Mus musculus Gene: Clec4n
Summary
InnateDB Gene IDBG-186283.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Clec4n
Gene Name C-type lectin domain family 4, member n
Synonyms Clec6a; Clecsf10; Nkcl;
Species Mus musculus
Ensembl Gene ENSMUSG00000023349
Encoded Proteins
C-type lectin domain family 4, member n
C-type lectin domain family 4, member n
C-type lectin domain family 4, member n
C-type lectin domain family 4, member n
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
Clec4n, a C-type lectin receptor, is a pattern recognition receptor critical for immune responses to fungi. Clec4n is coupled to Syk kinase and signals via Card9 to activate NFKB, which in turns induces both innate and adaptive immunity.
Clec4n is critical for the development of house dust mite (Dermatophagoides farinae) elicited eosinophilic and neutrophilic pulmonary inflammation. Clec4n was also found to be crucial for the Th2 cytokine induction in the lungs and re-stimulated lymph nodes.
Clec4n is expressed mainly in DCs and macrophages. Clec4n recognizes alpha-mannans with its carbohydrate recognition domain and transduces signals through association with the ITAM-containing Fc receptor gamma chain, which recruits Syk and initiates the Card9/NFkB signalling cascade.
Pik3cd regulates Clec4n signalling and the generation of Th2 and Th17 immunity.
InnateDB Annotation from Orthologs
Summary
[Homo sapiens] CLEC6A (Dectin-2) recognition of alpha-mannans and induction of Th17 cell differentiation is essential for host defence against Candida albicans.
[Homo sapiens] CLEC6A, a C-type lectin receptor, is a pattern recognition receptor critical for immune responses to fungi. CLEC6A is coupled to SYK kinase and signals via CARD9 to activate NFKB, which in turns induces both innate and adaptive immunity.
[Homo sapiens] CLEC6A is critical for the development of house dust mite (Dermatophagoides farinae) elicited eosinophilic and neutrophilic pulmonary inflammation. CLEC6A was also found to be crucial for the Th2 cytokine induction in the lungs and re-stimulated lymph nodes.
[Homo sapiens] CLEC6A is expressed mainly in DCs and macrophages. CLEC6A recognizes alpha-mannans with its carbohydrate recognition domain and transduces signals through association with the ITAM-containing Fc receptor gamma chain, which recruits SYK and initiates the CARD9/NFkB signalling cascade.
[Homo sapiens] CLEC4D and CLEC6A form a heterodimer complex which confers innate cells high ability to sense C. albicans infection by facilitating the activation of NFκB dependent inflammatory responses.
[Homo sapiens] Plasmacytoid dendritic cells (pDCs) directly recognize Aspergillus fumigatus hyphae via CLEC6A; this interaction results in antifungal activity and the formation of pDC extracellular traps.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000205846:
Like dectin-1 (CLEC7A; MIM 606264), CLEC6A, or dectin-2, is a type II membrane receptor with an extracellular C-type lectin-like domain fold. However, unlike dectin-1, dectin-2 lacks an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain (Kanazawa et al., 2004 [PubMed 15175046]).[supplied by OMIM, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:123229843-123247021
Strand Forward strand
Band F2
Transcripts
ENSMUST00000024118 ENSMUSP00000024118
ENSMUST00000112554 ENSMUSP00000108173
ENSMUST00000117130 ENSMUSP00000113733
ENSMUST00000151714 ENSMUSP00000120043
ENSMUST00000144840
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 1 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0030246 carbohydrate binding
Biological Process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087 innate immune response (InnateDB)
GO:0050715 positive regulation of cytokine secretion
GO:0050832 defense response to fungus
Cellular Component
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt Q9JKF4
TrEMBL D6RJL3 Q3U3M9 Q3V2N1
UniProt Splice Variant
Entrez Gene 56620
UniGene Mm.271782
RefSeq NM_001190320 NM_001190321 NM_020001
OMIM
CCDS CCDS20512 CCDS51895 CCDS51896
HPRD
IMGT
MGI ID MGI:1861231
MGI Symbol Clec4n
EMBL AC164111 AF240357 AF240358 AF240359 AK131697 AK154673 BC023008 CH466523
GenPept AAF67177 AAF67178 AAF67179 AAH23008 BAE20766 BAE32756 EDK99710
RNA Seq Atlas 56620