Version 5.4
Homo sapiens Gene: RBBP7
Summary
InnateDB Gene IDBG-47673.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RBBP7
Gene Name retinoblastoma binding protein 7
Synonyms RbAp46
Species Homo sapiens
Ensembl Gene ENSG00000102054
Encoded Proteins
IDBP-47675
retinoblastoma binding protein 7
IDBP-47681
retinoblastoma binding protein 7
IDBP-292811
retinoblastoma binding protein 7
IDBP-363121
retinoblastoma binding protein 7
IDBP-363166
retinoblastoma binding protein 7
IDBP-363172
retinoblastoma binding protein 7
IDBP-478186
retinoblastoma binding protein 7
IDBP-476014
retinoblastoma binding protein 7
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This protein is a ubiquitously expressed nuclear protein and belongs to a highly conserved subfamily of WD-repeat proteins. It is found among several proteins that binds directly to retinoblastoma protein, which regulates cell proliferation. The encoded protein is found in many histone deacetylase complexes, including mSin3 co-repressor complex. It is also present in protein complexes involved in chromatin assembly. This protein can interact with BRCA1 tumor-suppressor gene and may have a role in the regulation of cell proliferation and differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome X:16839283-16870414
Strand Reverse strand
Band p22.2
Transcripts
ENST00000380087 ENSP00000369427
ENST00000330735
ENST00000380084 ENSP00000369424
ENST00000404022 ENSP00000386068
ENST00000425696 ENSP00000415747
ENST00000444437 ENSP00000402796
ENST00000416035 ENSP00000392714
ENST00000465244
ENST00000481586
ENST00000486166
ENST00000468092 ENSP00000417791
ENST00000493145 ENSP00000417507
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 155 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
Experimentally validated
Total 155 [view]
Protein-Protein 155 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 17 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0005515 protein binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006260 DNA replication
GO:0006325 chromatin organization
GO:0006334 nucleosome assembly
GO:0006351 transcription, DNA-templated
GO:0007275 multicellular organismal development
GO:0008283 cell proliferation
GO:0030308 negative regulation of cell growth
GO:0034080 centromere-specific nucleosome assembly
GO:0045892 negative regulation of transcription, DNA-templated
GO:0070370 cellular heat acclimation
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0016581 NuRD complex
GO:0035098 ESC/E(Z) complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031353
View Gene Order
ENSBTAG00000002820
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
REACT_22186
Deposition of new CENPA-containing nucleosomes at the centromere pathway
REACT_953
RNA Polymerase I Transcription Initiation pathway
REACT_172610
HATs acetylate histones pathway
REACT_120956
Cellular responses to stress pathway
REACT_200808
PRC2 methylates histones and DNA pathway
REACT_1309
RNA Polymerase I Transcription pathway
REACT_22172
Chromosome Maintenance pathway
REACT_22344
Nucleosome assembly pathway
REACT_200857
Epigenetic regulation of gene expression pathway
REACT_1974
RNA Polymerase I Promoter Clearance pathway
REACT_115566
Cell Cycle pathway
REACT_228222
HDACs deacetylate histones pathway
REACT_169274
Cellular Senescence pathway
REACT_172623
Chromatin organization pathway
REACT_228108
RMTs methylate histone arginines pathway
REACT_172633
Chromatin modifying enzymes pathway
REACT_21352
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
REACT_169436
Oxidative Stress Induced Senescence pathway
REACT_71
Gene Expression pathway
KEGG
INOH
PID NCI
hdac_classi_pathway
Signaling events mediated by HDAC Class I
smad2_3nuclearpathway
Regulation of nuclear SMAD2/3 signaling
hedgehog_glipathway
Hedgehog signaling events mediated by Gli proteins
telomerasepathway
Regulation of Telomerase
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.495755
RefSeq NM_001198719 NM_002893
HUGO
OMIM
CCDS CCDS14179 CCDS56598
HPRD 04231
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca