Mus musculus Gene: Nr4a1 | |||||||||||||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||||||||||||
InnateDB Gene | IDBG-185628.6 | ||||||||||||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||||||||||
Gene Symbol | Nr4a1 | ||||||||||||||||||||||||||||||||||
Gene Name | nuclear receptor subfamily 4, group A, member 1 | ||||||||||||||||||||||||||||||||||
Synonyms | Gfrp; GFRP1; Hbr-1; Hbr1; Hmr; N10; NGFI-B; NGFIB; NP10; nur77; TIS1; TR3 | ||||||||||||||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||||||||||||||
Ensembl Gene | ENSMUSG00000023034 | ||||||||||||||||||||||||||||||||||
Encoded Proteins |
nuclear receptor subfamily 4, group A, member 1
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Protein Structure |
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Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000123358:
This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011] |
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Gene Information | |||||||||||||||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||||||||||||||
Genomic Location | Chromosome 15:101266846-101274792 | ||||||||||||||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||||||||||||||
Band | F1 | ||||||||||||||||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 98 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||||||||||||||
Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||||||||||||||
REACTOME |
Innate Immune System pathway
Signaling by the B Cell Receptor (BCR) pathway
Signaling by ERBB2 pathway
PI3K/AKT activation pathway
Disease pathway
Nuclear Receptor transcription pathway pathway
Signaling by FGFR in disease pathway
Signaling by ERBB4 pathway
Signaling by SCF-KIT pathway
PIP3 activates AKT signaling pathway
Immune System pathway
Downstream signal transduction pathway
Downstream signaling of activated FGFR pathway
Constitutive PI3K/AKT Signaling in Cancer pathway
PI3K events in ERBB4 signaling pathway
PI-3K cascade pathway
AKT phosphorylates targets in the nucleus pathway
Signaling by EGFR pathway
Role of LAT2/NTAL/LAB on calcium mobilization pathway
Fc epsilon receptor (FCERI) signaling pathway
PI3K/AKT Signaling in Cancer pathway
Signalling by NGF pathway
Gene Expression pathway
Adaptive Immune System pathway
Signaling by PDGF pathway
GAB1 signalosome pathway
NGF signalling via TRKA from the plasma membrane pathway
Generic Transcription Pathway pathway
PI3K events in ERBB2 signaling pathway
Signal Transduction pathway
Signaling by FGFR pathway
Signaling by EGFR in Cancer pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
DAP12 interactions pathway
DAP12 signaling pathway
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KEGG |
MAPK signaling pathway pathway
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INOH | |||||||||||||||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||||||||||||||
NETPATH |
TCR pathway
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REACTOME |
AKT phosphorylates targets in the nucleus pathway
PIP3 activates AKT signaling pathway
DAP12 signaling pathway
DAP12 interactions pathway
PI3K/AKT activation pathway
GAB1 signalosome pathway
Signaling by EGFR pathway
PI3K events in ERBB4 signaling pathway
Signaling by ERBB4 pathway
PI3K events in ERBB2 signaling pathway
Signaling by ERBB2 pathway
PI-3K cascade pathway
Signaling by FGFR pathway
Signaling by SCF-KIT pathway
Downstream signal transduction pathway
Signaling by PDGF pathway
Constitutive PI3K/AKT Signaling in Cancer pathway
Nuclear Receptor transcription pathway pathway
Generic Transcription Pathway pathway
Signaling by FGFR in disease pathway
Signalling by NGF pathway
Signaling by EGFR in Cancer pathway
Downstream signaling of activated FGFR pathway
Role of LAT2/NTAL/LAB on calcium mobilization pathway
Innate Immune System pathway
Fc epsilon receptor (FCERI) signaling pathway
Signal Transduction pathway
Adaptive Immune System pathway
Immune System pathway
NGF signalling via TRKA from the plasma membrane pathway
PI3K/AKT Signaling in Cancer pathway
Signaling by the B Cell Receptor (BCR) pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
Gene Expression pathway
Disease pathway
DAP12 interactions pathway
Generic Transcription Pathway pathway
Signaling by EGFR pathway
GAB1 signalosome pathway
Signaling by PDGF pathway
Signaling by ERBB4 pathway
AKT phosphorylates targets in the nucleus pathway
Signaling by FGFR pathway
Gene Expression pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
PI3K events in ERBB2 signaling pathway
Immune System pathway
Constitutive PI3K/AKT Signaling in Cancer pathway
Signaling by the B Cell Receptor (BCR) pathway
Signaling by ERBB2 pathway
Signal Transduction pathway
Signaling by EGFR in Cancer pathway
PI-3K cascade pathway
NGF signalling via TRKA from the plasma membrane pathway
PI3K events in ERBB4 signaling pathway
Downstream signaling of activated FGFR pathway
Nuclear Receptor transcription pathway pathway
Signalling by NGF pathway
PI3K/AKT Signaling in Cancer pathway
Role of LAT2/NTAL/LAB on calcium mobilization pathway
Adaptive Immune System pathway
Downstream signal transduction pathway
PIP3 activates AKT signaling pathway
Signaling by SCF-KIT pathway
Innate Immune System pathway
PI3K/AKT activation pathway
DAP12 signaling pathway
Disease pathway
Signaling by FGFR in disease pathway
Fc epsilon receptor (FCERI) signaling pathway
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KEGG |
MAPK signaling pathway pathway
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INOH | |||||||||||||||||||||||||||||||||||
PID NCI |
RXR and RAR heterodimerization with other nuclear receptor
Glucocorticoid receptor regulatory network
Role of Calcineurin-dependent NFAT signaling in lymphocytes
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Cross-References | |||||||||||||||||||||||||||||||||||
SwissProt | P12813 | ||||||||||||||||||||||||||||||||||
TrEMBL | Q545Q1 | ||||||||||||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||||||||||||
Entrez Gene | 15370 | ||||||||||||||||||||||||||||||||||
UniGene | Mm.119 | ||||||||||||||||||||||||||||||||||
RefSeq | NM_010444 XM_006520455 XM_006520456 XM_006520457 XM_006520458 XM_006520459 | ||||||||||||||||||||||||||||||||||
OMIM | |||||||||||||||||||||||||||||||||||
CCDS | CCDS27848 | ||||||||||||||||||||||||||||||||||
HPRD | |||||||||||||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||||||||||||
MGI ID | MGI:1352454 | ||||||||||||||||||||||||||||||||||
MGI Symbol | Nr4a1 | ||||||||||||||||||||||||||||||||||
EMBL | AK004709 AK157203 BC004770 CH466550 CT010287 J04113 X16995 X60132 | ||||||||||||||||||||||||||||||||||
GenPept | AAA39843 AAH04770 BAB23493 BAE33997 CAA34862 CAA42718 CAJ18495 EDL04054 | ||||||||||||||||||||||||||||||||||
RNA Seq Atlas | 15370 | ||||||||||||||||||||||||||||||||||