Version 5.4
Homo sapiens Gene: ANXA3
Summary
InnateDB Gene IDBG-26122.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ANXA3
Gene Name annexin A3
Synonyms ANX3
Species Homo sapiens
Ensembl Gene ENSG00000138772
Encoded Proteins
IDBP-26124
annexin A3
IDBP-481693
annexin A3
IDBP-481756
annexin A3
IDBP-484422
annexin A3
IDBP-476826
annexin A3
IDBP-482521
annexin A3
IDBP-478066
annexin A3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions in the inhibition of phopholipase A2 and cleavage of inositol 1,2-cyclic phosphate to form inositol 1-phosphate. This protein may also play a role in anti-coagulation. [provided by RefSeq, Jul 2008]
This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions in the inhibition of phopholipase A2 and cleavage of inositol 1,2-cyclic phosphate to form inositol 1-phosphate. This protein may also play a role in anti-coagulation. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:78551519-78610451
Strand Forward strand
Band q21.21
Transcripts
ENST00000264908 ENSP00000264908
ENST00000512884 ENSP00000423068
ENST00000512542 ENSP00000426591
ENST00000503570 ENSP00000421015
ENST00000510502
ENST00000512373 ENSP00000424584
ENST00000514171 ENSP00000421512
ENST00000508214 ENSP00000422281
ENST00000505805
ENST00000503776
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 14 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004859 phospholipase inhibitor activity
GO:0005509 calcium ion binding
GO:0005544 calcium-dependent phospholipid binding
GO:0019834 phospholipase A2 inhibitor activity
GO:0048306 calcium-dependent protein binding
Biological Process
GO:0006909 phagocytosis
GO:0010595 positive regulation of endothelial cell migration
GO:0042742 defense response to bacterium
GO:0043086 negative regulation of catalytic activity
GO:0043312 neutrophil degranulation
GO:0045766 positive regulation of angiogenesis
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0030670 phagocytic vesicle membrane
GO:0042581 specific granule
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029484
View Gene Order
ENSBTAG00000010153
Not yet available
Cross-References
SwissProt
TrEMBL D6RA82
UniProt Splice Variant
Entrez Gene 306
UniGene Hs.480042
RefSeq NM_005139 XM_005262973
HUGO HGNC:541
OMIM 106490
CCDS CCDS3584
HPRD 00111
IMGT
EMBL AC104808
GenPept
RNA Seq Atlas 306

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca