Bos taurus Gene: MAP2K2
Summary
InnateDB Gene IDBG-644312.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MAP2K2
Gene Name dual specificity mitogen-activated protein kinase kinase 2
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000024450
Encoded Proteins
dual specificity mitogen-activated protein kinase kinase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
[Homo sapiens] MAP2K2 (MEK2)/PI3CD is a novel IFN-beta triggered signalling cascade that regulates secreted IL-1Ra (sIL-1Ra) expression in monocytes and this provides a rationale for an alternative, interferon (IFN)-beta-mediated pathway to induce/enhance sIL-1Ra production, dampening inflammation.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000126934:
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:21132389-21153974
Strand Forward strand
Band
Transcripts
ENSBTAT00000011377 ENSBTAP00000011377
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.
Predicted by orthology
Total 25 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004708 MAP kinase kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0030165 PDZ domain binding
GO:0032947 protein complex scaffold
GO:0043539 protein serine/threonine kinase activator activity
GO:0097110 scaffold protein binding
Biological Process
GO:0006468 protein phosphorylation
GO:0036289 peptidyl-serine autophosphorylation
GO:0071902 positive regulation of protein serine/threonine kinase activity
GO:2000147 positive regulation of cell motility
Cellular Component
GO:0005737 cytoplasm
GO:0005778 peroxisomal membrane
GO:0005783 endoplasmic reticulum
GO:0005874 microtubule
GO:0005911 cell-cell junction
GO:0009898 cytoplasmic side of plasma membrane
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
SSD Ortholog
Ortholog supports species divergence
Pathway Predictions based on Human Orthology Data
NETPATH
EGFR1 pathway
ID pathway
KitReceptor pathway
TGF_beta_Receptor pathway
TCR pathway
BCR pathway
IL1 pathway
IL2 pathway
IL5 pathway
IL6 pathway
IL-7 pathway
IL9 pathway
Leptin pathway
TSLP pathway
FSH pathway
Prolactin pathway
REACTOME
Signaling by FGFR in disease pathway
SHC-related events pathway
MyD88 dependent cascade initiated on endosome pathway
Developmental Biology pathway
Signalling by NGF pathway
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
Signaling by EGFR in Cancer pathway
Downstream signaling of activated FGFR pathway
Signalling to p38 via RIT and RIN pathway
FRS2-mediated cascade pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
SOS-mediated signalling pathway
Toll Like Receptor 9 (TLR9) Cascade pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
ERK2 activation pathway
SHC1 events in ERBB4 signaling pathway
DAP12 signaling pathway
NCAM signaling for neurite out-growth pathway
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
GRB2 events in ERBB2 signaling pathway
MyD88 cascade initiated on plasma membrane pathway
Signaling by VEGF pathway
Signaling by EGFR pathway
Cytokine Signaling in Immune system pathway
Signaling by GPCR pathway
Innate Immune System pathway
Signaling by ERBB4 pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
SHC-related events triggered by IGF1R pathway
Uptake and actions of bacterial toxins pathway
Signaling by SCF-KIT pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Frs2-mediated activation pathway
Toll-Like Receptors Cascades pathway
Axon guidance pathway
RAF/MAP kinase cascade pathway
Fc epsilon receptor (FCERI) signaling pathway
Signal Transduction pathway
MAP kinase activation in TLR cascade pathway
IRS-mediated signalling pathway
SHC1 events in EGFR signaling pathway
SHC-mediated signalling pathway
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
Immune System pathway
MyD88-independent cascade pathway
MyD88:Mal cascade initiated on plasma membrane pathway
Downstream signal transduction pathway
GRB2 events in EGFR signaling pathway
VEGFR2 mediated cell proliferation pathway
Insulin receptor signalling cascade pathway
Interleukin-2 signaling pathway
Signaling by Interleukins pathway
VEGFA-VEGFR2 Pathway pathway
Signalling to ERKs pathway
NGF signalling via TRKA from the plasma membrane pathway
IRS-related events triggered by IGF1R pathway
IRS-related events pathway
L1CAM interactions pathway
SHC1 events in ERBB2 signaling pathway
Signal transduction by L1 pathway
IGF1R signaling cascade pathway
ARMS-mediated activation pathway
Prolonged ERK activation events pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
Activated TLR4 signalling pathway
Signaling by FGFR pathway
Signalling to RAS pathway
Signaling by PDGF pathway
MEK activation pathway
Signaling by Insulin receptor pathway
Signaling by ERBB2 pathway
TRIF-mediated TLR3/TLR4 signaling pathway
ERK activation pathway
Toll Like Receptor 5 (TLR5) Cascade pathway
Uptake and function of anthrax toxins pathway
Disease pathway
RAF phosphorylates MEK pathway
Toll Like Receptor 10 (TLR10) Cascade pathway
Signaling by Leptin pathway
FCERI mediated MAPK activation pathway
DAP12 interactions pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Innate Immune System pathway
Signaling by ERBB2 pathway
Disease pathway
SHC-related events pathway
RAF/MAP kinase cascade pathway
Signaling by GPCR pathway
Signaling by Insulin receptor pathway
Interleukin-2 signaling pathway
RAF phosphorylates MEK pathway
MyD88 cascade initiated on plasma membrane pathway
Signaling by VEGF pathway
Signaling by FGFR in disease pathway
Signaling by ERBB4 pathway
Signaling by SCF-KIT pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
SHC1 events in ERBB2 signaling pathway
Cytokine Signaling in Immune system pathway
VEGFR2 mediated cell proliferation pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
MAP kinase activation in TLR cascade pathway
Immune System pathway
Toll Like Receptor 5 (TLR5) Cascade pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
SHC-mediated signalling pathway
Downstream signal transduction pathway
Downstream signaling of activated FGFR pathway
ERK activation pathway
SHC1 events in ERBB4 signaling pathway
Signalling to RAS pathway
SHC1 events in EGFR signaling pathway
Toll Like Receptor 9 (TLR9) Cascade pathway
Signaling by EGFR pathway
Frs2-mediated activation pathway
Insulin receptor signalling cascade pathway
IRS-related events triggered by IGF1R pathway
IGF1R signaling cascade pathway
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
VEGFA-VEGFR2 Pathway pathway
Axon guidance pathway
Fc epsilon receptor (FCERI) signaling pathway
Toll-Like Receptors Cascades pathway
Signalling to ERKs pathway
Signaling by Interleukins pathway
MyD88 dependent cascade initiated on endosome pathway
Signal transduction by L1 pathway
L1CAM interactions pathway
Signalling by NGF pathway
Signaling by PDGF pathway
FRS2-mediated cascade pathway
Developmental Biology pathway
SOS-mediated signalling pathway
Activated TLR4 signalling pathway
IRS-related events pathway
NGF signalling via TRKA from the plasma membrane pathway
IRS-mediated signalling pathway
ERK2 activation pathway
ARMS-mediated activation pathway
MyD88-independent cascade pathway
Signal Transduction pathway
GRB2 events in ERBB2 signaling pathway
Signaling by Leptin pathway
Prolonged ERK activation events pathway
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
MyD88:Mal cascade initiated on plasma membrane pathway
Signaling by FGFR pathway
GRB2 events in EGFR signaling pathway
TRIF-mediated TLR3/TLR4 signaling pathway
FCERI mediated MAPK activation pathway
MEK activation pathway
SHC-related events triggered by IGF1R pathway
Signaling by EGFR in Cancer pathway
NCAM signaling for neurite out-growth pathway
Signalling to p38 via RIT and RIN pathway
DAP12 interactions pathway
DAP12 signaling pathway
Toll Like Receptor 10 (TLR10) Cascade pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
KEGG
MAPK signaling pathway pathway
ErbB signaling pathway pathway
Vascular smooth muscle contraction pathway
VEGF signaling pathway pathway
Gap junction pathway
Toll-like receptor signaling pathway pathway
Natural killer cell mediated cytotoxicity pathway
T cell receptor signaling pathway pathway
B cell receptor signaling pathway pathway
Fc epsilon RI signaling pathway pathway
Long-term potentiation pathway
Neurotrophin signaling pathway pathway
Long-term depression pathway
Regulation of actin cytoskeleton pathway
Insulin signaling pathway pathway
GnRH signaling pathway pathway
Melanogenesis pathway
Prion diseases pathway
Pathways in cancer pathway
Renal cell carcinoma pathway
Endometrial cancer pathway
Glioma pathway
Prostate cancer pathway
Thyroid cancer pathway
Melanoma pathway
Bladder cancer pathway
Chronic myeloid leukemia pathway
Acute myeloid leukemia pathway
Non-small cell lung cancer pathway
MAPK signaling pathway pathway
ErbB signaling pathway pathway
Vascular smooth muscle contraction pathway
VEGF signaling pathway pathway
Gap junction pathway
Toll-like receptor signaling pathway pathway
Natural killer cell mediated cytotoxicity pathway
T cell receptor signaling pathway pathway
B cell receptor signaling pathway pathway
Fc epsilon RI signaling pathway pathway
Long-term potentiation pathway
Neurotrophin signaling pathway pathway
Long-term depression pathway
Regulation of actin cytoskeleton pathway
Insulin signaling pathway pathway
GnRH signaling pathway pathway
Melanogenesis pathway
Prion diseases pathway
Pathways in cancer pathway
Renal cell carcinoma pathway
Endometrial cancer pathway
Glioma pathway
Prostate cancer pathway
Thyroid cancer pathway
Melanoma pathway
Bladder cancer pathway
Chronic myeloid leukemia pathway
Acute myeloid leukemia pathway
Non-small cell lung cancer pathway
INOH
IGF1 signaling pathway pathway
NGF signaling pathway pathway
GPCR signaling pathway
PDGF signaling pathway pathway
IL-7 signaling pathway
CD4 T cell receptor signaling pathway
IL-1 signaling pathway pathway
Toll-like receptor signaling pathway pathway
JAK STAT pathway and regulation pathway
B cell receptor signaling pathway
Integrin signaling pathway pathway
EPO signaling pathway pathway
FGF signaling pathway pathway
GPCR Adenosine A2A receptor signaling pathway pathway
Insulin receptor signaling pathway
VEGF signaling pathway pathway
GPCR GroupI metabotropic glutamate receptor signaling pathway pathway
HGF signaling pathway pathway
EGF signaling pathway pathway
NGF signaling pathway pathway
GPCR signaling pathway
PDGF signaling pathway pathway
CD4 T cell receptor signaling pathway
IL-7 signaling pathway
IL-1 signaling pathway pathway
Toll-like receptor signaling pathway pathway
JAK STAT pathway and regulation pathway
B cell receptor signaling pathway
Integrin signaling pathway pathway
FGF8 signaling (Mouse) pathway
EPO signaling pathway pathway
FGF signaling pathway pathway
GPCR Adenosine A2A receptor signaling pathway pathway
Insulin receptor signaling pathway
VEGF signaling pathway pathway
GPCR GroupI metabotropic glutamate receptor signaling pathway pathway
HGF signaling pathway pathway
EGF signaling pathway pathway
PID BIOCARTA
Role of ?-arrestins in the activation and targeting of map kinases [Biocarta view]
Phospholipids as signalling intermediaries [Biocarta view]
Role of egf receptor transactivation by gpcrs in cardiac hypertrophy [Biocarta view]
Human cytomegalovirus and map kinase pathways [Biocarta view]
Il-2 receptor beta chain in t cell activation [Biocarta view]
Role of erbb2 in signal transduction and oncology [Biocarta view]
Keratinocyte differentiation [Biocarta view]
Regulation of splicing through sam68 [Biocarta view]
Angiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling [Biocarta view]
Melanocyte development and pigmentation pathway [Biocarta view]
Trefoil factors initiate mucosal healing [Biocarta view]
Mcalpain and friends in cell motility [Biocarta view]
Fmlp induced chemokine gene expression in hmc-1 cells [Biocarta view]
Anthrax toxin mechanism of action [Biocarta view]
Roles of ? arrestin dependent recruitment of src kinases in gpcr signaling [Biocarta view]
Phosphorylation of mek1 by cdk5/p35 down regulates the map kinase pathway [Biocarta view]
Role of mal in rho-mediated activation of srf [Biocarta view]
Mapkinase signaling pathway [Biocarta view]
Sprouty regulation of tyrosine kinase signals [Biocarta view]
Role of erk5 in neuronal survival pathway [Biocarta view]
Ceramide signaling pathway [Biocarta view]
Links between pyk2 and map kinases [Biocarta view]
Erk1/erk2 mapk signaling pathway [Biocarta view]
Influence of ras and rho proteins on g1 to s transition [Biocarta view]
Cadmium induces dna synthesis and proliferation in macrophages [Biocarta view]
Fc epsilon receptor i signaling in mast cells [Biocarta view]
PID NCI
Ceramide signaling pathway
Cellular roles of Anthrax toxin
ErbB1 downstream signaling
Signaling events mediated by Stem cell factor receptor (c-Kit)
Fc-epsilon receptor I signaling in mast cells
Cross-References
SwissProt
TrEMBL Q17QH2
UniProt Splice Variant
Entrez Gene 510434
UniGene Bt.8367
RefSeq NM_001038071
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC118362 DAAA02019622 DAAA02019623
GenPept AAI18363
RNA Seq Atlas 510434
Transcript Frequencies
Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

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