InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Kcna3

Summary

InnateDB Gene

IDBG-184980.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Kcna3

Gene Name

potassium voltage-gated channel, shaker-related subfamily, member 3

Synonyms

Kca1-3; Kv1.3; Mk-3

Species

Mus musculus

Ensembl Gene

ENSMUSG00000047959

Encoded Proteins

IDBP-184982

potassium voltage-gated channel, shaker-related subfamily, member 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000177272:
Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. It plays an essential role in T-cell proliferation and activation. This gene appears to be intronless and it is clustered together with KCNA2 and KCNA10 genes on chromosome 1. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:107036162-107038129

Strand

Forward strand

Band

F2.3

Transcripts

ENSMUST00000052718

ENSMUSP00000050680

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005251	delayed rectifier potassium channel activity
GO:0005515	protein binding
GO:0015271	outward rectifier potassium channel activity

Biological Process

GO:0006811	ion transport
GO:0034765	regulation of ion transmembrane transport
GO:0051260	protein homooligomerization
GO:0055085	transmembrane transport
GO:0071805	potassium ion transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0008076	voltage-gated potassium channel complex
GO:0016020	membrane
GO:0045121	membrane raft

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000177272

View Gene Order

ENSBTAG00000047879

Not yet available

Pathways

NETPATH

REACTOME

REACT_202800

Potassium Channels pathway

REACT_259290

Neuronal System pathway

REACT_199077

Voltage gated Potassium channels pathway

KEGG

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_75770

Voltage gated Potassium channels pathway

REACT_13685

Neuronal System pathway

REACT_75908

Potassium Channels pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

P16390

TrEMBL

UniProt Splice Variant

Entrez Gene

16491

UniGene

Mm.30640

RefSeq

NM_008418

OMIM

CCDS

CCDS17730

HPRD

IMGT

MGI ID

MGI:96660

MGI Symbol

Kcna3

EMBL

BC132349 BC137667 CH466607 M30441

GenPept

AAA39716 AAI32350 AAI37668 EDL01888

RNA Seq Atlas

16491