InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ACVR1B

Summary

InnateDB Gene

IDBG-33695.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ACVR1B

Gene Name

activin A receptor, type IB

Synonyms

ACTRIB; ACVRLK4; ALK4; SKR2

Species

Homo sapiens

Ensembl Gene

ENSG00000135503

Encoded Proteins

IDBP-33697

activin A receptor, type IB

IDBP-375358

activin A receptor, type IB

IDBP-375359

activin A receptor, type IB

IDBP-594353

activin A receptor, type IB

IDBP-585828

activin A receptor, type IB

IDBP-601570

activin A receptor, type IB

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes an activin A type IB receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I and two type II receptors. This protein is a type I receptor which is essential for signaling. Mutations in this gene are associated with pituitary tumors. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jun 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:51951667-51997078

Strand

Forward strand

Band

q13.13

Transcripts

ENST00000257963	ENSP00000257963
ENST00000426655	ENSP00000390477
ENST00000415850	ENSP00000397550
ENST00000541224	ENSP00000442656
ENST00000536420	ENSP00000443218
ENST00000542485	ENSP00000442885
ENST00000563121

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	39 [view]
Protein-Protein	38 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	1 [view]
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004675	transmembrane receptor protein serine/threonine kinase activity
GO:0004702	receptor signaling protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005024	transforming growth factor beta-activated receptor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016361	activin receptor activity, type I
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0017002	activin-activated receptor activity
GO:0019838	growth factor binding
GO:0031625	ubiquitin protein ligase binding
GO:0034711	inhibin binding
GO:0046332	SMAD binding
GO:0046872	metal ion binding
GO:0048185	activin binding

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0001701	in utero embryonic development
GO:0001942	hair follicle development
GO:0006355	regulation of transcription, DNA-templated
GO:0006468	protein phosphorylation
GO:0007165	signal transduction
GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0007417	central nervous system development
GO:0009966	regulation of signal transduction
GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0018107	peptidyl-threonine phosphorylation
GO:0030308	negative regulation of cell growth
GO:0032924	activin receptor signaling pathway
GO:0032927	positive regulation of activin receptor signaling pathway
GO:0038092	nodal signaling pathway
GO:0045648	positive regulation of erythrocyte differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046545	development of primary female sexual characteristics
GO:0046777	protein autophosphorylation
GO:0097191	extrinsic apoptotic signaling pathway
GO:1901165	positive regulation of trophoblast cell migration

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome