Homo sapiens Gene: ARL1
Summary
InnateDB Gene IDBG-53147.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARL1
Gene Name ADP-ribosylation factor-like 1
Synonyms ARFL1;
Species Homo sapiens
Ensembl Gene ENSG00000120805
Encoded Proteins
ADP-ribosylation factor-like 1
ADP-ribosylation factor-like 1
ADP-ribosylation factor-like 1
ADP-ribosylation factor-like 1
ADP-ribosylation factor-like 1
ADP-ribosylation factor-like 1
ADP-ribosylation factor-like 1
ADP-ribosylation factor-like 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the ARL (ADP-ribosylation factor-like) family of proteins, which are structurally related to ADP-ribosylation factors (ARFs). ARFs, described as activators of cholera toxin (CT) ADP-ribosyltransferase activity, regulate intracellular vesicular membrane trafficking, and stimulate a phospholipase D (PLD) isoform. Although, ARL proteins were initially thought not to activate CT or PLD, later work showed that they are weak stimulators of PLD and CT in a phospholipid dependent manner. [provided by RefSeq, Jul 2008]
The protein encoded by this gene belongs to the ARL (ADP-ribosylation factor-like) family of proteins, which are structurally related to ADP-ribosylation factors (ARFs). ARFs, described as activators of cholera toxin (CT) ADP-ribosyltransferase activity, regulate intracellular vesicular membrane trafficking, and stimulate a phospholipase D (PLD) isoform. Although, ARL proteins were initially thought not to activate CT or PLD, later work showed that they are weak stimulators of PLD and CT in a phospholipid dependent manner. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:101393120-101407820
Strand Reverse strand
Band q23.2
Transcripts
ENST00000261636 ENSP00000261636
ENST00000539055 ENSP00000439590
ENST00000536227 ENSP00000441808
ENST00000551688 ENSP00000447405
ENST00000550597
ENST00000551828 ENSP00000448850
ENST00000551671 ENSP00000448912
ENST00000551092 ENSP00000450162
ENST00000549283
ENST00000549302
ENST00000548070 ENSP00000450315
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 24 [view]
Protein-Protein 19 [view]
Protein-DNA 5 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0004871 signal transducer activity
GO:0005525 GTP binding
GO:0008047 enzyme activator activity
GO:0019001 guanyl nucleotide binding
GO:0019904 protein domain specific binding
GO:0031683 G-protein beta/gamma-subunit complex binding
GO:0046872 metal ion binding
Biological Process
GO:0006184 GTP catabolic process
GO:0006886 intracellular protein transport
GO:0007030 Golgi organization
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007264 small GTPase mediated signal transduction
GO:0009404 toxin metabolic process
GO:0015031 protein transport
GO:0031584 activation of phospholipase D activity
GO:0034067 protein localization to Golgi apparatus
GO:0042147 retrograde transport, endosome to Golgi
GO:0048193 Golgi vesicle transport
Cellular Component
GO:0000139 Golgi membrane
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005802 trans-Golgi network
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL B4DZG7 F8W1Z8
UniProt Splice Variant
Entrez Gene 400
UniGene Hs.372616 Hs.618679 Hs.707151
RefSeq NM_001301068 XM_005268869 NM_001177
HUGO HGNC:692
OMIM 603425
CCDS CCDS73510 CCDS44958
HPRD 04574
IMGT
EMBL AC063948 AK302911
GenPept BAG64079
RNA Seq Atlas 400