InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CRADD

Summary

InnateDB Gene

IDBG-51368.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CRADD

Gene Name

CASP2 and RIPK1 domain containing adaptor with death domain

Synonyms

MRT34; RAIDD

Species

Homo sapiens

Ensembl Gene

ENSG00000169372

Encoded Proteins

IDBP-51370

CASP2 and RIPK1 domain containing adaptor with death domain

IDBP-591564

CASP2 and RIPK1 domain containing adaptor with death domain

IDBP-599770

CASP2 and RIPK1 domain containing adaptor with death domain

IDBP-601448

CASP2 and RIPK1 domain containing adaptor with death domain

IDBP-588264

CASP2 and RIPK1 domain containing adaptor with death domain

IDBP-586447

CASP2 and RIPK1 domain containing adaptor with death domain

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a death domain (CARD/DD)-containing protein and has been shown to induce cell apoptosis. Through its CARD domain, this protein interacts with, and thus recruits, caspase 2/ICH1 to the cell death signal transduction complex that includes tumor necrosis factor receptor 1 (TNFR1A), RIPK1/RIP kinase, and numbers of other CARD domain-containing proteins. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:93677375-93894840

Strand

Forward strand

Band

q22

Transcripts

ENST00000332896	ENSP00000327647
ENST00000552983	ENSP00000449570
ENST00000549615
ENST00000552033	ENSP00000449664
ENST00000548483	ENSP00000448685
ENST00000551065	ENSP00000448425
ENST00000542893	ENSP00000439068
ENST00000547383
ENST00000550030
ENST00000548330
ENST00000609189

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.

Experimentally validated
Total	26 [view]
Protein-Protein	20 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0005515	protein binding
GO:0030674	protein binding, bridging
GO:0070513	death domain binding

Biological Process

GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0007165	signal transduction
GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors
GO:0042981	regulation of apoptotic process
GO:0071260	cellular response to mechanical stimulus
GO:2001235	positive regulation of apoptotic signaling pathway

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000045867

View Gene Order

ENSBTAG00000005107

Not yet available

Pathways

NETPATH

NetPath_9

TNFalpha pathway

REACTOME

KEGG

INOH

PID NCI

ceramide_pathway

Ceramide signaling pathway

caspase_pathway

Caspase Cascade in Apoptosis

hivnefpathway

HIV-1 Nef: Negative effector of Fas and TNF-alpha

Cross-References

SwissProt

TrEMBL

B7Z2Q5

UniProt Splice Variant

Entrez Gene

8738

UniGene

Hs.38533 Hs.591016 Hs.660031 Hs.719191

RefSeq

NM_003805 XM_005269211

HUGO

HGNC:2340

OMIM

603454

CCDS

CCDS9048

HPRD

04584

IMGT

EMBL

AC012085 AC012464 AC025261 AK294986

GenPept

BAH11941

RNA Seq Atlas

8738