Homo sapiens Gene: MAP2K5
Summary
InnateDB Gene IDBG-18592.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MAP2K5
Gene Name mitogen-activated protein kinase kinase 5
Synonyms HsT17454; MAPKK5; MEK5; PRKMK5;
Species Homo sapiens
Ensembl Gene ENSG00000137764
Encoded Proteins
mitogen-activated protein kinase kinase 5
mitogen-activated protein kinase kinase 5
mitogen-activated protein kinase kinase 5
mitogen-activated protein kinase kinase 5
mitogen-activated protein kinase kinase 5
mitogen-activated protein kinase kinase 5
mitogen-activated protein kinase kinase 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been described. [provided by RefSeq, May 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:67542709-67807123
Strand Forward strand
Band q23
Transcripts
ENST00000178640 ENSP00000178640
ENST00000354498 ENSP00000346493
ENST00000340972 ENSP00000342101
ENST00000395476 ENSP00000378859
ENST00000439036 ENSP00000390196
ENST00000560591
ENST00000560086
ENST00000558392
ENST00000559262 ENSP00000480580
ENST00000557869 ENSP00000483771
ENST00000558274
ENST00000558021
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated
Total 34 [view]
Protein-Protein 29 [view]
Protein-DNA 5 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0046872 metal ion binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0000165 MAPK cascade
GO:0000187 activation of MAPK activity
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0007507 heart development
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0030307 positive regulation of cell growth
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0034115 negative regulation of heterotypic cell-cell adhesion
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045415 negative regulation of interleukin-8 biosynthetic process
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0050679 positive regulation of epithelial cell proliferation
GO:0051247 positive regulation of protein metabolic process
GO:0060761 negative regulation of response to cytokine stimulus
GO:0070375 ERK5 cascade
GO:0071363 cellular response to growth factor stimulus
GO:0071499 cellular response to laminar fluid shear stress
GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis
GO:2000342 negative regulation of chemokine (C-X-C motif) ligand 2 production
GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
Cellular Component
GO:0005634 nucleus
GO:0005819 spindle
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
EGFR1 pathway
TNFalpha pathway
REACTOME
Signalling by NGF pathway
Signal Transduction pathway
NGF signalling via TRKA from the plasma membrane pathway
Signalling to ERK5 pathway
KEGG
MAPK signaling pathway pathway
Gap junction pathway
Neurotrophin signaling pathway pathway
INOH
IL-7 signaling pathway
IL-1 signaling pathway pathway
Toll-like receptor signaling pathway pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
PID BIOCARTA
Mapkinase signaling pathway [Biocarta view]
Role of erk5 in neuronal survival pathway [Biocarta view]
PID NCI
Trk receptor signaling mediated by the MAPK pathway
ErbB1 downstream signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001206804 NM_002757 NM_145160
HUGO
OMIM
CCDS CCDS10224 CCDS42051 CCDS55970
HPRD 03951
IMGT
EMBL
GenPept
RNA Seq Atlas