InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MAP2K5

Summary

InnateDB Protein

IDBP-239443.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAP2K5

Protein Name

mitogen-activated protein kinase kinase 5

Synonyms

HsT17454; MAPKK5; MEK5; PRKMK5;

Species

Homo sapiens

Ensembl Protein

ENSP00000378859

InnateDB Gene

IDBG-18592 (MAP2K5)

Protein Structure

UniProt Annotation

Function

Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis. {ECO:0000269PubMed:7759517, ECO:0000269PubMed:9384584}.

Subcellular Localization

Disease Associations

Tissue Specificity

Expressed in many adult tissues. Abundant in heart and skeletal muscle.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	34 [view]
Protein-Protein	29 [view]
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000187	activation of MAPK activity
GO:0006468	protein phosphorylation
GO:0007165	signal transduction
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0034115	negative regulation of heterotypic cell-cell adhesion
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045415	negative regulation of interleukin-8 biosynthetic process
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0051247	positive regulation of protein metabolic process
GO:0060761	negative regulation of response to cytokine stimulus
GO:0071363	cellular response to growth factor stimulus
GO:0071499	cellular response to laminar fluid shear stress
GO:0090051	negative regulation of cell migration involved in sprouting angiogenesis
GO:2000342	negative regulation of chemokine (C-X-C motif) ligand 2 production
GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Cellular Component

Protein Structure and Domains

PDB ID

InterPro

IPR000270 Phox/Bem1p
IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00564
PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00666
SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt