InnateDB Protein
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IDBP-185278.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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M6pr
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Protein Name
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mannose-6-phosphate receptor, cation dependent
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Synonyms
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CD-MPR; Mpr46;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000007602
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InnateDB Gene
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IDBG-185276 (M6pr)
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Protein Structure
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Function |
Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6- phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex.
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Subcellular Localization |
Lysosome membrane; Single-pass type I membrane protein.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Experimentally validated |
Total |
3
[view]
|
Protein-Protein |
3
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
14 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:96904
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InterPro |
IPR000296
Cation-dependent mannose-6-phosphate receptor
IPR009011
Mannose-6-phosphate receptor binding domain
IPR028927
Mannose-6-phosphate receptor
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PFAM |
PF02157
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PRINTS |
PR00715
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P24668
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PhosphoSite |
PhosphoSite-P24668
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TrEMBL |
Q3UKQ5
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UniProt Splice Variant |
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Entrez Gene |
17113
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UniGene |
Mm.471039
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RefSeq |
NP_034879
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MGI ID |
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MGI Symbol |
M6pr
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OMIM |
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CCDS |
CCDS20493
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HPRD |
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IMGT |
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EMBL |
AK133943
AK145913
AK151607
AK153302
BC027210
BC046956
BC080811
CH466523
M58585
M63286
X56831
X64068
X64070
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GenPept |
AAA39482
AAA39735
AAH27210
AAH46956
AAH80811
BAE21941
BAE26746
BAE30546
BAE31884
CAA40162
CAA45423
CAA45426
EDK99677
EDK99678
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