Version 5.4
Mus musculus Gene: Sec31a
Summary
InnateDB Gene IDBG-183023.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sec31a
Gene Name Sec31 homolog A (S. cerevisiae)
Synonyms 1810024J13Rik; ABP125; ABP130; AU042160; HSPC275; Sec31l1
Species Mus musculus
Ensembl Gene ENSMUSG00000035325
Encoded Proteins
IDBP-183029
Sec31 homolog A (S. cerevisiae)
IDBP-788552
Sec31 homolog A (S. cerevisiae)
IDBP-788554
Sec31 homolog A (S. cerevisiae)
IDBP-788555
Sec31 homolog A (S. cerevisiae)
IDBP-788557
Sec31 homolog A (S. cerevisiae)
IDBP-788558
Sec31 homolog A (S. cerevisiae)
IDBP-788559
Sec31 homolog A (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000138674:
The protein encoded by this gene is similar to yeast Sec31 protein. Yeast Sec31 protein is known to be a component of the COPII protein complex which is responsible for vesicle budding from endoplasmic reticulum (ER). This protein was found to colocalize with SEC13, one of the other components of COPII , in the subcellular structures corresponding to the vesicle transport function. An immunodepletion experiment confirmed that this protein is required for ER-Golgi transport. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:100361649-100416234
Strand Reverse strand
Band E4
Transcripts
ENSMUST00000094578 ENSMUSP00000092157
ENSMUST00000182569
ENSMUST00000182433 ENSMUSP00000138366
ENSMUST00000182886 ENSMUSP00000138213
ENSMUST00000182988 ENSMUSP00000138571
ENSMUST00000182664
ENSMUST00000182812 ENSMUSP00000138507
ENSMUST00000182002 ENSMUSP00000138428
ENSMUST00000183247 ENSMUSP00000138129
ENSMUST00000182850
ENSMUST00000182171
ENSMUST00000182144
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 18 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0048306 calcium-dependent protein binding
Biological Process
GO:0015031 protein transport
GO:0016192 vesicle-mediated transport
GO:0051592 response to calcium ion
Cellular Component
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0012507 ER to Golgi transport vesicle membrane
GO:0030120 vesicle coat
GO:0030134 ER to Golgi transport vesicle
GO:0043231 intracellular membrane-bounded organelle
GO:0048471 perinuclear region of cytoplasm
GO:0070971 endoplasmic reticulum exit site
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000138674
View Gene Order
ENSBTAG00000020525
Not yet available
Pathways
NETPATH
REACTOME
REACT_205304
COPII (Coat Protein 2) Mediated Vesicle Transport pathway
REACT_236645
Class I MHC mediated antigen processing & presentation pathway
REACT_206143
Transport to the Golgi and subsequent modification pathway
REACT_209837
Membrane Trafficking pathway
REACT_239697
Unfolded Protein Response (UPR) pathway
REACT_230745
Immune System pathway
REACT_247926
Metabolism of proteins pathway
REACT_236283
Post-translational protein modification pathway
REACT_231085
IRE1alpha activates chaperones pathway
REACT_196550
MHC class II antigen presentation pathway
REACT_203486
ER to Golgi Transport pathway
REACT_237472
Asparagine N-linked glycosylation pathway
REACT_229531
Adaptive Immune System pathway
REACT_106572
XBP1(S) activates chaperone genes pathway
REACT_246972
Antigen Presentation: Folding, assembly and peptide loading of class I MHC pathway
KEGG
mmu04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_75795
Antigen Presentation: Folding, assembly and peptide loading of class I MHC pathway
REACT_121399
MHC class II antigen presentation pathway
REACT_12507
COPII (Coat Protein 2) Mediated Vesicle Transport pathway
REACT_25046
Transport to the Golgi and subsequent modification pathway
REACT_18273
XBP1(S) activates chaperone genes pathway
REACT_18368
IRE1alpha activates chaperones pathway
REACT_22426
Asparagine N-linked glycosylation pathway
REACT_18356
Unfolded Protein Response (UPR) pathway
REACT_22161
Post-translational protein modification pathway
REACT_11203
ER to Golgi Transport pathway
REACT_17015
Metabolism of proteins pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_75820
Class I MHC mediated antigen processing & presentation pathway
REACT_11123
Membrane Trafficking pathway
KEGG
hsa04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 69162
UniGene
RefSeq NM_026969 XM_006535202
OMIM
CCDS CCDS51573
HPRD
IMGT
MGI ID MGI:1916412
MGI Symbol Sec31a
EMBL
GenPept
RNA Seq Atlas 69162

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca