InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: NFYC

Summary

InnateDB Gene

IDBG-96999.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NFYC

Gene Name

nuclear transcription factor Y, gamma

Synonyms

CBF-C; CBFC; H1TF2A; HAP5; HSM; NF-YC

Species

Homo sapiens

Ensembl Gene

ENSG00000066136

Encoded Proteins

IDBP-97001

nuclear transcription factor Y, gamma

IDBP-97011

nuclear transcription factor Y, gamma

IDBP-97013

nuclear transcription factor Y, gamma

IDBP-97015

nuclear transcription factor Y, gamma

IDBP-97017

nuclear transcription factor Y, gamma

IDBP-97019

nuclear transcription factor Y, gamma

IDBP-381428

nuclear transcription factor Y, gamma

IDBP-381429

nuclear transcription factor Y, gamma

IDBP-381431

nuclear transcription factor Y, gamma

IDBP-381435

nuclear transcription factor Y, gamma

IDBP-381448

nuclear transcription factor Y, gamma

IDBP-381454

nuclear transcription factor Y, gamma

IDBP-381456

nuclear transcription factor Y, gamma

IDBP-381457

nuclear transcription factor Y, gamma

IDBP-598394

nuclear transcription factor Y, gamma

IDBP-599788

nuclear transcription factor Y, gamma

IDBP-600697

nuclear transcription factor Y, gamma

IDBP-590749

nuclear transcription factor Y, gamma

IDBP-813040

nuclear transcription factor Y, gamma

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes one subunit of a trimeric complex forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoters of a variety of genes. The encoded protein, subunit C, forms a tight dimer with the B subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:40691570-40771603

Strand

Forward strand

Band

p34.2

Transcripts

ENST00000372669	ENSP00000361754
ENST00000372654	ENSP00000361738
ENST00000372653	ENSP00000361737
ENST00000372652	ENSP00000361736
ENST00000372651	ENSP00000361734
ENST00000308733	ENSP00000312617
ENST00000425457	ENSP00000396620
ENST00000447388	ENSP00000404427
ENST00000456393	ENSP00000408867
ENST00000427410	ENSP00000408315
ENST00000424419
ENST00000453631	ENSP00000397647
ENST00000416859	ENSP00000409219
ENST00000440226	ENSP00000414299
ENST00000414185	ENSP00000416403
ENST00000467203
ENST00000483091
ENST00000488635
ENST00000496608
ENST00000534399	ENSP00000433820
ENST00000531464	ENSP00000434404
ENST00000525290	ENSP00000436710
ENST00000530965	ENSP00000433413
ENST00000525349
ENST00000620728	ENSP00000480994

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 43 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	43 [view]
Protein-Protein	39 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003713	transcription coactivator activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006457	protein folding
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0045893	positive regulation of transcription, DNA-templated

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0016602	CCAAT-binding factor complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000032897

View Gene Order

ENSBTAG00000021943

Not yet available

Pathways

NETPATH

NetPath_7

TGF_beta_Receptor pathway

REACTOME

REACT_18355

ATF4 activates genes pathway

REACT_18277

PERK regulates gene expression pathway

REACT_18423

ATF6-alpha activates chaperone genes pathway

REACT_18348

ATF6-alpha activates chaperones pathway

REACT_116145

PPARA activates gene expression pathway

REACT_19241

Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway

REACT_147904

Activation of gene expression by SREBF (SREBP) pathway

REACT_147797

Regulation of cholesterol biosynthesis by SREBP (SREBF) pathway

REACT_22279

Fatty acid, triacylglycerol, and ketone body metabolism pathway

REACT_18356

Unfolded Protein Response (UPR) pathway

REACT_22258

Metabolism of lipids and lipoproteins pathway

REACT_17015

Metabolism of proteins pathway

REACT_111217

Metabolism pathway

KEGG

hsa04612

Antigen processing and presentation pathway

INOH

PID NCI

p53downstreampathway

Direct p53 effectors

myc_represspathway

Validated targets of C-MYC transcriptional repression

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.626316

RefSeq

NM_001142587 NM_001142588 NM_001142589 NM_001142590 NM_014223 XM_005270891 XM_005270893 XM_005270894 XM_005270895 XM_005270896 XM_006710656 XM_006710657 XM_006710659 XM_006710660 XM_006710661 XM_006710662

HUGO

OMIM

CCDS

CCDS44120 CCDS44121 CCDS44122 CCDS44123 CCDS455

HPRD

IMGT

EMBL

GenPept

RNA Seq Atlas