Version 5.4
| Mus musculus Protein: Tfpi | |||||||
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| Summary | |||||||
| InnateDB Protein | IDBP-184678.6 | ||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||
| Gene Symbol | Tfpi | ||||||
| Protein Name | tissue factor pathway inhibitor | ||||||
| Synonyms | A630013F22Rik; AW552122; EPI; LACI; | ||||||
| Species | Mus musculus | ||||||
| Ensembl Protein | ENSMUSP00000028487 | ||||||
| InnateDB Gene | IDBG-184676 (Tfpi) | ||||||
| Protein Structure |
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| UniProt Annotation | |||||||
| Function | Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma (By similarity). {ECO:0000250}. | ||||||
| Subcellular Localization | Secreted. | ||||||
| Disease Associations | |||||||
| Tissue Specificity | Isoform alpha is expressed in heart and spleen; isoform beta in heart and lung. | ||||||
| Comments | |||||||
| Interactions | |||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||
| PDB ID | MGI:1095418 | ||||||
| InterPro |
IPR002223
Proteinase inhibitor I2, Kunitz metazoa IPR008296 Proteinase inhibitor I2, tissue factor pathway inhibitor |
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| PFAM |
PF00014
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| PRINTS |
PR00759
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| PIRSF |
PIRSF001620
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| SMART |
SM00131
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| TIGRFAMs | |||||||
| Post-translational Modifications | |||||||
| Modification | |||||||
| Cross-References | |||||||
| SwissProt | O54819 | ||||||
| PhosphoSite | PhosphoSite-O54819 | ||||||
| TrEMBL | |||||||
| UniProt Splice Variant | |||||||
| Entrez Gene | 21788 | ||||||
| UniGene | Mm.487161 | ||||||
| RefSeq | NP_035706 | ||||||
| MGI ID | |||||||
| MGI Symbol | Tfpi | ||||||
| OMIM | |||||||
| CCDS | CCDS16185 | ||||||
| HPRD | |||||||
| IMGT | |||||||
| EMBL | AF004833 AF016313 AK028356 | ||||||
| GenPept | AAC40035 AAD01586 BAC25901 | ||||||