Version 5.4
Homo sapiens Gene: MAP2K2
Summary
InnateDB Gene IDBG-18293.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MAP2K2
Gene Name mitogen-activated protein kinase kinase 2
Synonyms CFC4; MAPKK2; MEK2; MKK2; PRKMK2;
Species Homo sapiens
Ensembl Gene ENSG00000126934
Encoded Proteins
IDBP-18295
mitogen-activated protein kinase kinase 2
IDBP-240705
mitogen-activated protein kinase kinase 2
IDBP-763918
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 20837746
MAP2K2 (MEK2)/PI3CD is a novel IFN-beta triggered signalling cascade that regulates secreted IL-1Ra (sIL-1Ra) expression in monocytes and this provides a rationale for an alternative, interferon (IFN)-beta-mediated pathway to induce/enhance sIL-1Ra production, dampening inflammation.
Entrez Gene
Summary The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:4090321-4124129
Strand Reverse strand
Band p13.3
Transcripts
ENST00000262948 ENSP00000262948
ENST00000394867 ENSP00000378336
ENST00000593364
ENST00000601786
ENST00000602167
ENST00000595715
ENST00000600584
ENST00000597263
ENST00000599345
ENST00000597008
ENST00000599021 ENSP00000471763
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 33 [view]
Protein-Protein 32 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004708 MAP kinase kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0030165 PDZ domain binding
GO:0032947 protein complex scaffold
GO:0043539 protein serine/threonine kinase activator activity
GO:0097110 scaffold protein binding
Biological Process
GO:0000165 MAPK cascade
GO:0000186 activation of MAPKK activity
GO:0000187 activation of MAPK activity
GO:0002224 toll-like receptor signaling pathway
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0002756 MyD88-independent toll-like receptor signaling pathway
GO:0006468 protein phosphorylation
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007264 small GTPase mediated signal transduction
GO:0007265 Ras protein signal transduction
GO:0007411 axon guidance
GO:0008286 insulin receptor signaling pathway
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0032872 regulation of stress-activated MAPK cascade
GO:0034134 toll-like receptor 2 signaling pathway
GO:0034138 toll-like receptor 3 signaling pathway
GO:0034142 toll-like receptor 4 signaling pathway
GO:0034146 toll-like receptor 5 signaling pathway
GO:0034162 toll-like receptor 9 signaling pathway
GO:0034166 toll-like receptor 10 signaling pathway
GO:0035666 TRIF-dependent toll-like receptor signaling pathway
GO:0036289 peptidyl-serine autophosphorylation
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0038123 toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 toll-like receptor TLR6:TLR2 signaling pathway
GO:0045087 innate immune response (InnateDB)
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0051403 stress-activated MAPK cascade
GO:0070371 ERK1 and ERK2 cascade
GO:0071902 positive regulation of protein serine/threonine kinase activity
GO:0090170 regulation of Golgi inheritance
GO:2000147 positive regulation of cell motility
GO:2000641 regulation of early endosome to late endosome transport
Cellular Component
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005769 early endosome
GO:0005770 late endosome
GO:0005778 peroxisomal membrane
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005874 microtubule
GO:0005911 cell-cell junction
GO:0005925 focal adhesion
GO:0005938 cell cortex
GO:0009898 cytoplasmic side of plasma membrane
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
ENSMUSG00000035027
View Gene Order
Ortholuge
SSD Ortholog
Ortholog supports species divergence
ENSBTAG00000024450
Not yet available
Ortholuge
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
NetPath_4
EGFR1 pathway
NetPath_5
ID pathway
NetPath_6
KitReceptor pathway
NetPath_7
TGF_beta_Receptor pathway
NetPath_11
TCR pathway
NetPath_12
BCR pathway
NetPath_13
IL1 pathway
NetPath_14
IL2 pathway
NetPath_17
IL5 pathway
NetPath_18
IL6 pathway
NetPath_19
IL-7 pathway
NetPath_20
IL9 pathway
NetPath_22
Leptin pathway
NetPath_24
TSLP pathway
NetPath_25
FSH pathway
NetPath_56
Prolactin pathway
REACTOME
REACT_120736
