Version 5.4
Mus musculus Gene: M6pr
Summary
InnateDB Gene IDBG-185276.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol M6pr
Gene Name mannose-6-phosphate receptor, cation dependent
Synonyms CD-MPR; Mpr46
Species Mus musculus
Ensembl Gene ENSMUSG00000007458
Encoded Proteins
IDBP-185278
mannose-6-phosphate receptor, cation dependent
IDBP-255651
mannose-6-phosphate receptor, cation dependent
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000003056:
This gene encodes a member of the P-type lectin family. P-type lectins play a critical role in lysosome function through the specific transport of mannose-6-phosphate-containing acid hydrolases from the Golgi complex to lysosomes. The encoded protein functions as a homodimer and requires divalent cations for ligand binding. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome X. [provided by RefSeq, May 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:122308720-122317680
Strand Forward strand
Band F1
Transcripts
ENSMUST00000007602 ENSMUSP00000007602
ENSMUST00000112610 ENSMUSP00000108229
ENSMUST00000123093
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005537 mannose binding
GO:0015578 mannose transmembrane transporter activity
Biological Process
GO:0006886 intracellular protein transport
GO:0015761 mannose transport
Cellular Component
GO:0005765 lysosomal membrane
GO:0005768 endosome
GO:0005770 late endosome
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000003056
View Gene Order
ENSBTAG00000018207
Not yet available
Pathways
NETPATH
REACTOME
REACT_209837
Membrane Trafficking pathway
REACT_231722
Lysosome Vesicle Biogenesis pathway
REACT_243409
trans-Golgi Network Vesicle Budding pathway
REACT_234979
Clathrin derived vesicle budding pathway
KEGG
mmu04142
Lysosome pathway
mmu04145
Phagosome pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_19287
Lysosome Vesicle Biogenesis pathway
REACT_19187
Clathrin derived vesicle budding pathway
REACT_11235
trans-Golgi Network Vesicle Budding pathway
REACT_11123
Membrane Trafficking pathway
KEGG
hsa04142
Lysosome pathway
hsa04145
Phagosome pathway
INOH
PID NCI
Cross-References
SwissProt P24668
TrEMBL Q3UKQ5
UniProt Splice Variant
Entrez Gene 17113
UniGene Mm.249225 Mm.445722 Mm.471039
RefSeq NM_010749
OMIM
CCDS CCDS20493
HPRD
IMGT
MGI ID MGI:96904
MGI Symbol M6pr
EMBL AK133943 AK145913 AK151607 AK153302 BC027210 BC046956 BC080811 CH466523 M58585 M63286 X56831 X64068 X64070
GenPept AAA39482 AAA39735 AAH27210 AAH46956 AAH80811 BAE21941 BAE26746 BAE30546 BAE31884 CAA40162 CAA45423 CAA45426 EDK99677 EDK99678
RNA Seq Atlas 17113

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca