Version 5.4
Mus musculus Gene: Rbbp7
Summary
InnateDB Gene IDBG-183758.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rbbp7
Gene Name retinoblastoma binding protein 7
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000031353
Encoded Proteins
IDBP-183760
retinoblastoma binding protein 7
IDBP-256243
retinoblastoma binding protein 7
IDBP-256245
retinoblastoma binding protein 7
IDBP-537485
retinoblastoma binding protein 7
IDBP-542032
retinoblastoma binding protein 7
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000102054:
This protein is a ubiquitously expressed nuclear protein and belongs to a highly conserved subfamily of WD-repeat proteins. It is found among several proteins that binds directly to retinoblastoma protein, which regulates cell proliferation. The encoded protein is found in many histone deacetylase complexes, including mSin3 co-repressor complex. It is also present in protein complexes involved in chromatin assembly. This protein can interact with BRCA1 tumor-suppressor gene and may have a role in the regulation of cell proliferation and differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome X:162760402-162779092
Strand Forward strand
Band F4
Transcripts
ENSMUST00000033720 ENSMUSP00000033720
ENSMUST00000112327 ENSMUSP00000107946
ENSMUST00000112326 ENSMUSP00000107945
ENSMUST00000138791 ENSMUSP00000114734
ENSMUST00000143681 ENSMUSP00000115354
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
They are also associated with 86 interaction(s) predicted by orthology.
Experimentally validated
Total 34 [view]
Protein-Protein 34 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 86 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0005515 protein binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006260 DNA replication
GO:0006338 chromatin remodeling
GO:0006351 transcription, DNA-templated
GO:0030308 negative regulation of cell growth
GO:0045892 negative regulation of transcription, DNA-templated
GO:0070370 cellular heat acclimation
Cellular Component
GO:0005634 nucleus
GO:0016581 NuRD complex
GO:0035098 ESC/E(Z) complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000102054
View Gene Order
ENSBTAG00000002820
Not yet available
Pathways
NETPATH
REACTOME
REACT_245058
RNA Polymerase I Transcription pathway
REACT_188970
Oxidative Stress Induced Senescence pathway
REACT_244415
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
REACT_200794
Mus musculus biological processes pathway
REACT_200667
NoRC negatively regulates rRNA expression pathway
REACT_218274
Chromatin organization pathway
REACT_233453
Chromosome Maintenance pathway
REACT_188957
Cellular responses to stress pathway
REACT_226917
HATs acetylate histones pathway
REACT_222475
PRC2 methylates histones and DNA pathway
REACT_188804
Cell Cycle pathway
REACT_214440
NoRC negatively regulates rRNA expression pathway
REACT_202766
Chromatin modifying enzymes pathway
REACT_188820
Cellular Senescence pathway
REACT_205737
Epigenetic regulation of gene expression pathway
REACT_233572
Gene Expression pathway
REACT_207809
Negative epigenetic regulation of rRNA expression pathway
REACT_198595
Nucleosome assembly pathway
REACT_198597
Deposition of new CENPA-containing nucleosomes at the centromere pathway
REACT_244207
RMTs methylate histone arginines pathway
REACT_257106
HDACs deacetylate histones pathway
REACT_240511
RNA Polymerase I Promoter Clearance pathway
REACT_235780
RNA Polymerase I Transcription Initiation pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
REACT_22186
Deposition of new CENPA-containing nucleosomes at the centromere pathway
REACT_953
RNA Polymerase I Transcription Initiation pathway
REACT_172610
HATs acetylate histones pathway
REACT_120956
Cellular responses to stress pathway
REACT_200808
PRC2 methylates histones and DNA pathway
REACT_1309
RNA Polymerase I Transcription pathway
REACT_22172
Chromosome Maintenance pathway
REACT_22344
Nucleosome assembly pathway
REACT_200857
Epigenetic regulation of gene expression pathway
REACT_1974
RNA Polymerase I Promoter Clearance pathway
REACT_115566
Cell Cycle pathway
REACT_228222
HDACs deacetylate histones pathway
REACT_169274
Cellular Senescence pathway
REACT_172623
Chromatin organization pathway
REACT_228108
RMTs methylate histone arginines pathway
REACT_172633
Chromatin modifying enzymes pathway
REACT_21352
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
REACT_169436
Oxidative Stress Induced Senescence pathway
REACT_71
Gene Expression pathway
REACT_213048
Epigenetic regulation of gene expression pathway
REACT_224944
Nucleosome assembly pathway
REACT_203707
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
REACT_217981
Deposition of new CENPA-containing nucleosomes at the centromere pathway
REACT_207088
RNA Polymerase I Transcription pathway
REACT_206069
Cellular responses to stress pathway
REACT_226022
Gene Expression pathway
REACT_207632
Chromatin organization pathway
REACT_248114
HDACs deacetylate histones pathway
REACT_214934
Cell Cycle pathway
REACT_215025
Cellular Senescence pathway
REACT_225657
Oxidative Stress Induced Senescence pathway
REACT_219482
HATs acetylate histones pathway
REACT_208197
RNA Polymerase I Transcription Initiation pathway
REACT_227796
Chromosome Maintenance pathway
REACT_207393
PRC2 methylates histones and DNA pathway
REACT_243659
RMTs methylate histone arginines pathway
REACT_219488
RNA Polymerase I Promoter Clearance pathway
REACT_227044
Chromatin modifying enzymes pathway
KEGG
INOH
PID NCI
hdac_classi_pathway
Signaling events mediated by HDAC Class I
smad2_3nuclearpathway
Regulation of nuclear SMAD2/3 signaling
hedgehog_glipathway
Hedgehog signaling events mediated by Gli proteins
telomerasepathway
Regulation of Telomerase
Cross-References
SwissProt
TrEMBL A2AFJ1
UniProt Splice Variant
Entrez Gene 245688
UniGene Mm.270186
RefSeq NM_009031
OMIM
CCDS CCDS30509
HPRD
IMGT
MGI ID MGI:1194910
MGI Symbol Rbbp7
EMBL AL672123
GenPept
RNA Seq Atlas 245688

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca