Mus musculus Gene: Accn2
Summary
InnateDB Gene IDBG-183645.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Accn2
Gene Name amiloride-sensitive cation channel 2, neuronal
Synonyms Accn2; AI843610; ASIC; ASIC1a; B530003N02Rik; BNaC2;
Species Mus musculus
Ensembl Gene ENSMUSG00000023017
Encoded Proteins
amiloride-sensitive cation channel 2, neuronal
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000110881:
This gene encodes a member of the acid-sensing ion channel (ASIC) family of proteins, which are part of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. Members of the ASIC family are sensitive to amiloride and function in neurotransmission. The encoded proteins function in learning, pain transduction, touch sensation, and development of memory and fear. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:99670718-99701127
Strand Forward strand
Band F1
Transcripts
ENSMUST00000023758 ENSMUSP00000023758
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005261 cation channel activity
GO:0005272 sodium channel activity
GO:0005515 protein binding
GO:0015280 ligand-gated sodium channel activity
GO:0022839 ion gated channel activity
GO:0044736 acid-sensing ion channel activity
Biological Process
GO:0006812 cation transport
GO:0006814 sodium ion transport
GO:0007613 memory
GO:0008306 associative learning
GO:0010447 response to acidity
GO:0034220 ion transmembrane transport
GO:0035725 sodium ion transmembrane transport
GO:0042391 regulation of membrane potential
GO:0046929 negative regulation of neurotransmitter secretion
GO:0050915 sensory perception of sour taste
GO:0070207 protein homotrimerization
GO:0070588 calcium ion transmembrane transport
GO:0071467 cellular response to pH
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0045202 synapse
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Stimuli-sensing channels pathway
Ion channel transport pathway
Transmembrane transport of small molecules pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Transmembrane transport of small molecules pathway
Stimuli-sensing channels pathway
Ion channel transport pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q6NXK8
TrEMBL I6L9A4
UniProt Splice Variant
Entrez Gene 11419
UniGene Mm.440107
RefSeq NM_009597 XM_006520297 XM_006520298
OMIM
CCDS CCDS27826
HPRD
IMGT
MGI ID MGI:1194915
MGI Symbol Asic1
EMBL AB208022 BC031915 BC067025
GenPept AAH31915 AAH67025 BAD97849
RNA Seq Atlas 11419