InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Acvr1b

Summary

InnateDB Gene

IDBG-185560.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Acvr1b

Gene Name

activin A receptor, type 1B

Synonyms

6820432J04; ActR-IB; ActRIB; Acvrlk4; Alk4; SKR2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000000532

Encoded Proteins

IDBP-185562

activin A receptor, type 1B

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000135503:
This gene encodes an activin A type IB receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I and two type II receptors. This protein is a type I receptor which is essential for signaling. Mutations in this gene are associated with pituitary tumors. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jun 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:101174067-101213679

Strand

Forward strand

Band

Transcripts

ENSMUST00000000544

ENSMUSP00000000544

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	27 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004675	transmembrane receptor protein serine/threonine kinase activity
GO:0004702	receptor signaling protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005024	transforming growth factor beta-activated receptor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0017002	activin-activated receptor activity
GO:0019838	growth factor binding
GO:0034711	inhibin binding
GO:0046332	SMAD binding
GO:0046872	metal ion binding
GO:0048185	activin binding

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0001701	in utero embryonic development
GO:0001942	hair follicle development
GO:0006355	regulation of transcription, DNA-templated
GO:0006468	protein phosphorylation
GO:0007165	signal transduction
GO:0007166	cell surface receptor signaling pathway
GO:0007417	central nervous system development
GO:0007498	mesoderm development
GO:0009966	regulation of signal transduction
GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0018107	peptidyl-threonine phosphorylation
GO:0023014	signal transduction by phosphorylation
GO:0030308	negative regulation of cell growth
GO:0032924	activin receptor signaling pathway
GO:0032927	positive regulation of activin receptor signaling pathway
GO:0038092	nodal signaling pathway
GO:0045648	positive regulation of erythrocyte differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046545	development of primary female sexual characteristics
GO:0046777	protein autophosphorylation
GO:0097191	extrinsic apoptotic signaling pathway
GO:1901165	positive regulation of trophoblast cell migration

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome