Mus musculus Gene: Nae1
Summary
InnateDB Gene IDBG-185610.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nae1
Gene Name NEDD8 activating enzyme E1 subunit 1
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000031878
Encoded Proteins
NEDD8 activating enzyme E1 subunit 1
NEDD8 activating enzyme E1 subunit 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000159593:
The protein encoded by this gene binds to the beta-amyloid precursor protein. Beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. In addition, the encoded protein can form a heterodimer with UBE1C and bind and activate NEDD8, a ubiquitin-like protein. This protein is required for cell cycle progression through the S/M checkpoint. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
The protein encoded by this gene binds to the beta-amyloid precursor protein. Beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer\'s disease. In addition, the encoded protein can form a heterodimer with UBE1C and bind and activate NEDD8, a ubiquitin-like protein. This protein is required for cell cycle progression through the S/M checkpoint. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:104511028-104534637
Strand Reverse strand
Band D3
Transcripts
ENSMUST00000034349 ENSMUSP00000034349
ENSMUST00000162466 ENSMUSP00000125456
ENSMUST00000161462
ENSMUST00000161411
ENSMUST00000159330
ENSMUST00000160148
ENSMUST00000160913
ENSMUST00000159696
ENSMUST00000159393
ENSMUST00000161474
ENSMUST00000159702
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0005515 protein binding
GO:0019781 NEDD8 activating enzyme activity
GO:0031625 ubiquitin protein ligase binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0033314 mitotic DNA replication checkpoint
GO:0042981 regulation of apoptotic process
GO:0043523 regulation of neuron apoptotic process
GO:0045116 protein neddylation
GO:0051402 neuron apoptotic process
Cellular Component
GO:0005886 plasma membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Alzheimer's disease pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
Alzheimer's disease pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.237670 Mm.411408
RefSeq NM_144931 XM_006530884
OMIM
CCDS CCDS40452
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas