Version 5.4
Mus musculus Gene: Cradd
Summary
InnateDB Gene IDBG-187068.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cradd
Gene Name CASP2 and RIPK1 domain containing adaptor with death domain
Synonyms RAIDD
Species Mus musculus
Ensembl Gene ENSMUSG00000045867
Encoded Proteins
IDBP-187070
CASP2 and RIPK1 domain containing adaptor with death domain
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000169372:
The protein encoded by this gene is a death domain (CARD/DD)-containing protein and has been shown to induce cell apoptosis. Through its CARD domain, this protein interacts with, and thus recruits, caspase 2/ICH1 to the cell death signal transduction complex that includes tumor necrosis factor receptor 1 (TNFR1A), RIPK1/RIP kinase, and numbers of other CARD domain-containing proteins. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:95174746-95324097
Strand Reverse strand
Band C2
Transcripts
ENSMUST00000053594 ENSMUSP00000050295
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
Predicted by orthology
Total 19 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0002020 protease binding
GO:0005515 protein binding
GO:0030674 protein binding, bridging
GO:0070513 death domain binding
Biological Process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0007165 signal transduction
GO:0042981 regulation of apoptotic process
GO:0071260 cellular response to mechanical stimulus
GO:2001235 positive regulation of apoptotic signaling pathway
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000169372
View Gene Order
ENSBTAG00000005107
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_9
TNFalpha pathway
REACTOME
KEGG
INOH
PID NCI
ceramide_pathway
Ceramide signaling pathway
caspase_pathway
Caspase Cascade in Apoptosis
hivnefpathway
HIV-1 Nef: Negative effector of Fas and TNF-alpha
Cross-References
SwissProt O88843
TrEMBL Q549T4 Q9QWR7
UniProt Splice Variant
Entrez Gene 12905
UniGene
RefSeq NM_009950 XM_006513178 XM_006513179 XM_006513180 XM_006513181 XM_006513182 XM_006513185
OMIM
CCDS CCDS24135
HPRD
IMGT
MGI ID MGI:1336168
MGI Symbol Cradd
EMBL AE016773 AF017992 AJ224738 AJ224739 AJ224740 AK136561 AK163112 BC005608 CH466539
GenPept AAC35882 AAH05608 AAN84619 BAE23045 BAE37198 CAA12107 CAA12108 CAA12109 EDL21592 EDL21593 EDL21595 EDL21596
RNA Seq Atlas 12905

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca