Version 5.4
Mus musculus Gene: Nr4a1
Summary
InnateDB Gene IDBG-185628.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nr4a1
Gene Name nuclear receptor subfamily 4, group A, member 1
Synonyms Gfrp; GFRP1; Hbr-1; Hbr1; Hmr; N10; NGFI-B; NGFIB; NP10; nur77; TIS1; TR3;
Species Mus musculus
Ensembl Gene ENSMUSG00000023034
Encoded Proteins
IDBP-185630
nuclear receptor subfamily 4, group A, member 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000123358:
This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:101266846-101274792
Strand Forward strand
Band F1
Transcripts
ENSMUST00000023779 ENSMUSP00000023779
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 98 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 98 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003707 steroid hormone receptor activity
GO:0004879 ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0042803 protein homodimerization activity
GO:0043565 sequence-specific DNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0001938 positive regulation of endothelial cell proliferation
GO:0002042 cell migration involved in sprouting angiogenesis
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006915 apoptotic process
GO:0010035 response to inorganic substance
GO:0030522 intracellular receptor signaling pathway
GO:0035767 endothelial cell chemotaxis
GO:0035914 skeletal muscle cell differentiation
GO:0035924 cellular response to vascular endothelial growth factor stimulus
GO:0043065 positive regulation of apoptotic process
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043401 steroid hormone mediated signaling pathway
GO:0044344 cellular response to fibroblast growth factor stimulus
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0071310 cellular response to organic substance
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
ENSG00000123358
View Gene Order
Ortholuge
SSD Ortholog
Ortholog supports species divergence
ENSBTAG00000000507
Not yet available
Ortholuge
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
REACT_239142
Innate Immune System pathway
REACT_188199
Signaling by the B Cell Receptor (BCR) pathway
REACT_188191
Signaling by ERBB2 pathway
REACT_205300
PI3K/AKT activation pathway
REACT_189085
Disease pathway
REACT_234105
Nuclear Receptor transcription pathway pathway
REACT_188177
Signaling by FGFR in disease pathway
REACT_188579
Signaling by ERBB4 pathway
REACT_188578
Signaling by SCF-KIT pathway
REACT_226341
PIP3 activates AKT signaling pathway
REACT_230745
Immune System pathway
REACT_230639
Downstream signal transduction pathway
REACT_231729
Downstream signaling of activated FGFR pathway
REACT_196588
Constitutive PI3K/AKT Signaling in Cancer pathway
REACT_203296
PI3K events in ERBB4 signaling pathway
REACT_223993
PI-3K cascade pathway
REACT_218211
AKT phosphorylates targets in the nucleus pathway
REACT_242976
Signaling by EGFR pathway
REACT_213364
Role of LAT2/NTAL/LAB on calcium mobilization pathway
REACT_188204
Fc epsilon receptor (FCERI) signaling pathway
REACT_226735
PI3K/AKT Signaling in Cancer pathway
REACT_248921
Signalling by NGF pathway
REACT_233572
Gene Expression pathway
REACT_229531
Adaptive Immune System pathway
REACT_263353
Signaling by PDGF pathway
REACT_206286
GAB1 signalosome pathway
REACT_237883
NGF signalling via TRKA from the plasma membrane pathway
REACT_206529
Generic Transcription Pathway pathway
REACT_215348
PI3K events in ERBB2 signaling pathway
REACT_188257
Signal Transduction pathway
REACT_242456
Signaling by FGFR pathway
REACT_188180
Signaling by EGFR in Cancer pathway
REACT_209507
Downstream signaling events of B Cell Receptor (BCR) pathway
REACT_188188
DAP12 interactions pathway
REACT_188185
DAP12 signaling pathway
KEGG
mmu04010
MAPK signaling pathway pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_11
TCR pathway
REACTOME
REACT_120736
Signaling by FGFR in disease pathway
REACT_11061
Signalling by NGF pathway
REACT_115871
Signaling by EGFR in Cancer pathway
REACT_12464
PI3K/AKT activation pathway
REACT_21272
Downstream signaling of activated FGFR pathway
REACT_21270
PI-3K cascade pathway
REACT_116008
PI3K events in ERBB2 signaling pathway
REACT_147814
DAP12 signaling pathway
REACT_9417
Signaling by EGFR pathway
REACT_163769
Role of LAT2/NTAL/LAB on calcium mobilization pathway
REACT_147727
Constitutive PI3K/AKT Signaling in Cancer pathway
REACT_6802
Innate Immune System pathway
REACT_115596
Signaling by ERBB4 pathway
REACT_111040
Signaling by SCF-KIT pathway
REACT_163936
Fc epsilon receptor (FCERI) signaling pathway
REACT_111102
Signal Transduction pathway
REACT_15525
Nuclear Receptor transcription pathway pathway
REACT_12627
Generic Transcription Pathway pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_17025
Downstream signal transduction pathway
REACT_12056
NGF signalling via TRKA from the plasma membrane pathway
REACT_147723
PI3K/AKT Signaling in Cancer pathway
REACT_9470
Signaling by FGFR pathway
REACT_75829
PIP3 activates AKT signaling pathway
REACT_16888
Signaling by PDGF pathway
REACT_115755
Signaling by ERBB2 pathway
REACT_118773
Signaling by the B Cell Receptor (BCR) pathway
REACT_12578
GAB1 signalosome pathway
REACT_118638
Downstream signaling events of B Cell Receptor (BCR) pathway
REACT_12442
AKT phosphorylates targets in the nucleus pathway
REACT_71
Gene Expression pathway
REACT_116125
Disease pathway
REACT_115961
PI3K events in ERBB4 signaling pathway
REACT_147694
DAP12 interactions pathway
REACT_217956
DAP12 interactions pathway
REACT_227938
Generic Transcription Pathway pathway
REACT_208036
Signaling by EGFR pathway
REACT_222082
GAB1 signalosome pathway
REACT_204365
Signaling by PDGF pathway
REACT_216183
Signaling by ERBB4 pathway
REACT_202211
AKT phosphorylates targets in the nucleus pathway
REACT_202837
Signaling by FGFR pathway
REACT_226022
Gene Expression pathway
REACT_215558
Downstream signaling events of B Cell Receptor (BCR) pathway
REACT_219416
PI3K events in ERBB2 signaling pathway
REACT_213138
Immune System pathway
REACT_215895
Constitutive PI3K/AKT Signaling in Cancer pathway
REACT_205435
Signaling by the B Cell Receptor (BCR) pathway
REACT_218958
Signaling by ERBB2 pathway
REACT_214353
Signal Transduction pathway
REACT_221368
Signaling by EGFR in Cancer pathway
REACT_204467
PI-3K cascade pathway
REACT_207949
NGF signalling via TRKA from the plasma membrane pathway
REACT_222492
PI3K events in ERBB4 signaling pathway
REACT_206613
Downstream signaling of activated FGFR pathway
REACT_210423
Nuclear Receptor transcription pathway pathway
REACT_207066
Signalling by NGF pathway
REACT_221870
PI3K/AKT Signaling in Cancer pathway
REACT_224097
Role of LAT2/NTAL/LAB on calcium mobilization pathway
REACT_214469
Adaptive Immune System pathway
REACT_212750
Downstream signal transduction pathway
REACT_208171
PIP3 activates AKT signaling pathway
REACT_204114
Signaling by SCF-KIT pathway
REACT_216714
Innate Immune System pathway
REACT_225332
PI3K/AKT activation pathway
REACT_214988
DAP12 signaling pathway
REACT_207087
Disease pathway
REACT_203736
Signaling by FGFR in disease pathway
REACT_225357
Fc epsilon receptor (FCERI) signaling pathway
KEGG
hsa04010
MAPK signaling pathway pathway
INOH
PID BIOCARTA
100109
Role of mef2d in t-cell apoptosis [Biocarta view]
PID NCI
rxr_vdr_pathway
RXR and RAR heterodimerization with other nuclear receptor
reg_gr_pathway
Glucocorticoid receptor regulatory network
nfat_3pathway
Role of Calcineurin-dependent NFAT signaling in lymphocytes
Cross-References
SwissProt P12813
TrEMBL Q545Q1
UniProt Splice Variant
Entrez Gene 15370
UniGene Mm.119
RefSeq NM_010444 XM_006520455 XM_006520456 XM_006520457 XM_006520458 XM_006520459
OMIM
CCDS CCDS27848
HPRD
IMGT
MGI ID MGI:1352454
MGI Symbol Nr4a1
EMBL AK004709 AK157203 BC004770 CH466550 CT010287 J04113 X16995 X60132
GenPept AAA39843 AAH04770 BAB23493 BAE33997 CAA34862 CAA42718 CAJ18495 EDL04054
RNA Seq Atlas 15370

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca