Mus musculus Gene: Tsn
Summary
InnateDB Gene IDBG-186779.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tsn
Gene Name translin
Synonyms 2610034C24Rik; AU040286; C3PO; TB-RBP;
Species Mus musculus
Ensembl Gene ENSMUSG00000026374
Encoded Proteins
translin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000211460:
This gene encodes a DNA-binding protein which specifically recognizes conserved target sequences at the breakpoint junction of chromosomal translocations. Translin polypeptides form a multimeric structure that is responsible for its DNA-binding activity. Recombination-associated motifs and translin-binding sites are present at recombination hotspots and may serve as indicators of breakpoints in genes which are fused by translocations. These binding activities may play a crucial role in chromosomal translocation in lymphoid neoplasms. This protein encoded by this gene, when complexed with translin-associated protein X, also forms a Mg ion-dependent endoribonuclease that promotes RNA-induced silencing complex (RISC) activation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:118294778-118311739
Strand Reverse strand
Band E2.3
Transcripts
ENSMUST00000027623 ENSMUSP00000027623
ENSMUST00000186608
ENSMUST00000188512
ENSMUST00000189768
ENSMUST00000188882
ENSMUST00000186163
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 22 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003697 single-stranded DNA binding
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0004519 endonuclease activity
GO:0005515 protein binding
GO:0032403 protein complex binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0090305 nucleic acid phosphodiester bond hydrolysis
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Gene Expression pathway
Regulatory RNA pathways pathway
Small interfering RNA (siRNA) biogenesis pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Small interfering RNA (siRNA) biogenesis pathway
Gene Expression pathway
Regulatory RNA pathways pathway
Gene Expression pathway
Small interfering RNA (siRNA) biogenesis pathway
Regulatory RNA pathways pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_011650
OMIM
CCDS CCDS35690
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas