phopholipase A2 and cleavage of inositol 1,2-cyclic phosphate to form inositol 1-phosphate. This protein may also play a role in anti-coagulation. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:96793385-96845968
Strand Forward strand
Band E3
Transcripts
ENSMUST00000031447 ENSMUSP00000031447
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005544 calcium-dependent phospholipid binding
GO:0019834 phospholipase A2 inhibitor activity
GO:0048306 calcium-dependent protein binding
Biological Process
GO:0006909 phagocytosis
GO:0010595 positive regulation of endothelial cell migration
GO:0042742 defense response to bacterium
GO:0043086 negative regulation of catalytic activity
GO:0043312 neutrophil degranulation
GO:0045766 positive regulation of angiogenesis
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0030670 phagocytic vesicle membrane
GO:0042581 specific granule
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000138772
View Gene Order
ENSBTAG00000010153
Not yet available
Cross-References
SwissProt O35639
TrEMBL
UniProt Splice Variant
Entrez Gene 11745
UniGene
RefSeq NM_013470 XM_006534734
OMIM
CCDS CCDS51568
HPRD
IMGT
MGI ID MGI:1201378
MGI Symbol Anxa3
EMBL AJ001633 AK150922 AK150951 AK151771 AK152863 AK168396 AK168507 BC090634
GenPept AAH90634 BAE29960 BAE29984 BAE30677 BAE31554 BAE40320 BAE40390 CAA04887
RNA Seq Atlas 11745

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca