InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Serping1

Summary

InnateDB Gene

IDBG-185264.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Serping1

Gene Name

serine (or cysteine) peptidase inhibitor, clade G, member 1

Synonyms

C1INH; C1nh

Species

Mus musculus

Ensembl Gene

ENSMUSG00000023224

Encoded Proteins

IDBP-185266

serine (or cysteine) peptidase inhibitor, clade G, member 1

IDBP-257697

serine (or cysteine) peptidase inhibitor, clade G, member 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 17709141

[Homo sapiens] A likely regulator of MASP2

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000149131:
This gene encodes a highly glycosylated plasma protein involved in the regulation of the complement cascade. Its protein inhibits activated C1r and C1s of the first complement component and thus regulates complement activation. Deficiency of this protein is associated with hereditary angioneurotic oedema (HANE). Alternative splicing results in multiple transcript variants encoding the same isoform. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:84765387-84775444

Strand

Reverse strand

Band

Transcripts

ENSMUST00000023994	ENSMUSP00000023994
ENSMUST00000111641	ENSMUSP00000107268
ENSMUST00000131456

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004867	serine-type endopeptidase inhibitor activity
GO:0005515	protein binding

Biological Process

GO:0001869	negative regulation of complement activation, lectin pathway
GO:0006958	complement activation, classical pathway
GO:0007568	aging
GO:0007596	blood coagulation
GO:0010951	negative regulation of endopeptidase activity
GO:0030162	regulation of proteolysis
GO:0030193	regulation of blood coagulation
GO:0042730	fibrinolysis
GO:0045087	innate immune response