Signaling by FGFR in disease pathway
REACT_999
SHC-related events pathway
REACT_25222
MyD88 dependent cascade initiated on endosome pathway
REACT_111045
Developmental Biology pathway
REACT_11061
Signalling by NGF pathway
REACT_9020
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
REACT_115871
Signaling by EGFR in Cancer pathway
REACT_21272
Downstream signaling of activated FGFR pathway
REACT_12077
Signalling to p38 via RIT and RIN pathway
REACT_21247
FRS2-mediated cascade pathway
REACT_8005
Toll Like Receptor TLR1:TLR2 Cascade pathway
REACT_120966
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_524
SOS-mediated signalling pathway
REACT_9047
Toll Like Receptor 9 (TLR9) Cascade pathway
REACT_8006
Toll Like Receptor TLR6:TLR2 Cascade pathway
REACT_1183
ERK2 activation pathway
REACT_116005
SHC1 events in ERBB4 signaling pathway
REACT_147814
DAP12 signaling pathway
REACT_18334
NCAM signaling for neurite out-growth pathway
REACT_150359
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
REACT_115854
GRB2 events in ERBB2 signaling pathway
REACT_27215
MyD88 cascade initiated on plasma membrane pathway
REACT_12529
Signaling by VEGF pathway
REACT_9417
Signaling by EGFR pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_14797
Signaling by GPCR pathway
REACT_6802
Innate Immune System pathway
REACT_115596
Signaling by ERBB4 pathway
REACT_6783
Toll Like Receptor 3 (TLR3) Cascade pathway
REACT_150139
SHC-related events triggered by IGF1R pathway
REACT_228211
Uptake and actions of bacterial toxins pathway
REACT_111040
Signaling by SCF-KIT pathway
REACT_7980
Toll Like Receptor 2 (TLR2) Cascade pathway
REACT_12076
Frs2-mediated activation pathway
REACT_6966
Toll-Like Receptors Cascades pathway
REACT_18266
Axon guidance pathway
REACT_634
RAF/MAP kinase cascade pathway
REACT_163936
Fc epsilon receptor (FCERI) signaling pathway
REACT_111102
Signal Transduction pathway
REACT_21308
MAP kinase activation in TLR cascade pathway
REACT_332
IRS-mediated signalling pathway
REACT_12579
SHC1 events in EGFR signaling pathway
REACT_661
SHC-mediated signalling pathway
REACT_25024
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
REACT_6900
Immune System pathway
REACT_6809
MyD88-independent cascade pathway
REACT_6788
MyD88:Mal cascade initiated on plasma membrane pathway
REACT_17025
Downstream signal transduction pathway
REACT_12606
GRB2 events in EGFR signaling pathway
REACT_228024
VEGFR2 mediated cell proliferation pathway
REACT_1195
Insulin receptor signalling cascade pathway
REACT_27283
Interleukin-2 signaling pathway
REACT_22232
Signaling by Interleukins pathway
REACT_228166
VEGFA-VEGFR2 Pathway pathway
REACT_12058
Signalling to ERKs pathway
REACT_12056
NGF signalling via TRKA from the plasma membrane pathway
REACT_150203
IRS-related events triggered by IGF1R pathway
REACT_762
IRS-related events pathway
REACT_22205
L1CAM interactions pathway
REACT_115993
SHC1 events in ERBB2 signaling pathway
REACT_22272
Signal transduction by L1 pathway
REACT_150210
IGF1R signaling cascade pathway
REACT_12002
ARMS-mediated activation pathway
REACT_12005
Prolonged ERK activation events pathway
REACT_6894
Toll Like Receptor 4 (TLR4) Cascade pathway
REACT_6890
Activated TLR4 signalling pathway
REACT_9470
Signaling by FGFR pathway
REACT_12033
Signalling to RAS pathway
REACT_16888
Signaling by PDGF pathway
REACT_962
MEK activation pathway
REACT_498
Signaling by Insulin receptor pathway
REACT_115755
Signaling by ERBB2 pathway
REACT_25281
TRIF-mediated TLR3/TLR4 signaling pathway
REACT_1482
ERK activation pathway
REACT_9061
Toll Like Receptor 5 (TLR5) Cascade pathway
REACT_228255
Uptake and function of anthrax toxins pathway
REACT_116125
Disease pathway
REACT_614
RAF phosphorylates MEK pathway
REACT_9027
Toll Like Receptor 10 (TLR10) Cascade pathway
REACT_169118
Signaling by Leptin pathway
REACT_163701
FCERI mediated MAPK activation pathway
REACT_147694
DAP12 interactions pathway
KEGG
hsa04010
MAPK signaling pathway pathway
hsa04012
ErbB signaling pathway pathway
hsa04270
Vascular smooth muscle contraction pathway
hsa04370
VEGF signaling pathway pathway
hsa04540
Gap junction pathway
hsa04620
Toll-like receptor signaling pathway pathway
hsa04650
Natural killer cell mediated cytotoxicity pathway
hsa04660
T cell receptor signaling pathway pathway
hsa04662
B cell receptor signaling pathway pathway
hsa04664
Fc epsilon RI signaling pathway pathway
hsa04720
Long-term potentiation pathway
hsa04722
Neurotrophin signaling pathway pathway
hsa04730
Long-term depression pathway
hsa04810
Regulation of actin cytoskeleton pathway
hsa04910
Insulin signaling pathway pathway
hsa04912
GnRH signaling pathway pathway
hsa04916
Melanogenesis pathway
hsa05020
Prion diseases pathway
hsa05200
Pathways in cancer pathway
hsa05211
Renal cell carcinoma pathway
hsa05213
Endometrial cancer pathway
hsa05214
Glioma pathway
hsa05215
Prostate cancer pathway
hsa05216
Thyroid cancer pathway
hsa05218
Melanoma pathway
hsa05219
Bladder cancer pathway
hsa05220
Chronic myeloid leukemia pathway
hsa05221
Acute myeloid leukemia pathway
hsa05223
Non-small cell lung cancer pathway
INOH
INOH website
IGF1 signaling pathway pathway
INOH website
NGF signaling pathway pathway
INOH website
GPCR signaling pathway
INOH website
PDGF signaling pathway pathway
INOH website
IL-7 signaling pathway
INOH website
CD4 T cell receptor signaling pathway
INOH website
IL-1 signaling pathway pathway
INOH website
Toll-like receptor signaling pathway pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
B cell receptor signaling pathway
INOH website
Integrin signaling pathway pathway
INOH website
EPO signaling pathway pathway
INOH website
FGF signaling pathway pathway
INOH website
GPCR Adenosine A2A receptor signaling pathway pathway
INOH website
Insulin receptor signaling pathway
INOH website
VEGF signaling pathway pathway
INOH website
GPCR GroupI metabotropic glutamate receptor signaling pathway pathway
INOH website
HGF signaling pathway pathway
INOH website
EGF signaling pathway pathway
PID BIOCARTA
100229
Role of Ã?-arrestins in the activation and targeting of map kinases [Biocarta view]
100183
Phospholipids as signalling intermediaries [Biocarta view]
100221
Role of egf receptor transactivation by gpcrs in cardiac hypertrophy [Biocarta view]
100149
Human cytomegalovirus and map kinase pathways [Biocarta view]
100129
Il-2 receptor beta chain in t cell activation [Biocarta view]
100147
Role of erbb2 in signal transduction and oncology [Biocarta view]
100119
Keratinocyte differentiation [Biocarta view]
100036
Regulation of splicing through sam68 [Biocarta view]
100236
Angiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling [Biocarta view]
100108
Melanocyte development and pigmentation pathway [Biocarta view]
100018
Trefoil factors initiate mucosal healing [Biocarta view]
100111
Mcalpain and friends in cell motility [Biocarta view]
100162
Fmlp induced chemokine gene expression in hmc-1 cells [Biocarta view]
100242
Anthrax toxin mechanism of action [Biocarta view]
100230
Roles of Ã? arrestin dependent recruitment of src kinases in gpcr signaling [Biocarta view]
100210
Phosphorylation of mek1 by cdk5/p35 down regulates the map kinase pathway [Biocarta view]
100114
Role of mal in rho-mediated activation of srf [Biocarta view]
100113
Mapkinase signaling pathway [Biocarta view]
100029
Sprouty regulation of tyrosine kinase signals [Biocarta view]
100171
Role of erk5 in neuronal survival pathway [Biocarta view]
100206
Ceramide signaling pathway [Biocarta view]
100057
Links between pyk2 and map kinases [Biocarta view]
100170
Erk1/erk2 mapk signaling pathway [Biocarta view]
100054
Influence of ras and rho proteins on g1 to s transition [Biocarta view]
100209
Cadmium induces dna synthesis and proliferation in macrophages [Biocarta view]
100165
Fc epsilon receptor i signaling in mast cells [Biocarta view]
PID NCI
ceramide_pathway
Ceramide signaling pathway
anthraxpathway
Cellular roles of Anthrax toxin
erbb1_downstream_pathway
ErbB1 downstream signaling
kitpathway
Signaling events mediated by Stem cell factor receptor (c-Kit)
fcer1pathway
Fc-epsilon receptor I signaling in mast cells
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.592273
RefSeq NM_030662
HUGO
OMIM
CCDS CCDS12120
HPRD 03164
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca