InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Nae1

Summary

InnateDB Gene

IDBG-185610.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nae1

Gene Name

NEDD8 activating enzyme E1 subunit 1

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000031878

Encoded Proteins

IDBP-185612

NEDD8 activating enzyme E1 subunit 1

IDBP-538380

NEDD8 activating enzyme E1 subunit 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000159593:
The protein encoded by this gene binds to the beta-amyloid precursor protein. Beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. In addition, the encoded protein can form a heterodimer with UBE1C and bind and activate NEDD8, a ubiquitin-like protein. This protein is required for cell cycle progression through the S/M checkpoint. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
The protein encoded by this gene binds to the beta-amyloid precursor protein. Beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer\'s disease. In addition, the encoded protein can form a heterodimer with UBE1C and bind and activate NEDD8, a ubiquitin-like protein. This protein is required for cell cycle progression through the S/M checkpoint. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:104511028-104534637

Strand

Reverse strand

Band

Transcripts

ENSMUST00000034349	ENSMUSP00000034349
ENSMUST00000162466	ENSMUSP00000125456
ENSMUST00000161462
ENSMUST00000161411
ENSMUST00000159330
ENSMUST00000160148
ENSMUST00000160913
ENSMUST00000159696
ENSMUST00000159393
ENSMUST00000161474
ENSMUST00000159702

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0005515	protein binding
GO:0019781	NEDD8 activating enzyme activity
GO:0031625	ubiquitin protein ligase binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0033314	mitotic DNA replication checkpoint
GO:0042981	regulation of apoptotic process
GO:0043523	regulation of neuron apoptotic process
GO:0045116	protein neddylation
GO:0051402	neuron apoptotic process

Cellular Component

GO:0005886

plasma membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000159593

View Gene Order

ENSBTAG00000010132

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu05010

Alzheimer's disease pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa05010

Alzheimer's disease pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.237670 Mm.411408

RefSeq

NM_144931 XM_006530884

OMIM

CCDS

CCDS40452

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas