InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: FBXL3

Summary

InnateDB Gene

IDBG-39434.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FBXL3

Gene Name

F-box and leucine-rich repeat protein 3

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000005812

Encoded Proteins

IDBP-39436

F-box and leucine-rich repeat protein 3

IDBP-370928

F-box and leucine-rich repeat protein 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains several tandem leucine-rich repeats and is localized in the nucleus. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:76992598-77027195

Strand

Reverse strand

Band

q22.3

Transcripts

ENST00000355619	ENSP00000347834
ENST00000417323	ENSP00000412183
ENST00000485797
ENST00000477982
ENST00000470210
ENST00000472949

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	23 [view]
Protein-Protein	23 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding

Biological Process

GO:0016567	protein ubiquitination
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0031648	protein destabilization
GO:0042752	regulation of circadian rhythm
GO:0043153	entrainment of circadian clock by photoperiod
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0048511	rhythmic process

Cellular Component

GO:0000151	ubiquitin ligase complex
GO:0005634	nucleus
GO:0005829	cytosol
GO:0019005	SCF ubiquitin ligase complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000022124

View Gene Order

ENSBTAG00000018848

Not yet available

Pathways

NETPATH

REACTOME

REACT_16907

Association of TriC/CCT with target proteins during biosynthesis pathway

REACT_24941

Circadian Clock pathway

REACT_16952

Protein folding pathway

REACT_17004

Chaperonin-mediated protein folding pathway

REACT_17015

Metabolism of proteins pathway

KEGG

hsa04710

Circadian rhythm pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.508284 Hs.713348

RefSeq

NM_012158 XM_005266336

HUGO

OMIM

CCDS

CCDS9457

HPRD

05737

IMGT

EMBL

GenPept

RNA Seq Atlas