InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Fbxl3

Summary

InnateDB Gene

IDBG-184717.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fbxl3

Gene Name

F-box and leucine-rich repeat protein 3

Synonyms

AU041772; AW212966; FBK; Fbl3a; Fbxl3a; Ovtm; Play68

Species

Mus musculus

Ensembl Gene

ENSMUSG00000022124

Encoded Proteins

IDBP-184719

F-box and leucine-rich repeat protein 3

IDBP-538736

F-box and leucine-rich repeat protein 3

IDBP-539297

F-box and leucine-rich repeat protein 3

IDBP-531583

F-box and leucine-rich repeat protein 3

IDBP-541878

F-box and leucine-rich repeat protein 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000005812:
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains several tandem leucine-rich repeats and is localized in the nucleus. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:103080239-103099566

Strand

Reverse strand

Band

E2.3

Transcripts

ENSMUST00000022720	ENSMUSP00000022720
ENSMUST00000145693	ENSMUSP00000116044
ENSMUST00000132004	ENSMUSP00000115843
ENSMUST00000127113
ENSMUST00000144141	ENSMUSP00000120691
ENSMUST00000123043	ENSMUSP00000117701

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding

Biological Process

GO:0016567	protein ubiquitination
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0031648	protein destabilization
GO:0042752	regulation of circadian rhythm
GO:0043153	entrainment of circadian clock by photoperiod
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0048511	rhythmic process