Version 5.4
Homo sapiens Gene: SERPINA3
Summary
InnateDB Gene IDBG-18406.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SERPINA3
Gene Name serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000196136
Encoded Proteins
IDBP-244344
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
IDBP-244346
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
IDBP-601881
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
IDBP-596932
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
IDBP-588615
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
IDBP-588896
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
IDBP-603032
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
IDBP-810149
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a plasma protease inhibitor and member of the serine protease inhibitor class. Polymorphisms in this protein appear to be tissue specific and influence protease targeting. Variations in this protein's sequence have been implicated in Alzheimer's disease, and deficiency of this protein has been associated with liver disease. Mutations have been identified in patients with Parkinson disease and chronic obstructive pulmonary disease. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:94612384-94624055
Strand Forward strand
Band q32.13
Transcripts
ENST00000393080 ENSP00000376795
ENST00000393078 ENSP00000376793
ENST00000485588
ENST00000467132 ENSP00000450540
ENST00000482740 ENSP00000451119
ENST00000553947 ENSP00000452367
ENST00000555820 ENSP00000452246
ENST00000556388
ENST00000556968 ENSP00000452476
ENST00000621603 ENSP00000481617
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
Experimentally validated
Total 16 [view]
Protein-Protein 16 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0005515 protein binding
Biological Process
GO:0006953 acute-phase response
GO:0006954 inflammatory response
GO:0010951 negative regulation of endopeptidase activity
GO:0019216 regulation of lipid metabolic process
GO:0030162 regulation of proteolysis
GO:0030277 maintenance of gastrointestinal epithelium
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005622 intracellular
GO:0005634 nucleus
GO:0070062 extracellular vesicular exosome
GO:0072562 blood microparticle
Orthologs
No orthologs found for this gene
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.534293 Hs.731935
RefSeq NM_001085
HUGO
OMIM
CCDS CCDS32150
HPRD 00120
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca