InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: MAP2K5

Summary

InnateDB Gene

IDBG-18592.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAP2K5

Gene Name

mitogen-activated protein kinase kinase 5

Synonyms

HsT17454; MAPKK5; MEK5; PRKMK5

Species

Homo sapiens

Ensembl Gene

ENSG00000137764

Encoded Proteins

IDBP-18594

mitogen-activated protein kinase kinase 5

IDBP-18596

mitogen-activated protein kinase kinase 5

IDBP-18598

mitogen-activated protein kinase kinase 5

IDBP-239443

mitogen-activated protein kinase kinase 5

IDBP-376139

mitogen-activated protein kinase kinase 5

IDBP-808301

mitogen-activated protein kinase kinase 5

IDBP-808305

mitogen-activated protein kinase kinase 5

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been described. [provided by RefSeq, May 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:67542709-67807123

Strand

Forward strand

Band

q23

Transcripts

ENST00000178640	ENSP00000178640
ENST00000354498	ENSP00000346493
ENST00000340972	ENSP00000342101
ENST00000395476	ENSP00000378859
ENST00000439036	ENSP00000390196
ENST00000560591
ENST00000560086
ENST00000558392
ENST00000559262	ENSP00000480580
ENST00000557869	ENSP00000483771
ENST00000558274
ENST00000558021

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	34 [view]
Protein-Protein	29 [view]
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000165	MAPK cascade
GO:0000187	activation of MAPK activity
GO:0006468	protein phosphorylation
GO:0007165	signal transduction
GO:0007507	heart development
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0030307	positive regulation of cell growth
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0034115	negative regulation of heterotypic cell-cell adhesion
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045415	negative regulation of interleukin-8 biosynthetic process
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0050679	positive regulation of epithelial cell proliferation
GO:0051247	positive regulation of protein metabolic process
GO:0060761	negative regulation of response to cytokine stimulus
GO:0070375	ERK5 cascade
GO:0071363	cellular response to growth factor stimulus
GO:0071499	cellular response to laminar fluid shear stress
GO:0090051	negative regulation of cell migration involved in sprouting angiogenesis
GO:2000342	negative regulation of chemokine (C-X-C motif) ligand 2 production
GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand