InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ruvbl2

Summary

InnateDB Gene

IDBG-182997.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ruvbl2

Gene Name

RuvB-like protein 2

Synonyms

mp47; p47

Species

Mus musculus

Ensembl Gene

ENSMUSG00000003868

Encoded Proteins

IDBP-182999

RuvB-like protein 2

IDBP-265961

RuvB-like protein 2

IDBP-538619

RuvB-like protein 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000183207:
This gene encodes the second human homologue of the bacterial RuvB gene. Bacterial RuvB protein is a DNA helicase essential for homologous recombination and DNA double-strand break repair. Functional analysis showed that this gene product has both ATPase and DNA helicase activities. This gene is physically linked to the CGB/LHB gene cluster on chromosome 19q13.3, and is very close (55 nt) to the LHB gene, in the opposite orientation. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:45421852-45438096

Strand

Reverse strand

Band

Transcripts

ENSMUST00000033087	ENSMUSP00000033087
ENSMUST00000107771	ENSMUSP00000103400
ENSMUST00000141761	ENSMUSP00000118973

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 195 interaction(s) predicted by orthology.

Experimentally validated
Total	24 [view]
Protein-Protein	24 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	195 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0003678	DNA helicase activity
GO:0003684	damaged DNA binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016887	ATPase activity
GO:0017111	nucleoside-triphosphatase activity
GO:0031490	chromatin DNA binding
GO:0042802	identical protein binding
GO:0043141	ATP-dependent 5'-3' DNA helicase activity

Biological Process

GO:0006200	ATP catabolic process
GO:0006260	DNA replication
GO:0006281	DNA repair
GO:0006310	DNA recombination
GO:0006338	chromatin remodeling
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0032508	DNA duplex unwinding
GO:0034644	cellular response to UV
GO:0035066	positive regulation of histone acetylation
GO:0043967	histone H4 acetylation
GO:0043968	histone H2A acetylation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0071169	establishment of protein localization to chromatin
GO:0071392	cellular response to estradiol stimulus
GO:0071733	transcriptional activation by promoter-enhancer looping
GO:0071899	negative regulation of estrogen receptor binding

Cellular Component

GO:0000812	Swr1 complex
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005719	nuclear euchromatin
GO:0005737	cytoplasm
GO:0030529	ribonucleoprotein complex
GO:0031011	Ino80 complex
GO:0035267	NuA4 histone acetyltransferase complex
GO:0070062	extracellular vesicular exosome
GO:0071339	MLL1 complex