Mus musculus Gene: Nfyc
Summary
InnateDB Gene IDBG-183886.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nfyc
Gene Name nuclear transcription factor-Y gamma
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000032897
Encoded Proteins
nuclear transcription factor-Y gamma
nuclear transcription factor-Y gamma
nuclear transcription factor-Y gamma
nuclear transcription factor-Y gamma
nuclear transcription factor-Y gamma
nuclear transcription factor-Y gamma
nuclear transcription factor-Y gamma
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000066136:
This gene encodes one subunit of a trimeric complex forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoters of a variety of genes. The encoded protein, subunit C, forms a tight dimer with the B subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:120757438-120831572
Strand Reverse strand
Band D2.2
Transcripts
ENSMUST00000043429 ENSMUSP00000047441
ENSMUST00000097906 ENSMUSP00000095516
ENSMUST00000118902 ENSMUSP00000112610
ENSMUST00000120779 ENSMUSP00000112810
ENSMUST00000127030
ENSMUST00000145029
ENSMUST00000148081
ENSMUST00000134979 ENSMUSP00000114640
ENSMUST00000136236 ENSMUSP00000117646
ENSMUST00000145658 ENSMUSP00000114591
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 39 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 1 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 39 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription factor complex
GO:0016602 CCAAT-binding factor complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
ATF6-alpha activates chaperone genes pathway
Fatty acid, triacylglycerol, and ketone body metabolism pathway
Activation of gene expression by SREBF (SREBP) pathway
Regulation of cholesterol biosynthesis by SREBP (SREBF) pathway
Unfolded Protein Response (UPR) pathway
Metabolism pathway
Metabolism of proteins pathway
Metabolism of lipids and lipoproteins pathway
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
PERK regulates gene expression pathway
ATF6-alpha activates chaperones pathway
PPARA activates gene expression pathway
ATF4 activates genes pathway
KEGG
Antigen processing and presentation pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
TGF_beta_Receptor pathway
REACTOME
Unfolded Protein Response (UPR) pathway
ATF4 activates genes pathway
Activation of gene expression by SREBF (SREBP) pathway
Metabolism of lipids and lipoproteins pathway
PPARA activates gene expression pathway
Metabolism of proteins pathway
PERK regulates gene expression pathway
ATF6-alpha activates chaperone genes pathway
Regulation of cholesterol biosynthesis by SREBP (SREBF) pathway
Fatty acid, triacylglycerol, and ketone body metabolism pathway
Metabolism pathway
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
ATF6-alpha activates chaperones pathway
PERK regulates gene expression pathway
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
ATF4 activates genes pathway
ATF6-alpha activates chaperone genes pathway
Metabolism of proteins pathway
Metabolism of lipids and lipoproteins pathway
Activation of gene expression by SREBF (SREBP) pathway
Metabolism pathway
PPARA activates gene expression pathway
Unfolded Protein Response (UPR) pathway
Regulation of cholesterol biosynthesis by SREBP (SREBF) pathway
Fatty acid, triacylglycerol, and ketone body metabolism pathway
ATF6-alpha activates chaperones pathway
KEGG
Antigen processing and presentation pathway
INOH
PID BIOCARTA
Overview of telomerase rna component gene hterc transcriptional regulation [Biocarta view]
PID NCI
Direct p53 effectors
Validated targets of C-MYC transcriptional repression
Cross-References
SwissProt
TrEMBL A2A764
UniProt Splice Variant
Entrez Gene 18046
UniGene Mm.435590
RefSeq NM_001048168 NM_008692 XM_006502846 XM_006502847 XM_006502848 XM_006502853
OMIM
CCDS CCDS18594
HPRD
IMGT
MGI ID MGI:107901
MGI Symbol Nfyc
EMBL AL606904 AL606924
GenPept
RNA Seq Atlas 18046