Version 5.4
Homo sapiens Gene: SERPING1
Summary
InnateDB Gene IDBG-46853.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SERPING1
Gene Name serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
Synonyms C1IN; C1INH; C1NH; HAE1; HAE2
Species Homo sapiens
Ensembl Gene ENSG00000149131
Encoded Proteins
IDBP-46855
serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
IDBP-46857
serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
IDBP-46859
serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
IDBP-46861
serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
IDBP-295591
serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
IDBP-295604
serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
IDBP-374326
serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
IDBP-583630
serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
IDBP-594535
serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
IDBP-589222
serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
IDBP-813685
serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 17709141
A likely regulator of MASP2
Entrez Gene
Summary This gene encodes a highly glycosylated plasma protein involved in the regulation of the complement cascade. Its protein inhibits activated C1r and C1s of the first complement component and thus regulates complement activation. Deficiency of this protein is associated with hereditary angioneurotic oedema (HANE). Alternative splicing results in multiple transcript variants encoding the same isoform. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:57597387-57614853
Strand Forward strand
Band q12.1
Transcripts
ENST00000278407 ENSP00000278407
ENST00000378324 ENSP00000367575
ENST00000378323 ENSP00000367574
ENST00000340687 ENSP00000341861
ENST00000403558 ENSP00000384420
ENST00000405496 ENSP00000384561
ENST00000457869 ENSP00000399746
ENST00000531797 ENSP00000432554
ENST00000531133 ENSP00000435431
ENST00000531605
ENST00000528996 ENSP00000431226
ENST00000530113
ENST00000619430 ENSP00000478572
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
Experimentally validated
Total 17 [view]
Protein-Protein 14 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0005515 protein binding
GO:0008233 peptidase activity
Biological Process
GO:0001869 negative regulation of complement activation, lectin pathway
GO:0002576 platelet degranulation
GO:0006508 proteolysis
GO:0006958 complement activation, classical pathway
GO:0007568 aging
GO:0007596 blood coagulation
GO:0007597 blood coagulation, intrinsic pathway
GO:0008015 blood circulation
GO:0010951 negative regulation of endopeptidase activity
GO:0030168 platelet activation
GO:0030193 regulation of blood coagulation
GO:0042730 fibrinolysis
GO:0045087 innate immune response (InnateDB)
GO:0045916 negative regulation of complement activation
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0031093 platelet alpha granule lumen
GO:0070062 extracellular vesicular exosome
GO:0072562 blood microparticle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000023224
View Gene Order
ENSBTAG00000016267
Not yet available
Pathways
NETPATH
REACTOME
REACT_326
Intrinsic Pathway pathway
REACT_318
Platelet degranulation pathway
REACT_1280
Response to elevated platelet cytosolic Ca2+ pathway
REACT_2051
Formation of Fibrin Clot (Clotting Cascade) pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_604
Hemostasis pathway
KEGG
hsa04610
Complement and coagulation cascades pathway
INOH
PID NCI
Cross-References
SwissProt P05155
TrEMBL B4E1F0 B4E1H2 B5MCB9 C9JZJ9 E9KL26 E9PGN7 E9PK97 H0YCA1 H9KV48
UniProt Splice Variant
Entrez Gene 710
UniGene Hs.384598 Hs.706637
RefSeq NM_000062 NM_001032295
HUGO HGNC:1228
OMIM 606860
CCDS CCDS7962
HPRD
IMGT
EMBL AB209826 AF435921 AK293054 AK303809 AK303840 AK312626 AP000662 AP002893 AY291075 AY904027 BC011171 BT006966 CH471076 GU727623 M13203 M13656 M13690 M14036 M30688 S76944 X07427 X07428 X07429 X07430 X07431 X07432 X07433 X07577 X54486
GenPept AAA35613 AAA51848 AAA51849 AAA53096 AAB33044 AAB59387 AAH11171 AAM21515 AAP35612 AAQ19269 AAW69393 ADU87625 BAD93063 BAF85743 BAG35512 BAG64762 BAG64784 CAA30314 CAA30469 CAA38358 EAW73764
RNA Seq Atlas 710

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca