Mus musculus Gene: Rap1a
Summary
InnateDB Gene IDBG-183815.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rap1a
Gene Name RAS-related protein-1a
Synonyms AI848598; G-22K; Krev-1; Rap1;
Species Mus musculus
Ensembl Gene ENSMUSG00000068798
Encoded Proteins
RAS-related protein-1a
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000116473:
The product of this gene belongs to the family of RAS-related proteins. These proteins share approximately 50% amino acid identity with the classical RAS proteins and have numerous structural features in common. The most striking difference between RAP proteins and RAS proteins resides in their 61st amino acid: glutamine in RAS is replaced by threonine in RAP proteins. The product of this gene counteracts the mitogenic function of RAS because it can interact with RAS GAPs and RAF in a competitive manner. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]
This gene encodes a member of the Ras family of small GTPases. The encoded protein undergoes a change in conformational state and activity, depending on whether it is bound to GTP or GDP. This protein is activated by several types of guanine nucleotide exchange factors (GEFs), and inactivated by two groups of GTPase-activating proteins (GAPs). The activation status of the encoded protein is therefore affected by the balance of intracellular levels of GEFs and GAPs. The encoded protein regulates signaling pathways that affect cell proliferation and adhesion, and may play a role in tumor malignancy. Pseudogenes of this gene have been defined on chromosomes 14 and 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:105727267-105801330
Strand Reverse strand
Band F2.2
Transcripts
ENSMUST00000090678 ENSMUSP00000088174
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 55 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 11 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 55 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0008565 protein transporter activity
GO:0017016 Ras GTPase binding
GO:0017034 Rap guanyl-nucleotide exchange factor activity
GO:0032403 protein complex binding
Biological Process
GO:0006184 GTP catabolic process
GO:0006886 intracellular protein transport
GO:0006913 nucleocytoplasmic transport
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0010976 positive regulation of neuron projection development
GO:0015031 protein transport
GO:0032486 Rap protein signal transduction
GO:0032854 positive regulation of Rap GTPase activity
GO:0038180 nerve growth factor signaling pathway
GO:0045860 positive regulation of protein kinase activity
GO:0061028 establishment of endothelial barrier
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071320 cellular response to cAMP
GO:1901888 regulation of cell junction assembly
GO:1990090 cellular response to nerve growth factor stimulus
GO:2000301 negative regulation of synaptic vesicle exocytosis
GO:2001214 positive regulation of vasculogenesis
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005769 early endosome
GO:0005770 late endosome
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0030054 cell junction
GO:0032045 guanyl-nucleotide exchange factor complex
GO:0043005 neuron projection
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Hemostasis pathway
Integration of energy metabolism pathway
Metabolism pathway
Immune System pathway
Platelet activation, signaling and aggregation pathway
Regulation of insulin secretion pathway
Frs2-mediated activation pathway
Rap1 signalling pathway
Signalling to ERKs pathway
GRB2:SOS provides linkage to MAPK signaling for Integrins pathway
Signalling by NGF pathway
Adaptive Immune System pathway
p130Cas linkage to MAPK signaling for integrins pathway
NGF signalling via TRKA from the plasma membrane pathway
ARMS-mediated activation pathway
Signal Transduction pathway
Prolonged ERK activation events pathway
Integrin alphaIIb beta3 signaling pathway
Platelet Aggregation (Plug Formation) pathway
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion pathway
KEGG
MAPK signaling pathway pathway
Chemokine signaling pathway pathway
Focal adhesion pathway
Leukocyte transendothelial migration pathway
Long-term potentiation pathway
Neurotrophin signaling pathway pathway
Pancreatic secretion pathway
Renal cell carcinoma pathway
INOH
GPCR signaling pathway
Integrin signaling pathway pathway
GPCR Adenosine A2A receptor signaling pathway pathway
HGF signaling pathway pathway
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
EGFR1 pathway
TCR pathway
REACTOME
Integration of energy metabolism pathway
Rap1 signalling pathway
Signalling by NGF pathway
Platelet activation, signaling and aggregation pathway
Frs2-mediated activation pathway
Signal Transduction pathway
Integrin alphaIIb beta3 signaling pathway
Adaptive Immune System pathway
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion pathway
Immune System pathway
Signalling to ERKs pathway
NGF signalling via TRKA from the plasma membrane pathway
Platelet Aggregation (Plug Formation) pathway
GRB2:SOS provides linkage to MAPK signaling for Integrins pathway
ARMS-mediated activation pathway
p130Cas linkage to MAPK signaling for integrins pathway
Prolonged ERK activation events pathway
Regulation of insulin secretion pathway
Metabolism pathway
Hemostasis pathway
ARMS-mediated activation pathway
Signalling to ERKs pathway
Regulation of insulin secretion pathway
Prolonged ERK activation events pathway
Hemostasis pathway
Immune System pathway
Integration of energy metabolism pathway
Platelet activation, signaling and aggregation pathway
Platelet Aggregation (Plug Formation) pathway
Signal Transduction pathway
p130Cas linkage to MAPK signaling for integrins pathway
GRB2:SOS provides linkage to MAPK signaling for Integrins pathway
Integrin alphaIIb beta3 signaling pathway
NGF signalling via TRKA from the plasma membrane pathway
Metabolism pathway
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion pathway
Signalling by NGF pathway
Adaptive Immune System pathway
Rap1 signalling pathway
Frs2-mediated activation pathway
KEGG
MAPK signaling pathway pathway
Chemokine signaling pathway pathway
Focal adhesion pathway
Leukocyte transendothelial migration pathway
Long-term potentiation pathway
Neurotrophin signaling pathway pathway
Pancreatic secretion pathway
Renal cell carcinoma pathway
INOH
GPCR signaling pathway
Integrin signaling pathway pathway
GPCR Adenosine A2A receptor signaling pathway pathway
HGF signaling pathway pathway
PID BIOCARTA
PID NCI
TCR signaling in na´ve CD8+ T cells
Class I PI3K signaling events
Reelin signaling pathway
TCR signaling in na´ve CD4+ T cells
EPO signaling pathway
Signaling events regulated by Ret tyrosine kinase
Cross-References
SwissProt P62835
TrEMBL
UniProt Splice Variant
Entrez Gene 109905
UniGene Mm.365961 Mm.396701 Mm.458171
RefSeq NM_145541 XM_006500907
OMIM
CCDS CCDS17711
HPRD
IMGT
MGI ID MGI:97852
MGI Symbol Rap1a
EMBL BC051419 BC083128
GenPept AAH51419 AAH83128
RNA Seq Atlas 109905