InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Tsn

Summary

InnateDB Gene

IDBG-186779.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tsn

Gene Name

translin

Synonyms

2610034C24Rik; AU040286; C3PO; TB-RBP

Species

Mus musculus

Ensembl Gene

ENSMUSG00000026374

Encoded Proteins

IDBP-186781

translin

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000211460:
This gene encodes a DNA-binding protein which specifically recognizes conserved target sequences at the breakpoint junction of chromosomal translocations. Translin polypeptides form a multimeric structure that is responsible for its DNA-binding activity. Recombination-associated motifs and translin-binding sites are present at recombination hotspots and may serve as indicators of breakpoints in genes which are fused by translocations. These binding activities may play a crucial role in chromosomal translocation in lymphoid neoplasms. This protein encoded by this gene, when complexed with translin-associated protein X, also forms a Mg ion-dependent endoribonuclease that promotes RNA-induced silencing complex (RISC) activation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:118294778-118311739

Strand

Reverse strand

Band

E2.3

Transcripts

ENSMUST00000027623	ENSMUSP00000027623
ENSMUST00000186608
ENSMUST00000188512
ENSMUST00000189768
ENSMUST00000188882
ENSMUST00000186163

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	22 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003697	single-stranded DNA binding
GO:0003723	RNA binding
GO:0003729	mRNA binding
GO:0004519	endonuclease activity
GO:0005515	protein binding
GO:0032403	protein complex binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0090305

nucleic acid phosphodiester bond hydrolysis

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000211460

View Gene Order

ENSBTAG00000006059

Not yet available

Pathways

NETPATH

REACTOME

REACT_233572

Gene Expression pathway

REACT_206535

Regulatory RNA pathways pathway

REACT_201975

Small interfering RNA (siRNA) biogenesis pathway

KEGG

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_118560

Small interfering RNA (siRNA) biogenesis pathway

REACT_71

Gene Expression pathway

REACT_12472

Regulatory RNA pathways pathway

REACT_226022

Gene Expression pathway

REACT_222963

Small interfering RNA (siRNA) biogenesis pathway

REACT_210892

Regulatory RNA pathways pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

NM_011650

OMIM

CCDS

CCDS35690

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas