Mus musculus Gene: Slc4a8
Summary
InnateDB Gene IDBG-185143.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Slc4a8
Gene Name solute carrier family 4 (anion exchanger), member 8
Synonyms AW493845; C230026C11; kNBC-3; NDCBE;
Species Mus musculus
Ensembl Gene ENSMUSG00000023032
Encoded Proteins
solute carrier family 4 (anion exchanger), member 8
solute carrier family 4 (anion exchanger), member 8
solute carrier family 4 (anion exchanger), member 8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000050438:
The protein encoded by this gene is a membrane protein that functions to transport sodium and bicarbonate ions across the cell membrane. The encoded protein is important for pH regulation in neurons. The activity of this protein can be inhibited by 4,4'-Di-isothiocyanatostilbene-2,2'-disulfonic acid (DIDS). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
The protein encoded by this gene is a membrane protein that functions to transport sodium and bicarbonate ions across the cell membrane. The encoded protein is important for pH regulation in neurons. The activity of this protein can be inhibited by 4,4\'-Di-isothiocyanatostilbene-2,2\'-disulfonic acid (DIDS). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:100761747-100823968
Strand Forward strand
Band F1
Transcripts
ENSMUST00000023776 ENSMUSP00000023776
ENSMUST00000161564 ENSMUSP00000123864
ENSMUST00000160256
ENSMUST00000162049 ENSMUSP00000125090
ENSMUST00000162805
ENSMUST00000162483
ENSMUST00000162744
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0005452 inorganic anion exchanger activity
GO:0008509 anion transmembrane transporter activity
Biological Process
GO:0006810 transport
GO:0006814 sodium ion transport
GO:0006820 anion transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0032809 neuronal cell body membrane
GO:0043005 neuron projection
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
SLC-mediated transmembrane transport pathway
Transport of inorganic cations/anions and amino acids/oligopeptides pathway
Bicarbonate transporters pathway
Transmembrane transport of small molecules pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Transmembrane transport of small molecules pathway
Bicarbonate transporters pathway
Transport of inorganic cations/anions and amino acids/oligopeptides pathway
SLC-mediated transmembrane transport pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.209856 Mm.408499
RefSeq NM_021530 XM_006521225 XM_006521226
OMIM
CCDS CCDS37214
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas