Homo sapiens Gene: NFYC
Summary
InnateDB Gene IDBG-96999.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NFYC
Gene Name nuclear transcription factor Y, gamma
Synonyms CBF-C; CBFC; H1TF2A; HAP5; HSM; NF-YC;
Species Homo sapiens
Ensembl Gene ENSG00000066136
Encoded Proteins
nuclear transcription factor Y, gamma
nuclear transcription factor Y, gamma
nuclear transcription factor Y, gamma
nuclear transcription factor Y, gamma
nuclear transcription factor Y, gamma
nuclear transcription factor Y, gamma
nuclear transcription factor Y, gamma
nuclear transcription factor Y, gamma
nuclear transcription factor Y, gamma
nuclear transcription factor Y, gamma
nuclear transcription factor Y, gamma
nuclear transcription factor Y, gamma
nuclear transcription factor Y, gamma
nuclear transcription factor Y, gamma
nuclear transcription factor Y, gamma
nuclear transcription factor Y, gamma
nuclear transcription factor Y, gamma
nuclear transcription factor Y, gamma
nuclear transcription factor Y, gamma
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes one subunit of a trimeric complex forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoters of a variety of genes. The encoded protein, subunit C, forms a tight dimer with the B subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:40691570-40771603
Strand Forward strand
Band p34.2
Transcripts
ENST00000372669 ENSP00000361754
ENST00000372654 ENSP00000361738
ENST00000372653 ENSP00000361737
ENST00000372652 ENSP00000361736
ENST00000372651 ENSP00000361734
ENST00000308733 ENSP00000312617
ENST00000425457 ENSP00000396620
ENST00000447388 ENSP00000404427
ENST00000456393 ENSP00000408867
ENST00000427410 ENSP00000408315
ENST00000424419
ENST00000453631 ENSP00000397647
ENST00000416859 ENSP00000409219
ENST00000440226 ENSP00000414299
ENST00000414185 ENSP00000416403
ENST00000467203
ENST00000483091
ENST00000488635
ENST00000496608
ENST00000534399 ENSP00000433820
ENST00000531464 ENSP00000434404
ENST00000525290 ENSP00000436710
ENST00000530965 ENSP00000433413
ENST00000525349
ENST00000620728 ENSP00000480994
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 43 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 43 [view]
Protein-Protein 39 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003713 transcription coactivator activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006457 protein folding
GO:0044255 cellular lipid metabolic process
GO:0044281 small molecule metabolic process
GO:0045893 positive regulation of transcription, DNA-templated
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0016602 CCAAT-binding factor complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
TGF_beta_Receptor pathway
REACTOME
Unfolded Protein Response (UPR) pathway
ATF4 activates genes pathway
Activation of gene expression by SREBF (SREBP) pathway
Metabolism of lipids and lipoproteins pathway
PPARA activates gene expression pathway
Metabolism of proteins pathway
PERK regulates gene expression pathway
ATF6-alpha activates chaperone genes pathway
Regulation of cholesterol biosynthesis by SREBP (SREBF) pathway
Fatty acid, triacylglycerol, and ketone body metabolism pathway
Metabolism pathway
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
ATF6-alpha activates chaperones pathway
KEGG
Antigen processing and presentation pathway
INOH
PID BIOCARTA
Overview of telomerase rna component gene hterc transcriptional regulation [Biocarta view]
PID NCI
Direct p53 effectors
Validated targets of C-MYC transcriptional repression
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.626316
RefSeq NM_001142587 NM_001142588 NM_001142589 NM_001142590 NM_014223 XM_005270891 XM_005270893 XM_005270894 XM_005270895 XM_005270896 XM_006710656 XM_006710657 XM_006710659 XM_006710660 XM_006710661 XM_006710662
HUGO
OMIM
CCDS CCDS44120 CCDS44121 CCDS44122 CCDS44123 CCDS455
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas