Mus musculus Gene: Acvr1b
Summary
InnateDB Gene IDBG-185560.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Acvr1b
Gene Name activin A receptor, type 1B
Synonyms 6820432J04; ActR-IB; ActRIB; Acvrlk4; Alk4; SKR2;
Species Mus musculus
Ensembl Gene ENSMUSG00000000532
Encoded Proteins
activin A receptor, type 1B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000135503:
This gene encodes an activin A type IB receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I and two type II receptors. This protein is a type I receptor which is essential for signaling. Mutations in this gene are associated with pituitary tumors. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jun 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:101174067-101213679
Strand Forward strand
Band F1
Transcripts
ENSMUST00000000544 ENSMUSP00000000544
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 27 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004675 transmembrane receptor protein serine/threonine kinase activity
GO:0004702 receptor signaling protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005024 transforming growth factor beta-activated receptor activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0017002 activin-activated receptor activity
GO:0019838 growth factor binding
GO:0034711 inhibin binding
GO:0046332 SMAD binding
GO:0046872 metal ion binding
GO:0048185 activin binding
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0001701 in utero embryonic development
GO:0001942 hair follicle development
GO:0006355 regulation of transcription, DNA-templated
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0007417 central nervous system development
GO:0007498 mesoderm development
GO:0009966 regulation of signal transduction
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0023014 signal transduction by phosphorylation
GO:0030308 negative regulation of cell growth
GO:0032924 activin receptor signaling pathway
GO:0032927 positive regulation of activin receptor signaling pathway
GO:0038092 nodal signaling pathway
GO:0045648 positive regulation of erythrocyte differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046545 development of primary female sexual characteristics
GO:0046777 protein autophosphorylation
GO:0097191 extrinsic apoptotic signaling pathway
GO:1901165 positive regulation of trophoblast cell migration
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Signaling by NODAL pathway
Signaling by Activin pathway
Developmental Biology pathway
Signal Transduction pathway
KEGG
Cytokine-cytokine receptor interaction pathway
TGF-beta signaling pathway pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Developmental Biology pathway
Regulation of signaling by NODAL pathway
Signal Transduction pathway
Signaling by NODAL pathway
Signaling by Activin pathway
KEGG
Cytokine-cytokine receptor interaction pathway
TGF-beta signaling pathway pathway
INOH
TGF-beta signaling pathway
BMP2 signaling pathway
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q61271
TrEMBL Q3TZF1
UniProt Splice Variant
Entrez Gene 11479
UniGene Mm.308467 Mm.414401
RefSeq NM_007395 XM_006520302
OMIM
CCDS CCDS27846
HPRD
IMGT
MGI ID MGI:1338944
MGI Symbol Acvr1b
EMBL AK157910 BC145775 BC145777 Z31663
GenPept AAI45776 AAI45778 BAE34258 CAA83483
RNA Seq Atlas 11479