InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Arl1

Summary

InnateDB Gene

IDBG-183784.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Arl1

Gene Name

ADP-ribosylation factor-like 1

Synonyms

2310008D22Rik; AU019749

Species

Mus musculus

Ensembl Gene

ENSMUSG00000060904

Encoded Proteins

IDBP-183786

ADP-ribosylation factor-like 1

IDBP-274621

ADP-ribosylation factor-like 1

IDBP-625289

ADP-ribosylation factor-like 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000120805:
The protein encoded by this gene belongs to the ARL (ADP-ribosylation factor-like) family of proteins, which are structurally related to ADP-ribosylation factors (ARFs). ARFs, described as activators of cholera toxin (CT) ADP-ribosyltransferase activity, regulate intracellular vesicular membrane trafficking, and stimulate a phospholipase D (PLD) isoform. Although, ARL proteins were initially thought not to activate CT or PLD, later work showed that they are weak stimulators of PLD and CT in a phospholipid dependent manner. [provided by RefSeq, Jul 2008]
The protein encoded by this gene belongs to the ARL (ADP-ribosylation factor-like) family of proteins, which are structurally related to ADP-ribosylation factors (ARFs). ARFs, described as activators of cholera toxin (CT) ADP-ribosyltransferase activity, regulate intracellular vesicular membrane trafficking, and stimulate a phospholipase D (PLD) isoform. Although, ARL proteins were initially thought not to activate CT or PLD, later work showed that they are weak stimulators of PLD and CT in a phospholipid dependent manner. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:88730858-88744094

Strand

Forward strand

Band

Transcripts

ENSMUST00000080379	ENSMUSP00000079246
ENSMUST00000116234	ENSMUSP00000111942
ENSMUST00000170137	ENSMUSP00000127889

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0004871	signal transducer activity
GO:0005525	GTP binding
GO:0008047	enzyme activator activity
GO:0019001	guanyl nucleotide binding
GO:0019904	protein domain specific binding
GO:0031683	G-protein beta/gamma-subunit complex binding
GO:0046872	metal ion binding

Biological Process

GO:0006184	GTP catabolic process
GO:0006886	intracellular protein transport
GO:0007030	Golgi organization
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007264	small GTPase mediated signal transduction
GO:0009404	toxin metabolic process
GO:0015031	protein transport
GO:0031584	activation of phospholipase D activity
GO:0034067	protein localization to Golgi apparatus
GO:0042147	retrograde transport, endosome to Golgi
GO:0048193	Golgi vesicle transport

Cellular Component

GO:0000139	Golgi membrane
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005802	trans-Golgi network
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000120805

View Gene Order

ENSBTAG00000011883

Not yet available

Cross-References

SwissProt

TrEMBL

E9Q006

UniProt Splice Variant

Entrez Gene

104303

UniGene

Mm.291247 Mm.358897 Mm.412622

RefSeq

NM_025859 XM_006513023

OMIM

CCDS

CCDS36025

HPRD

IMGT

MGI ID

MGI:99436

MGI Symbol

Arl1

EMBL

AC164567

GenPept

RNA Seq Atlas

104303