Mus musculus Gene: Kcna3
Summary
InnateDB Gene IDBG-184980.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Kcna3
Gene Name potassium voltage-gated channel, shaker-related subfamily, member 3
Synonyms Kca1-3; Kv1.3; Mk-3;
Species Mus musculus
Ensembl Gene ENSMUSG00000047959
Encoded Proteins
potassium voltage-gated channel, shaker-related subfamily, member 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000177272:
Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. It plays an essential role in T-cell proliferation and activation. This gene appears to be intronless and it is clustered together with KCNA2 and KCNA10 genes on chromosome 1. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:107036162-107038129
Strand Forward strand
Band F2.3
Transcripts
ENSMUST00000052718 ENSMUSP00000050680
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005216 ion channel activity
GO:0005251 delayed rectifier potassium channel activity
GO:0005515 protein binding
GO:0015271 outward rectifier potassium channel activity
Biological Process
GO:0006811 ion transport
GO:0034765 regulation of ion transmembrane transport
GO:0051260 protein homooligomerization
GO:0055085 transmembrane transport
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0008076 voltage-gated potassium channel complex
GO:0016020 membrane
GO:0045121 membrane raft
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Potassium Channels pathway
Neuronal System pathway
Voltage gated Potassium channels pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Neuronal System pathway
Voltage gated Potassium channels pathway
Potassium Channels pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P16390
TrEMBL
UniProt Splice Variant
Entrez Gene 16491
UniGene Mm.30640
RefSeq NM_008418
OMIM
CCDS CCDS17730
HPRD
IMGT
MGI ID MGI:96660
MGI Symbol Kcna3
EMBL BC132349 BC137667 CH466607 M30441
GenPept AAA39716 AAI32350 AAI37668 EDL01888
RNA Seq Atlas 16491