Version 5.4
Mus musculus Gene: Krt4
Summary
InnateDB Gene IDBG-187191.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Krt4
Gene Name keratin 4
Synonyms AW108092; K4; Krt-2.4; Krt2-4
Species Mus musculus
Ensembl Gene ENSMUSG00000059668
Encoded Proteins
IDBP-187193
keratin 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000170477:
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in differentiated layers of the mucosal and esophageal epithelia with family member KRT13. Mutations in these genes have been associated with White Sponge Nevus, characterized by oral, esophageal, and anal leukoplakia. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:101918536-101924735
Strand Reverse strand
Band F2
Transcripts
ENSMUST00000023797 ENSMUSP00000023797
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005198 structural molecule activity
GO:0005515 protein binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0007010 cytoskeleton organization
GO:0009790 embryo development
GO:0030855 epithelial cell differentiation
GO:0050680 negative regulation of epithelial cell proliferation
Cellular Component
GO:0005634 nucleus
GO:0005882 intermediate filament
GO:0009986 cell surface
GO:0045095 keratin filament
GO:0045111 intermediate filament cytoskeleton
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000170477
View Gene Order
ENSBTAG00000012034
Not yet available
Cross-References
SwissProt P07744
TrEMBL
UniProt Splice Variant
Entrez Gene 16682
UniGene Mm.46425
RefSeq NM_008475
OMIM
CCDS CCDS37222
HPRD
IMGT
MGI ID MGI:96701
MGI Symbol Krt4
EMBL BC064008 BC145839 BC145841 X03491
GenPept AAH64008 AAI45840 AAI45842 CAA27207
RNA Seq Atlas 16682

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca