Homo sapiens Gene: MAP2K2
InnateDB Gene IDBG-18293.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MAP2K2
Gene Name mitogen-activated protein kinase kinase 2
Synonyms CFC4; MAPKK2; MEK2; MKK2; PRKMK2
Species Homo sapiens
Ensembl Gene ENSG00000126934
Encoded Proteins
mitogen-activated protein kinase kinase 2
mitogen-activated protein kinase kinase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
MAP2K2 (MEK2)/PI3CD is a novel IFN-beta triggered signalling cascade that regulates secreted IL-1Ra (sIL-1Ra) expression in monocytes and this provides a rationale for an alternative, interferon (IFN)-beta-mediated pathway to induce/enhance sIL-1Ra production, dampening inflammation.
Entrez Gene
Summary The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:4090321-4124129
Strand Reverse strand
Band p13.3
ENST00000262948 ENSP00000262948
ENST00000394867 ENSP00000378336
ENST00000599021 ENSP00000471763
Number of Interactions This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 33 [view]
Protein-Protein 32 [view]
Protein-DNA 1 [view]
Protein-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004708 MAP kinase kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0030165 PDZ domain binding
GO:0032947 protein complex scaffold
GO:0043539 protein serine/threonine kinase activator activity
GO:0097110 scaffold protein binding
Biological Process
GO:0000165 MAPK cascade
GO:0000186 activation of MAPKK activity
GO:0000187 activation of MAPK activity
GO:0002224 toll-like receptor signaling pathway
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0002756 MyD88-independent toll-like receptor signaling pathway
GO:0006468 protein phosphorylation
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007264 small GTPase mediated signal transduction
GO:0007265 Ras protein signal transduction
GO:0007411 axon guidance
GO:0008286 insulin receptor signaling pathway
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0032872 regulation of stress-activated MAPK cascade
GO:0034134 toll-like receptor 2 signaling pathway
GO:0034138 toll-like receptor 3 signaling pathway
GO:0034142 toll-like receptor 4 signaling pathway
GO:0034146 toll-like receptor 5 signaling pathway
GO:0034162 toll-like receptor 9 signaling pathway
GO:0034166 toll-like receptor 10 signaling pathway
GO:0035666 TRIF-dependent toll-like receptor signaling pathway
GO:0036289 peptidyl-serine autophosphorylation
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0038123 toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 toll-like receptor TLR6:TLR2 signaling pathway
GO:0045087 innate immune response (InnateDB)
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0051403 stress-activated MAPK cascade
GO:0070371 ERK1 and ERK2 cascade
GO:0071902 positive regulation of protein serine/threonine kinase activity
GO:0090170 regulation of Golgi inheritance
GO:2000147 positive regulation of cell motility
GO:2000641 regulation of early endosome to late endosome transport
Cellular Component
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005769 early endosome
GO:0005770 late endosome
GO:0005778 peroxisomal membrane
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005874 microtubule
GO:0005911 cell-cell junction
GO:0005925 focal adhesion
GO:0005938 cell cortex
GO:0009898 cytoplasmic side of plasma membrane
GO:0048471 perinuclear region of cytoplasm
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
EGFR1 pathway
ID pathway
KitReceptor pathway
TGF_beta_Receptor pathway
TCR pathway
BCR pathway
IL1 pathway
IL2 pathway
IL5 pathway
IL6 pathway
IL-7 pathway
IL9 pathway
Leptin pathway
TSLP pathway
FSH pathway
Prolactin pathway
RAF phosphorylates MEK pathway
MEK activation pathway
ERK2 activation pathway
ERK activation pathway
DAP12 signaling pathway
DAP12 interactions pathway
MyD88-independent cascade pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
MyD88:Mal cascade initiated on plasma membrane pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
MyD88 dependent cascade initiated on endosome pathway
Toll Like Receptor 9 (TLR9) Cascade pathway
MyD88 cascade initiated on plasma membrane pathway
Toll Like Receptor 10 (TLR10) Cascade pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
