InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Clec4n

Summary

InnateDB Protein

IDBP-255770.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Clec4n

Protein Name

C-type lectin domain family 4, member n

Synonyms

Clec6a; Clecsf10; Nkcl;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000108173

InnateDB Gene

IDBG-186283 (Clec4n)

Protein Structure

UniProt Annotation

Function

Binds high-mannose carbohydrates in a Ca(2+)-dependent manner. Functional receptor for alpha-mannans on C.albicans hypheas. Plays an important role in the host defense against C.albicans infection by inducing TH17 cell differentiation. Recognizes also, in a mannose-dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production. Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptive immune responses. Transduces signals through an Fc receptor gamma chain /FCER1G and Syk-CARD9- NF-kappa-B-dependent pathway. {ECO:0000269PubMed:17050534, ECO:0000269PubMed:19124755, ECO:0000269PubMed:19703985, ECO:0000269PubMed:20493731, ECO:0000269PubMed:21059925}.

Subcellular Localization

Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}. Note=Ligand binding leads to internalization.

Disease Associations

Tissue Specificity

Expressed by the XS52 DC (dendritic cell) line (at protein level). Expressed constitutively by the epidermis, and skin resident DC appear to be the major source of this expression. Expressed in the spleen and thymus. Expression was undetectable in non-DC lines, including macrophage lines (J774 and Raw), T-cell lines (7-17, HDK-1, and D10), B-cell hybridoma (5C5), a keratinocyte line (Pam 212), and a fibroblast line (NS01). {ECO:0000269PubMed:10766825}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	1 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0030246	carbohydrate binding

Biological Process

GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087	innate immune response (InnateDB)
GO:0050715	positive regulation of cytokine secretion
GO:0050832	defense response to fungus