Homo sapiens Gene: NAE1
Summary
InnateDB Gene IDBG-35583.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NAE1
Gene Name NEDD8 activating enzyme E1 subunit 1
Synonyms A-116A10.1; APPBP1; ula-1;
Species Homo sapiens
Ensembl Gene ENSG00000159593
Encoded Proteins
NEDD8 activating enzyme E1 subunit 1
NEDD8 activating enzyme E1 subunit 1
NEDD8 activating enzyme E1 subunit 1
NEDD8 activating enzyme E1 subunit 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene binds to the beta-amyloid precursor protein. Beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. In addition, the encoded protein can form a heterodimer with UBE1C and bind and activate NEDD8, a ubiquitin-like protein. This protein is required for cell cycle progression through the S/M checkpoint. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
The protein encoded by this gene binds to the beta-amyloid precursor protein. Beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer\'s disease. In addition, the encoded protein can form a heterodimer with UBE1C and bind and activate NEDD8, a ubiquitin-like protein. This protein is required for cell cycle progression through the S/M checkpoint. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:66802875-66873256
Strand Reverse strand
Band q22.1
Transcripts
ENST00000379463 ENSP00000368776
ENST00000359087 ENSP00000351990
ENST00000290810 ENSP00000290810
ENST00000394074 ENSP00000377637
ENST00000567743 ENSP00000455562
ENST00000568672
ENST00000563419
ENST00000569963
ENST00000562428 ENSP00000463546
ENST00000569348 ENSP00000456564
ENST00000566663 ENSP00000462937
ENST00000566336 ENSP00000462040
ENST00000561579 ENSP00000464119
ENST00000567521
ENST00000563253 ENSP00000454471
ENST00000563221
ENST00000563185 ENSP00000454506
ENST00000562074
ENST00000569388 ENSP00000456847
ENST00000564040
ENST00000562757
ENST00000565535 ENSP00000455967
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 44 experimentally validated interaction(s) in this database.
Experimentally validated
Total 44 [view]
Protein-Protein 44 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0005515 protein binding
GO:0019781 NEDD8 activating enzyme activity
GO:0031625 ubiquitin protein ligase binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0007165 signal transduction
GO:0008152 metabolic process
GO:0033314 mitotic DNA replication checkpoint
GO:0042981 regulation of apoptotic process
GO:0043523 regulation of neuron apoptotic process
GO:0045116 protein neddylation
GO:0051402 neuron apoptotic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Alzheimer's disease pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL H3BS69
UniProt Splice Variant
Entrez Gene 8883
UniGene Hs.460978 Hs.713192
RefSeq NM_001018159 NM_001286500 NM_003905 NM_001018160 XM_005256215
HUGO HGNC:621
OMIM 603385
CCDS CCDS42171 CCDS67050 CCDS10820 CCDS42172
HPRD 04545
IMGT
EMBL AC044802
GenPept
RNA Seq Atlas 8883