Version 5.4
Mus musculus Gene: Tfpi
Summary
InnateDB Gene IDBG-184676.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tfpi
Gene Name tissue factor pathway inhibitor
Synonyms A630013F22Rik; AW552122; EPI; LACI
Species Mus musculus
Ensembl Gene ENSMUSG00000027082
Encoded Proteins
IDBP-184678
tissue factor pathway inhibitor
IDBP-184680
tissue factor pathway inhibitor
IDBP-257514
tissue factor pathway inhibitor
IDBP-257516
tissue factor pathway inhibitor
IDBP-257518
tissue factor pathway inhibitor
IDBP-257520
tissue factor pathway inhibitor
IDBP-257524
tissue factor pathway inhibitor
IDBP-538103
tissue factor pathway inhibitor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000003436:
This gene encodes a protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation. The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot. The product of this gene inhibits the activated factor X and VIIa-TF proteases in an autoregulatory loop. The encoded protein is glycosylated and predominantly found in the vascular endothelium and plasma in both free forms and complexed with plasma lipoproteins. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been confirmed. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:84432855-84476775
Strand Reverse strand
Band D
Transcripts
ENSMUST00000028487 ENSMUSP00000028487
ENSMUST00000090732 ENSMUSP00000088235
ENSMUST00000111722 ENSMUSP00000107351
ENSMUST00000111718 ENSMUSP00000107347
ENSMUST00000111717 ENSMUSP00000107346
ENSMUST00000111714 ENSMUSP00000107343
ENSMUST00000111711 ENSMUSP00000107340
ENSMUST00000125677
ENSMUST00000150261 ENSMUSP00000122776
ENSMUST00000144775
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0030414 peptidase inhibitor activity
Biological Process
GO:0007596 blood coagulation
GO:0010466 negative regulation of peptidase activity
GO:0010951 negative regulation of endopeptidase activity
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000003436
View Gene Order
Pathways
NETPATH
REACTOME
REACT_224553
Hemostasis pathway
REACT_240293
Extrinsic Pathway pathway
REACT_235097
Formation of Fibrin Clot (Clotting Cascade) pathway
KEGG
mmu04610
Complement and coagulation cascades pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_1573
Extrinsic Pathway pathway
REACT_2051
Formation of Fibrin Clot (Clotting Cascade) pathway
REACT_604
Hemostasis pathway
KEGG
hsa04610
Complement and coagulation cascades pathway
INOH
PID NCI
syndecan_4_pathway
Syndecan-4-mediated signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.124316 Mm.395995 Mm.487161
RefSeq NM_001177319 NM_001177320 NM_011576 XM_006499145 XM_006499147 XM_006499148
OMIM
CCDS CCDS16185 CCDS50620
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca