InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: NAE1

Summary

InnateDB Gene

IDBG-35583.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NAE1

Gene Name

NEDD8 activating enzyme E1 subunit 1

Synonyms

A-116A10.1; APPBP1; ula-1

Species

Homo sapiens

Ensembl Gene

ENSG00000159593

Encoded Proteins

IDBP-35585

NEDD8 activating enzyme E1 subunit 1

IDBP-35587

NEDD8 activating enzyme E1 subunit 1

IDBP-35589

NEDD8 activating enzyme E1 subunit 1

IDBP-242293

NEDD8 activating enzyme E1 subunit 1

IDBP-746187

IDBP-747625

IDBP-748717

IDBP-748984

IDBP-749137

IDBP-751186

IDBP-745163

IDBP-753880

IDBP-751969

IDBP-747620

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene binds to the beta-amyloid precursor protein. Beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. In addition, the encoded protein can form a heterodimer with UBE1C and bind and activate NEDD8, a ubiquitin-like protein. This protein is required for cell cycle progression through the S/M checkpoint. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
The protein encoded by this gene binds to the beta-amyloid precursor protein. Beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer\'s disease. In addition, the encoded protein can form a heterodimer with UBE1C and bind and activate NEDD8, a ubiquitin-like protein. This protein is required for cell cycle progression through the S/M checkpoint. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:66802875-66873256

Strand

Reverse strand

Band

q22.1

Transcripts

ENST00000379463	ENSP00000368776
ENST00000359087	ENSP00000351990
ENST00000290810	ENSP00000290810
ENST00000394074	ENSP00000377637
ENST00000567743	ENSP00000455562
ENST00000568672
ENST00000563419
ENST00000569963
ENST00000562428	ENSP00000463546
ENST00000569348	ENSP00000456564
ENST00000566663	ENSP00000462937
ENST00000566336	ENSP00000462040
ENST00000561579	ENSP00000464119
ENST00000567521
ENST00000563253	ENSP00000454471
ENST00000563221
ENST00000563185	ENSP00000454506
ENST00000562074
ENST00000569388	ENSP00000456847
ENST00000564040
ENST00000562757
ENST00000565535	ENSP00000455967

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 44 experimentally validated interaction(s) in this database.

Experimentally validated
Total	44 [view]
Protein-Protein	44 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0005515	protein binding
GO:0019781	NEDD8 activating enzyme activity
GO:0031625	ubiquitin protein ligase binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0007165	signal transduction
GO:0008152	metabolic process
GO:0033314	mitotic DNA replication checkpoint
GO:0042981	regulation of apoptotic process
GO:0043523	regulation of neuron apoptotic process
GO:0045116	protein neddylation
GO:0051402	neuron apoptotic process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000031878

View Gene Order

ENSBTAG00000010132

Not yet available

Pathways

NETPATH

REACTOME

KEGG

hsa05010

Alzheimer's disease pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.460978 Hs.713192

RefSeq

NM_001018159 NM_001018160 NM_001286500 NM_003905 XM_005256215

HUGO

OMIM

CCDS

CCDS10820 CCDS42171 CCDS42172 CCDS67050

HPRD

04545

IMGT

EMBL

GenPept

RNA Seq Atlas