Mus musculus Gene: Ednrb
Summary
InnateDB Gene IDBG-185332.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ednrb
Gene Name endothelin receptor type B
Synonyms ET-B; ET-BR; ETb; ETR-b; Sox10m1;
Species Mus musculus
Ensembl Gene ENSMUSG00000022122
Encoded Proteins
endothelin receptor type B
endothelin receptor type B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the G-protein coupled receptor family. It encodes a receptor for endothelins, peptides that are involved in vasocontriction. The encoded protein activates a phosphatidylinositol-calcium second messenger system and is required for the development of enteric neurons and melanocytes. Gene disruption causes pigmentation anomalies, deafness, and abnormal dilation of the colon due to defects of neural crest-derived cells. Mutations in this gene are found in the piebald mouse, and mouse models of Hirschsprung's disease and Waardenburg syndrome type 4. Renal collecting duct-specific gene deletion causes sodium retention and hypertension. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
This gene encodes a member of the G-protein coupled receptor family. It encodes a receptor for endothelins, peptides that are involved in vasocontriction. The encoded protein activates a phosphatidylinositol-calcium second messenger system and is required for the development of enteric neurons and melanocytes. Gene disruption causes pigmentation anomalies, deafness, and abnormal dilation of the colon due to defects of neural crest-derived cells. Mutations in this gene are found in the piebald mouse, and mouse models of Hirschsprung\'s disease and Waardenburg syndrome type 4. Renal collecting duct-specific gene deletion causes sodium retention and hypertension. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:103814625-103844173
Strand Reverse strand
Band E2.3
Transcripts
ENSMUST00000022718 ENSMUSP00000022718
ENSMUST00000172237 ENSMUSP00000126057
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0004962 endothelin receptor activity
GO:0005515 protein binding
GO:0017046 peptide hormone binding
GO:0031702 type 1 angiotensin receptor binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001755 neural crest cell migration
GO:0001934 positive regulation of protein phosphorylation
GO:0006885 regulation of pH
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007422 peripheral nervous system development
GO:0007497 posterior midgut development
GO:0007568 aging
GO:0008217 regulation of blood pressure
GO:0008284 positive regulation of cell proliferation
GO:0014043 negative regulation of neuron maturation
GO:0014070 response to organic cyclic compound
GO:0014826 vein smooth muscle contraction
GO:0019233 sensory perception of pain
GO:0019934 cGMP-mediated signaling
GO:0030318 melanocyte differentiation
GO:0031620 regulation of fever generation
GO:0032269 negative regulation of cellular protein metabolic process
GO:0032496 response to lipopolysaccharide
GO:0035645 enteric smooth muscle cell differentiation
GO:0035810 positive regulation of urine volume
GO:0035815 positive regulation of renal sodium excretion
GO:0042045 epithelial fluid transport
GO:0042310 vasoconstriction
GO:0042311 vasodilation
GO:0043066 negative regulation of apoptotic process
GO:0043473 pigmentation
GO:0048066 developmental pigmentation
GO:0048246 macrophage chemotaxis
GO:0048265 response to pain
GO:0048484 enteric nervous system development
GO:0050678 regulation of epithelial cell proliferation
GO:0051930 regulation of sensory perception of pain
GO:0060406 positive regulation of penile erection
GO:0071222 cellular response to lipopolysaccharide
GO:0086100 endothelin receptor signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031965 nuclear membrane
GO:0045121 membrane raft
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
GPCR downstream signaling pathway
Signaling by GPCR pathway
Class A/1 (Rhodopsin-like receptors) pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
GPCR ligand binding pathway
Peptide ligand-binding receptors pathway
G alpha (q) signalling events pathway
Signal Transduction pathway
KEGG
Calcium signaling pathway pathway
Neuroactive ligand-receptor interaction pathway
Melanogenesis pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Gastrin-CREB signalling pathway via PKC and MAPK pathway
Class A/1 (Rhodopsin-like receptors) pathway
G alpha (q) signalling events pathway
Signaling by GPCR pathway
Peptide ligand-binding receptors pathway
Signal Transduction pathway
GPCR downstream signaling pathway
GPCR ligand binding pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
Peptide ligand-binding receptors pathway
Signaling by GPCR pathway
Signal Transduction pathway
G alpha (q) signalling events pathway
GPCR downstream signaling pathway
GPCR ligand binding pathway
Class A/1 (Rhodopsin-like receptors) pathway
KEGG
Calcium signaling pathway pathway
Neuroactive ligand-receptor interaction pathway
Melanogenesis pathway
INOH
PID BIOCARTA
Role of egf receptor transactivation by gpcrs in cardiac hypertrophy [Biocarta view]
PID NCI
Endothelins
Cross-References
SwissProt P48302
TrEMBL
UniProt Splice Variant
Entrez Gene 13618
UniGene Mm.229532 Mm.473083
RefSeq NM_001136061 NM_007904
OMIM
CCDS CCDS27317
HPRD
IMGT
MGI ID MGI:102720
MGI Symbol Ednrb
EMBL AK076426 AK082103 AK083415 AK085532 BC026553 U32329
GenPept AAB60508 AAH26553 BAC36337 BAC38409 BAC38908 BAC39465
RNA Seq Atlas 13618