InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ITGA4

Summary

InnateDB Gene

IDBG-639925.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ITGA4

Gene Name

integrin alpha-4 precursor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000009256

Encoded Proteins

IDBP-692146

integrin alpha-4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000115232:
The product of this gene belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an alpha 4 chain. Unlike other integrin alpha chains, alpha 4 neither contains an I-domain, nor undergoes disulfide-linked cleavage. Alpha 4 chain associates with either beta 1 chain or beta 7 chain. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:15115673-15207508

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000012194

ENSBTAP00000012194

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 394 interaction(s) predicted by orthology.

Predicted by orthology
Total	394 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001968	fibronectin binding
GO:0005515	protein binding
GO:0050839	cell adhesion molecule binding

Biological Process

GO:0001974	blood vessel remodeling
GO:0007155	cell adhesion
GO:0007157	heterophilic cell-cell adhesion
GO:0007159	leukocyte cell-cell adhesion
GO:0007229	integrin-mediated signaling pathway
GO:0007507	heart development
GO:0016477	cell migration
GO:0060324	face development
GO:0060710	chorio-allantoic fusion
GO:0072678	T cell migration
GO:0090074	negative regulation of protein homodimerization activity

Cellular Component

GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0008305	integrin complex
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome