Homo sapiens Gene: ASIC1
Summary
InnateDB Gene IDBG-32261.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ASIC1
Gene Name acid-sensing (proton-gated) ion channel 1
Synonyms ACCN2; ASIC; BNaC2;
Species Homo sapiens
Ensembl Gene ENSG00000110881
Encoded Proteins
amiloride-sensitive cation channel 2, neuronal
amiloride-sensitive cation channel 2, neuronal
amiloride-sensitive cation channel 2, neuronal
amiloride-sensitive cation channel 2, neuronal
amiloride-sensitive cation channel 2, neuronal
amiloride-sensitive cation channel 2, neuronal
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the acid-sensing ion channel (ASIC) family of proteins, which are part of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. Members of the ASIC family are sensitive to amiloride and function in neurotransmission. The encoded proteins function in learning, pain transduction, touch sensation, and development of memory and fear. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:50057548-50083611
Strand Forward strand
Band q13.12
Transcripts
ENST00000228468 ENSP00000228468
ENST00000447966 ENSP00000400228
ENST00000453327 ENSP00000402896
ENST00000550558 ENSP00000448263
ENST00000551199
ENST00000552438 ENSP00000450247
ENST00000549792
ENST00000548350
ENST00000552633 ENSP00000446863
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005261 cation channel activity
GO:0005272 sodium channel activity
GO:0005515 protein binding
GO:0015280 ligand-gated sodium channel activity
GO:0022839 ion gated channel activity
GO:0044736 acid-sensing ion channel activity
Biological Process
GO:0006810 transport
GO:0006812 cation transport
GO:0006814 sodium ion transport
GO:0007165 signal transduction
GO:0007613 memory
GO:0008306 associative learning
GO:0009268 response to pH
GO:0010447 response to acidity
GO:0034220 ion transmembrane transport
GO:0035725 sodium ion transmembrane transport
GO:0042391 regulation of membrane potential
GO:0046929 negative regulation of neurotransmitter secretion
GO:0050915 sensory perception of sour taste
GO:0055085 transmembrane transport
GO:0070207 protein homotrimerization
GO:0070588 calcium ion transmembrane transport
GO:0071467 cellular response to pH
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0045202 synapse
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Transmembrane transport of small molecules pathway
Stimuli-sensing channels pathway
Ion channel transport pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL F8VSK4
UniProt Splice Variant
Entrez Gene 41
UniGene Hs.274361
RefSeq NM_020039 NM_001095 NM_001256830 XM_006719397
HUGO HGNC:100
OMIM 602866
CCDS CCDS8796 CCDS44876 CCDS58228
HPRD 04182
IMGT
EMBL AC025154
GenPept
RNA Seq Atlas 41