Mus musculus Gene: Itga4
Summary
InnateDB Gene IDBG-183203.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Itga4
Gene Name integrin alpha 4
Synonyms CD49D; Itga4B
Species Mus musculus
Ensembl Gene ENSMUSG00000027009
Encoded Proteins
integrin alpha 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000115232:
The product of this gene belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an alpha 4 chain. Unlike other integrin alpha chains, alpha 4 neither contains an I-domain, nor undergoes disulfide-linked cleavage. Alpha 4 chain associates with either beta 1 chain or beta 7 chain. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:79255426-79333123
Strand Forward strand
Band C3
Transcripts
ENSMUST00000099972 ENSMUSP00000099718
ENSMUST00000155105
ENSMUST00000141094
ENSMUST00000135919
ENSMUST00000126312
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 421 interaction(s) predicted by orthology.
Predicted by orthology
Total 421 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001968 fibronectin binding
GO:0005515 protein binding
GO:0050839 cell adhesion molecule binding
Biological Process
GO:0001974 blood vessel remodeling
GO:0007155 cell adhesion
GO:0007157 heterophilic cell-cell adhesion
GO:0007159 leukocyte cell-cell adhesion
GO:0007229 integrin-mediated signaling pathway
GO:0007507 heart development
GO:0016477 cell migration
GO:0060324 face development
GO:0060710 chorio-allantoic fusion
GO:0072678 T cell migration
GO:0090074 negative regulation of protein homodimerization activity
Cellular Component
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0008305 integrin complex
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
KEGG
Cell adhesion molecules (CAMs) pathway
ECM-receptor interaction pathway
Hematopoietic cell lineage pathway
Regulation of actin cytoskeleton pathway
Leukocyte transendothelial migration pathway
Focal adhesion pathway
Arrhythmogenic right ventricular cardiomyopathy (ARVC) pathway
Hypertrophic cardiomyopathy (HCM) pathway
Dilated cardiomyopathy pathway
Intestinal immune network for IgA production pathway
Leishmaniasis pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway
Cell surface interactions at the vascular wall pathway
Integrin cell surface interactions pathway
Extracellular matrix organization pathway
Adaptive Immune System pathway
Immune System pathway
Hemostasis pathway
KEGG
Regulation of actin cytoskeleton pathway
Hematopoietic cell lineage pathway
Cell adhesion molecules (CAMs) pathway
ECM-receptor interaction pathway
Leukocyte transendothelial migration pathway
Focal adhesion pathway
Arrhythmogenic right ventricular cardiomyopathy (ARVC) pathway
Hypertrophic cardiomyopathy (HCM) pathway
Dilated cardiomyopathy pathway
Intestinal immune network for IgA production pathway
Leishmaniasis pathway
INOH
Integrin signaling pathway pathway
PID NCI
Beta1 integrin cell surface interactions
Integrin family cell surface interactions
VEGFR3 signaling in lymphatic endothelium
Alpha4 beta1 integrin signaling events
a4b7 Integrin signaling
Beta5 beta6 beta7 and beta8 integrin cell surface interactions
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.31903 Mm.378227 Mm.410644
RefSeq NM_010576
OMIM
CCDS CCDS16168
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas