Mus musculus Gene: M6pr
Summary
InnateDB Gene IDBG-185276.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol M6pr
Gene Name mannose-6-phosphate receptor, cation dependent
Synonyms CD-MPR; Mpr46;
Species Mus musculus
Ensembl Gene ENSMUSG00000007458
Encoded Proteins
mannose-6-phosphate receptor, cation dependent
mannose-6-phosphate receptor, cation dependent
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000003056:
This gene encodes a member of the P-type lectin family. P-type lectins play a critical role in lysosome function through the specific transport of mannose-6-phosphate-containing acid hydrolases from the Golgi complex to lysosomes. The encoded protein functions as a homodimer and requires divalent cations for ligand binding. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome X. [provided by RefSeq, May 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:122308720-122317680
Strand Forward strand
Band F1
Transcripts
ENSMUST00000007602 ENSMUSP00000007602
ENSMUST00000112610 ENSMUSP00000108229
ENSMUST00000123093
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005537 mannose binding
GO:0015578 mannose transmembrane transporter activity
Biological Process
GO:0006886 intracellular protein transport
GO:0015761 mannose transport
Cellular Component
GO:0005765 lysosomal membrane
GO:0005768 endosome
GO:0005770 late endosome
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Membrane Trafficking pathway
Lysosome Vesicle Biogenesis pathway
trans-Golgi Network Vesicle Budding pathway
Clathrin derived vesicle budding pathway
KEGG
Lysosome pathway
Phagosome pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
trans-Golgi Network Vesicle Budding pathway
Clathrin derived vesicle budding pathway
Lysosome Vesicle Biogenesis pathway
Membrane Trafficking pathway
KEGG
Lysosome pathway
Phagosome pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.249225 Mm.445722 Mm.471039
RefSeq NM_010749
OMIM
CCDS CCDS20493
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas