InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Slc4a8

Summary

InnateDB Protein

IDBP-185145.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slc4a8

Protein Name

solute carrier family 4 (anion exchanger), member 8

Synonyms

AW493845; C230026C11; kNBC-3; NDCBE;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000023776

InnateDB Gene

IDBG-185143 (Slc4a8)

Protein Structure

UniProt Annotation

Function

Mediates electroneutral sodium- and carbonate-dependent chloride-HCO3(-) exchange with a Na(+):HCO3(-) stoichiometry of 2:1. Plays a major role in pH regulation in neurons. May be involved in cell pH regulation by transporting HCO3(-) from blood to cell. Enhanced expression in severe acid stress could be important for cell survival by mediating the influx of HCO3(-) into the cells. Also mediates lithium-dependent HCO3(-) cotransport. May be regulated by osmolarity. {ECO:0000269PubMed:11260402}.

Subcellular Localization

Membrane {ECO:0000269PubMed:11260402}; Multi-pass membrane protein {ECO:0000269PubMed:11260402}.

Disease Associations

Tissue Specificity

Highly expressed in brain with lower levels in lung, kidney and heart. In the kidney, there is high expression in the inner medulla, localized to the inner medullary collecting duct. In the brain, there seems to be three transcripts each having a different expression pattern. The smaller 3kb transcript has highest expression levels in the thalamus and the largest 9.5kb transcript has highest levels in the substantia nigra. The middle transcript of 4.4kb, which is also the main transcript in kidney, is highly expressed in thalamus. Hence, the highest levels are observed in the thalamus, amygdala and caudate nucleus and very low expression was seen in the corpus callosum. {ECO:0000269PubMed:11260402}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005452	inorganic anion exchanger activity
GO:0008509	anion transmembrane transporter activity

Biological Process

GO:0006810	transport
GO:0006814	sodium ion transport
GO:0006820	anion transport
GO:0055085	transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0032809	neuronal cell body membrane
GO:0043005	neuron projection

Protein Structure and Domains

PDB ID

MGI:1928745

InterPro

IPR003020 Bicarbonate transporter, eukaryotic
IPR003024 Sodium bicarbonate cotransporter
IPR011531 Bicarbonate transporter, C-terminal
IPR013769 Band 3 cytoplasmic domain
IPR016152 Phosphotransferase/anion transporter

PFAM

PF00955
PF07565

PRINTS

PR01231
PR01232

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8JZR6