Toll Like Receptor 5 (TLR5) Cascade pathway
Interleukin-2 signaling pathway
Frs2-mediated activation pathway
ARMS-mediated activation pathway
Signalling to p38 via RIT and RIN pathway
Signalling to RAS pathway
SOS-mediated signalling pathway
SHC1 events in EGFR signaling pathway
GRB2 events in EGFR signaling pathway
Signaling by EGFR pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
SHC1 events in ERBB4 signaling pathway
Signaling by ERBB4 pathway
SHC-mediated signalling pathway
Signaling by Insulin receptor pathway
IRS-related events triggered by IGF1R pathway
SHC-related events triggered by IGF1R pathway
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
GRB2 events in ERBB2 signaling pathway
SHC1 events in ERBB2 signaling pathway
Signaling by ERBB2 pathway
FRS2-mediated cascade pathway
Signaling by FGFR pathway
Signaling by SCF-KIT pathway
Downstream signal transduction pathway
Signaling by PDGF pathway
Signal transduction by L1 pathway
L1CAM interactions pathway
NCAM signaling for neurite out-growth pathway
Signaling by FGFR in disease pathway
SHC-related events pathway
Developmental Biology pathway
Signalling by NGF pathway
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
Signaling by EGFR in Cancer pathway
Downstream signaling of activated FGFR pathway
Signaling by VEGF pathway
Cytokine Signaling in Immune system pathway
Signaling by GPCR pathway
Innate Immune System pathway
Uptake and actions of bacterial toxins pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Toll-Like Receptors Cascades pathway
Axon guidance pathway
RAF/MAP kinase cascade pathway
Fc epsilon receptor (FCERI) signaling pathway
Signal Transduction pathway
MAP kinase activation in TLR cascade pathway
IRS-mediated signalling pathway
Immune System pathway
VEGFR2 mediated cell proliferation pathway
Insulin receptor signalling cascade pathway
Signaling by Interleukins pathway
VEGFA-VEGFR2 Pathway pathway
Signalling to ERKs pathway
NGF signalling via TRKA from the plasma membrane pathway
IRS-related events pathway
IGF1R signaling cascade pathway
Prolonged ERK activation events pathway
Activated TLR4 signalling pathway
TRIF-mediated TLR3/TLR4 signaling pathway
Uptake and function of anthrax toxins pathway
Disease pathway
Signaling by Leptin pathway
FCERI mediated MAPK activation pathway
Regulation of actin cytoskeleton pathway
GnRH signaling pathway pathway
Acute myeloid leukemia pathway
VEGF signaling pathway pathway
Fc epsilon RI signaling pathway pathway
Gap junction pathway
Non-small cell lung cancer pathway
ErbB signaling pathway pathway
Renal cell carcinoma pathway
MAPK signaling pathway pathway
Melanoma pathway
Thyroid cancer pathway
Endometrial cancer pathway
Long-term potentiation pathway
Bladder cancer pathway
Glioma pathway
Insulin signaling pathway pathway
B cell receptor signaling pathway pathway
Prostate cancer pathway
Long-term depression pathway
T cell receptor signaling pathway pathway
Toll-like receptor signaling pathway pathway
Natural killer cell mediated cytotoxicity pathway
Chronic myeloid leukemia pathway
Melanogenesis pathway
Vascular smooth muscle contraction pathway
Neurotrophin signaling pathway pathway
Prion diseases pathway
Pathways in cancer pathway
CD4 T cell receptor signaling pathway
IL-7 signaling pathway
IL-1 signaling pathway pathway
Toll-like receptor signaling pathway pathway
JAK STAT pathway and regulation pathway
B cell receptor signaling pathway
Integrin signaling pathway pathway
EPO signaling pathway pathway
FGF signaling pathway pathway
GPCR Adenosine A2A receptor signaling pathway pathway
Insulin receptor signaling pathway
VEGF signaling pathway pathway
GPCR GroupI metabotropic glutamate receptor signaling pathway pathway
HGF signaling pathway pathway
EGF signaling pathway pathway
NGF signaling pathway pathway
IGF1 signaling pathway pathway
GPCR signaling pathway
PDGF signaling pathway pathway
Ceramide signaling pathway
Cellular roles of Anthrax toxin
ErbB1 downstream signaling
Signaling events mediated by Stem cell factor receptor (c-Kit)
Fc-epsilon receptor I signaling in mast cells
UniProt Splice Variant
Entrez Gene
UniGene Hs.592273
RefSeq NM_030662
HPRD 03164
RNA Seq Atlas